Biodegradable nanomats produced by electrospinning : expanding multifunctionality and potential for tissue engineering
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/20137 |
Resumo: | With increasing interest in nanotechnology, development of nanofibers (n-fibers) by using the technique of electrospinning is gaining new momentum. Among important potential applications of n-fiber-based structures, scaffolds for tissue-engineering represent an advancing front. Nanoscaffolds (n-scaffolds) are closer to natural extracellular matrix (ECM) and its nanoscale fibrous structure. Although the technique of electrospinning is relatively old, various improvements have been made in the last decades to explore the spinning of submicron fibers from biodegradable polymers and to develop also multifunctional drug-releasing and bioactive scaffolds. Various factors can affect the properties of resulting nanostructures that can be classified into three main categories, namely: (1) Substrate related, (2) Apparatus related, and (3) Environment related factors. Developed n-scaffolds were tested for their cytocompatibility using different cell models and were seeded with cells for to develop tissue engineering constructs. Most importantly, studies have looked at the potential of using n-scaffolds for the development of blood vessels. There is a large area ahead for further applications and development of the field. For instance, multifunctional scaffolds that can be used as controlled delivery system do have a potential and have yet to be investigated for engineering of various tissues. So far, in vivo data on n-scaffolds are scarce, but in future reports are expected to emerge. With the convergence of the fields of nanotechnology, drug release and tissue engineering, new solutions could be found for the current limitations of tissue engineering scaffolds, which may enhance their functionality upon in vivo implantation. In this paper electrospinning process, factors affecting it, used polymers, developed n-scaffolds and their characterization are reviewed with focus on application in tissue engineering. |
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Biodegradable nanomats produced by electrospinning : expanding multifunctionality and potential for tissue engineeringDrug releaseElectrospinningMultifunctionalNanofiberNanotechnologyRegenerationscaffoldtissue engineeringScience & TechnologyWith increasing interest in nanotechnology, development of nanofibers (n-fibers) by using the technique of electrospinning is gaining new momentum. Among important potential applications of n-fiber-based structures, scaffolds for tissue-engineering represent an advancing front. Nanoscaffolds (n-scaffolds) are closer to natural extracellular matrix (ECM) and its nanoscale fibrous structure. Although the technique of electrospinning is relatively old, various improvements have been made in the last decades to explore the spinning of submicron fibers from biodegradable polymers and to develop also multifunctional drug-releasing and bioactive scaffolds. Various factors can affect the properties of resulting nanostructures that can be classified into three main categories, namely: (1) Substrate related, (2) Apparatus related, and (3) Environment related factors. Developed n-scaffolds were tested for their cytocompatibility using different cell models and were seeded with cells for to develop tissue engineering constructs. Most importantly, studies have looked at the potential of using n-scaffolds for the development of blood vessels. There is a large area ahead for further applications and development of the field. For instance, multifunctional scaffolds that can be used as controlled delivery system do have a potential and have yet to be investigated for engineering of various tissues. So far, in vivo data on n-scaffolds are scarce, but in future reports are expected to emerge. With the convergence of the fields of nanotechnology, drug release and tissue engineering, new solutions could be found for the current limitations of tissue engineering scaffolds, which may enhance their functionality upon in vivo implantation. In this paper electrospinning process, factors affecting it, used polymers, developed n-scaffolds and their characterization are reviewed with focus on application in tissue engineering.American Scientific PublishersUniversidade do MinhoAshammakhi, N.Ndreu, A.Piras, A. M.Nikkola, L.Sindelar, T.Ylikauppila, H.Harlin, A.Gomes, Manuela E.Neves, N. M.Chiellini, E.Chiellini, F.Hasirci, VasifRedl, HeinzReis, R. L.20072007-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/20137eng1533-488010.1166/jnn.2007.48517450849info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:20:08Zoai:repositorium.sdum.uminho.pt:1822/20137Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:13:12.851635Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Biodegradable nanomats produced by electrospinning : expanding multifunctionality and potential for tissue engineering |
title |
Biodegradable nanomats produced by electrospinning : expanding multifunctionality and potential for tissue engineering |
spellingShingle |
Biodegradable nanomats produced by electrospinning : expanding multifunctionality and potential for tissue engineering Ashammakhi, N. Drug release Electrospinning Multifunctional Nanofiber Nanotechnology Regeneration scaffold tissue engineering Science & Technology |
title_short |
Biodegradable nanomats produced by electrospinning : expanding multifunctionality and potential for tissue engineering |
title_full |
Biodegradable nanomats produced by electrospinning : expanding multifunctionality and potential for tissue engineering |
title_fullStr |
Biodegradable nanomats produced by electrospinning : expanding multifunctionality and potential for tissue engineering |
title_full_unstemmed |
Biodegradable nanomats produced by electrospinning : expanding multifunctionality and potential for tissue engineering |
title_sort |
Biodegradable nanomats produced by electrospinning : expanding multifunctionality and potential for tissue engineering |
author |
Ashammakhi, N. |
author_facet |
Ashammakhi, N. Ndreu, A. Piras, A. M. Nikkola, L. Sindelar, T. Ylikauppila, H. Harlin, A. Gomes, Manuela E. Neves, N. M. Chiellini, E. Chiellini, F. Hasirci, Vasif Redl, Heinz Reis, R. L. |
author_role |
author |
author2 |
Ndreu, A. Piras, A. M. Nikkola, L. Sindelar, T. Ylikauppila, H. Harlin, A. Gomes, Manuela E. Neves, N. M. Chiellini, E. Chiellini, F. Hasirci, Vasif Redl, Heinz Reis, R. L. |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Ashammakhi, N. Ndreu, A. Piras, A. M. Nikkola, L. Sindelar, T. Ylikauppila, H. Harlin, A. Gomes, Manuela E. Neves, N. M. Chiellini, E. Chiellini, F. Hasirci, Vasif Redl, Heinz Reis, R. L. |
dc.subject.por.fl_str_mv |
Drug release Electrospinning Multifunctional Nanofiber Nanotechnology Regeneration scaffold tissue engineering Science & Technology |
topic |
Drug release Electrospinning Multifunctional Nanofiber Nanotechnology Regeneration scaffold tissue engineering Science & Technology |
description |
With increasing interest in nanotechnology, development of nanofibers (n-fibers) by using the technique of electrospinning is gaining new momentum. Among important potential applications of n-fiber-based structures, scaffolds for tissue-engineering represent an advancing front. Nanoscaffolds (n-scaffolds) are closer to natural extracellular matrix (ECM) and its nanoscale fibrous structure. Although the technique of electrospinning is relatively old, various improvements have been made in the last decades to explore the spinning of submicron fibers from biodegradable polymers and to develop also multifunctional drug-releasing and bioactive scaffolds. Various factors can affect the properties of resulting nanostructures that can be classified into three main categories, namely: (1) Substrate related, (2) Apparatus related, and (3) Environment related factors. Developed n-scaffolds were tested for their cytocompatibility using different cell models and were seeded with cells for to develop tissue engineering constructs. Most importantly, studies have looked at the potential of using n-scaffolds for the development of blood vessels. There is a large area ahead for further applications and development of the field. For instance, multifunctional scaffolds that can be used as controlled delivery system do have a potential and have yet to be investigated for engineering of various tissues. So far, in vivo data on n-scaffolds are scarce, but in future reports are expected to emerge. With the convergence of the fields of nanotechnology, drug release and tissue engineering, new solutions could be found for the current limitations of tissue engineering scaffolds, which may enhance their functionality upon in vivo implantation. In this paper electrospinning process, factors affecting it, used polymers, developed n-scaffolds and their characterization are reviewed with focus on application in tissue engineering. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007 2007-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/20137 |
url |
http://hdl.handle.net/1822/20137 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1533-4880 10.1166/jnn.2007.485 17450849 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
American Scientific Publishers |
publisher.none.fl_str_mv |
American Scientific Publishers |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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