Hepatocellular Carcinoma: An Unusual Presentation of this Rare Clinical Entity in Children
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/4245 |
Resumo: | Malignant hepatic tumors are rare in children and hepatocellular carcinomas only represent 20% of cases. A previously healthy 10 year-old male was admitted for sudden abdominal pain. Ultrasound imaging showed an ileo-ileal intussusception with spontaneous resolution, but in the face of worsening pain, fever, and a palpable epigastric mass, abdominal magnetic resonance imaging was performed, showing a liver lesion. Laboratory tests presented elevated liver enzymes and C-reactive protein, so a liver abscess was considered and treated with metronidazole plus ceftriaxone. All of the microbiology tests as well as tumoral markers were negative. Despite clinical and laboratory improvement, the lesion persisted in the imaging. A liver biopsy confirmed a hepatocellular carcinoma, and the patient was submitted to surgical resection and chemotherapy. Contrarily to adults in whom most cases are secondary to chronic liver disease, children may not have risk factors for the disease, which makes it harder to make a prompt diagnosis. |
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Hepatocellular Carcinoma: An Unusual Presentation of this Rare Clinical Entity in ChildrenAbdominal Pain/etiologyCarcinoma, Hepatocellular/diagnosisCarcinoma, Hepatocellular/ pathologyChildHDE CIR PEDMalignant hepatic tumors are rare in children and hepatocellular carcinomas only represent 20% of cases. A previously healthy 10 year-old male was admitted for sudden abdominal pain. Ultrasound imaging showed an ileo-ileal intussusception with spontaneous resolution, but in the face of worsening pain, fever, and a palpable epigastric mass, abdominal magnetic resonance imaging was performed, showing a liver lesion. Laboratory tests presented elevated liver enzymes and C-reactive protein, so a liver abscess was considered and treated with metronidazole plus ceftriaxone. All of the microbiology tests as well as tumoral markers were negative. Despite clinical and laboratory improvement, the lesion persisted in the imaging. A liver biopsy confirmed a hepatocellular carcinoma, and the patient was submitted to surgical resection and chemotherapy. Contrarily to adults in whom most cases are secondary to chronic liver disease, children may not have risk factors for the disease, which makes it harder to make a prompt diagnosis.Sociedade Portuguesa de PediatriaRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEMartins, MCardosa, MFCalhau, PCaldas, GAlves, R2022-09-14T12:11:10Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/4245engPort J Pediatr 2021;52:143-8doi.org/10.25754/pjp.2021.20462info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:46:02ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Hepatocellular Carcinoma: An Unusual Presentation of this Rare Clinical Entity in Children |
title |
Hepatocellular Carcinoma: An Unusual Presentation of this Rare Clinical Entity in Children |
spellingShingle |
Hepatocellular Carcinoma: An Unusual Presentation of this Rare Clinical Entity in Children Martins, M Abdominal Pain/etiology Carcinoma, Hepatocellular/diagnosis Carcinoma, Hepatocellular/ pathology Child HDE CIR PED |
title_short |
Hepatocellular Carcinoma: An Unusual Presentation of this Rare Clinical Entity in Children |
title_full |
Hepatocellular Carcinoma: An Unusual Presentation of this Rare Clinical Entity in Children |
title_fullStr |
Hepatocellular Carcinoma: An Unusual Presentation of this Rare Clinical Entity in Children |
title_full_unstemmed |
Hepatocellular Carcinoma: An Unusual Presentation of this Rare Clinical Entity in Children |
title_sort |
Hepatocellular Carcinoma: An Unusual Presentation of this Rare Clinical Entity in Children |
author |
Martins, M |
author_facet |
Martins, M Cardosa, MF Calhau, P Caldas, G Alves, R |
author_role |
author |
author2 |
Cardosa, MF Calhau, P Caldas, G Alves, R |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Martins, M Cardosa, MF Calhau, P Caldas, G Alves, R |
dc.subject.por.fl_str_mv |
Abdominal Pain/etiology Carcinoma, Hepatocellular/diagnosis Carcinoma, Hepatocellular/ pathology Child HDE CIR PED |
topic |
Abdominal Pain/etiology Carcinoma, Hepatocellular/diagnosis Carcinoma, Hepatocellular/ pathology Child HDE CIR PED |
description |
Malignant hepatic tumors are rare in children and hepatocellular carcinomas only represent 20% of cases. A previously healthy 10 year-old male was admitted for sudden abdominal pain. Ultrasound imaging showed an ileo-ileal intussusception with spontaneous resolution, but in the face of worsening pain, fever, and a palpable epigastric mass, abdominal magnetic resonance imaging was performed, showing a liver lesion. Laboratory tests presented elevated liver enzymes and C-reactive protein, so a liver abscess was considered and treated with metronidazole plus ceftriaxone. All of the microbiology tests as well as tumoral markers were negative. Despite clinical and laboratory improvement, the lesion persisted in the imaging. A liver biopsy confirmed a hepatocellular carcinoma, and the patient was submitted to surgical resection and chemotherapy. Contrarily to adults in whom most cases are secondary to chronic liver disease, children may not have risk factors for the disease, which makes it harder to make a prompt diagnosis. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z 2022-09-14T12:11:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/4245 |
url |
http://hdl.handle.net/10400.17/4245 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Port J Pediatr 2021;52:143-8 doi.org/10.25754/pjp.2021.20462 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Pediatria |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Pediatria |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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1777302279304511488 |