Optical coherence tomography angiography metrics Monitor severity progression of diabetic retinopathy—3-year longitudinal study
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.22/18162 |
Resumo: | To examine retinal vessel closure metrics and neurodegenerative changes occurring in the initial stages of nonproliferative diabetic retinopathy (NPDR) and severity progression in a three-year period. Three-year prospective longitudinal observational cohort of individuals with type 2 diabetes (T2D), one eye per person, using spectral domain-optical coherence tomography (SD-OCT) and OCT-Angiography (OCTA). Eyes were examined four times with one-year intervals. OCTA vessel density maps of the retina were used to quantify vessel closure. Thickness of the ganglion cell + inner plexiform layer (GCL + IPL) was examined to identify retinal neurodegenerative changes. Diabetic retinopathy ETDRS classification was performed using the seven-field ETDRS protocol. A total of 78 eyes/patients, aged 52 to 80 years, with T2D and ETDRS grades from 10 to 47 were followed for 3 years with annual examinations. A progressive increase in retinal vessel closure was observed. Vessel density (VD) showed higher decreases with retinopathy worsening demonstrated by step-changes in ETDRS severity scale (p < 0.001). No clear correlation was observed between neurodegenerative changes and retinopathy progression. Conclusions: Retinal vessel closure in NPDR correlates with DR severity progression. Our findings provide supporting evidence that OCTA metrics of vessel closure may be used as a surrogate for DR severity progression. |
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Optical coherence tomography angiography metrics Monitor severity progression of diabetic retinopathy—3-year longitudinal studyOCTADiabetesRetinopathySeverityIschemiaTo examine retinal vessel closure metrics and neurodegenerative changes occurring in the initial stages of nonproliferative diabetic retinopathy (NPDR) and severity progression in a three-year period. Three-year prospective longitudinal observational cohort of individuals with type 2 diabetes (T2D), one eye per person, using spectral domain-optical coherence tomography (SD-OCT) and OCT-Angiography (OCTA). Eyes were examined four times with one-year intervals. OCTA vessel density maps of the retina were used to quantify vessel closure. Thickness of the ganglion cell + inner plexiform layer (GCL + IPL) was examined to identify retinal neurodegenerative changes. Diabetic retinopathy ETDRS classification was performed using the seven-field ETDRS protocol. A total of 78 eyes/patients, aged 52 to 80 years, with T2D and ETDRS grades from 10 to 47 were followed for 3 years with annual examinations. A progressive increase in retinal vessel closure was observed. Vessel density (VD) showed higher decreases with retinopathy worsening demonstrated by step-changes in ETDRS severity scale (p < 0.001). No clear correlation was observed between neurodegenerative changes and retinopathy progression. Conclusions: Retinal vessel closure in NPDR correlates with DR severity progression. Our findings provide supporting evidence that OCTA metrics of vessel closure may be used as a surrogate for DR severity progression.MDPIRepositório Científico do Instituto Politécnico do PortoMarques, Inês P.Kubach, SophieSantos, TorcatoMendes, LuísMadeira, Maria H.Sisternes, Luis deTavares, DianaSantos, Ana RitaLewis, WarrenLobo, ConceiçãoDurbin, Mary K.Cunha-Vaz, José2021-07-23T10:23:46Z2021-05-242021-05-24T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/18162engMarques, I. P., Kubach, S., Santos, T., Mendes, L., Madeira, M. H., de Sisternes, L., Tavares, D., Santos, A. R., Lewis, W., Lobo, C., Durbin, M. K., & Cunha-Vaz, J. (2021). Optical Coherence Tomography Angiography Metrics Monitor Severity Progression of Diabetic Retinopathy—3-Year Longitudinal Study. Journal of Clinical Medicine, 10(11). https://doi.org/10.3390/jcm101122962077-038310.3390/jcm10112296info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T13:09:28Zoai:recipp.ipp.pt:10400.22/18162Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:37:46.027368Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Optical coherence tomography angiography metrics Monitor severity progression of diabetic retinopathy—3-year longitudinal study |
title |
Optical coherence tomography angiography metrics Monitor severity progression of diabetic retinopathy—3-year longitudinal study |
spellingShingle |
Optical coherence tomography angiography metrics Monitor severity progression of diabetic retinopathy—3-year longitudinal study Marques, Inês P. OCTA Diabetes Retinopathy Severity Ischemia |
title_short |
Optical coherence tomography angiography metrics Monitor severity progression of diabetic retinopathy—3-year longitudinal study |
title_full |
Optical coherence tomography angiography metrics Monitor severity progression of diabetic retinopathy—3-year longitudinal study |
title_fullStr |
Optical coherence tomography angiography metrics Monitor severity progression of diabetic retinopathy—3-year longitudinal study |
title_full_unstemmed |
Optical coherence tomography angiography metrics Monitor severity progression of diabetic retinopathy—3-year longitudinal study |
title_sort |
Optical coherence tomography angiography metrics Monitor severity progression of diabetic retinopathy—3-year longitudinal study |
author |
Marques, Inês P. |
author_facet |
Marques, Inês P. Kubach, Sophie Santos, Torcato Mendes, Luís Madeira, Maria H. Sisternes, Luis de Tavares, Diana Santos, Ana Rita Lewis, Warren Lobo, Conceição Durbin, Mary K. Cunha-Vaz, José |
author_role |
author |
author2 |
Kubach, Sophie Santos, Torcato Mendes, Luís Madeira, Maria H. Sisternes, Luis de Tavares, Diana Santos, Ana Rita Lewis, Warren Lobo, Conceição Durbin, Mary K. Cunha-Vaz, José |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Marques, Inês P. Kubach, Sophie Santos, Torcato Mendes, Luís Madeira, Maria H. Sisternes, Luis de Tavares, Diana Santos, Ana Rita Lewis, Warren Lobo, Conceição Durbin, Mary K. Cunha-Vaz, José |
dc.subject.por.fl_str_mv |
OCTA Diabetes Retinopathy Severity Ischemia |
topic |
OCTA Diabetes Retinopathy Severity Ischemia |
description |
To examine retinal vessel closure metrics and neurodegenerative changes occurring in the initial stages of nonproliferative diabetic retinopathy (NPDR) and severity progression in a three-year period. Three-year prospective longitudinal observational cohort of individuals with type 2 diabetes (T2D), one eye per person, using spectral domain-optical coherence tomography (SD-OCT) and OCT-Angiography (OCTA). Eyes were examined four times with one-year intervals. OCTA vessel density maps of the retina were used to quantify vessel closure. Thickness of the ganglion cell + inner plexiform layer (GCL + IPL) was examined to identify retinal neurodegenerative changes. Diabetic retinopathy ETDRS classification was performed using the seven-field ETDRS protocol. A total of 78 eyes/patients, aged 52 to 80 years, with T2D and ETDRS grades from 10 to 47 were followed for 3 years with annual examinations. A progressive increase in retinal vessel closure was observed. Vessel density (VD) showed higher decreases with retinopathy worsening demonstrated by step-changes in ETDRS severity scale (p < 0.001). No clear correlation was observed between neurodegenerative changes and retinopathy progression. Conclusions: Retinal vessel closure in NPDR correlates with DR severity progression. Our findings provide supporting evidence that OCTA metrics of vessel closure may be used as a surrogate for DR severity progression. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-23T10:23:46Z 2021-05-24 2021-05-24T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/18162 |
url |
http://hdl.handle.net/10400.22/18162 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Marques, I. P., Kubach, S., Santos, T., Mendes, L., Madeira, M. H., de Sisternes, L., Tavares, D., Santos, A. R., Lewis, W., Lobo, C., Durbin, M. K., & Cunha-Vaz, J. (2021). Optical Coherence Tomography Angiography Metrics Monitor Severity Progression of Diabetic Retinopathy—3-Year Longitudinal Study. Journal of Clinical Medicine, 10(11). https://doi.org/10.3390/jcm10112296 2077-0383 10.3390/jcm10112296 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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