Impact of Subsyndromal Delirium Occurrence and Its Trajectory during ICU Stay
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/146145 |
Resumo: | Funding Information: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Publisher Copyright: © 2022 by the authors. |
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Impact of Subsyndromal Delirium Occurrence and Its Trajectory during ICU Staycognitive dysfunctioncritically illdeliriumICUsubsyndromal deliriumMedicine(all)Funding Information: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Publisher Copyright: © 2022 by the authors.Despite recent advances in the field, the association between subsyndromal delirium (SSD) in the ICU and poor outcomes is not entirely clear. We performed a retrospective multicentric observational study analyzing mental status during the first 72 h of ICU stay. Of the 681 patients included, SSD occurred in 22.7%. Considering the worst cognitive assessment during the first 72 h, 233 (34%) patients had normal mental status, 124 (18%) patients had SSD and 324 (48%) patients had delirium or coma. SSD was not independently associated with an increased risk of death when compared with normal mental status (OR 95%IC 1.0 vs. 1.35 [0.73–1.49], p = 0.340), but was associated with a longer ICU LOS (7.0 (4–12) vs. 4 (3–8) days, p < 0.001). SSD patients who deteriorated to delirium or coma (21%) had a longer ICU LOS in comparison with those who improved or maintained mental status (8 (5–11) vs. 6 (4–8) days, p = 0.025), but did not have an increase in mortality. The main factors associated with the progression from SSD to delirium or coma were the use of mechanical ventilation, the use of intravenous benzodiazepines and a baseline APACHE II score > 23 points. Our findings support the association of SSD with increased ICU LOS, but not with ICU mortality. Monitoring the trajectory of SSD early at ICU admission can help to identify patients with increased risk of conversion from SSD to delirium or coma.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNSerafim, Rodrigo B.Dal-Pizzol, FelipeSouza-Dantas, VicenteSoares, MarcioBozza, Fernando A.Povoa, PedroLuiz, Ronir RaggioLapa e Silva, José R.Salluh, Jorge I.F.2022-12-12T22:14:31Z2022-112022-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/146145eng2077-0383PURE: 48188375https://doi.org/10.3390/jcm11226797info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:27:11Zoai:run.unl.pt:10362/146145Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:52:30.460691Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Impact of Subsyndromal Delirium Occurrence and Its Trajectory during ICU Stay |
| title |
Impact of Subsyndromal Delirium Occurrence and Its Trajectory during ICU Stay |
| spellingShingle |
Impact of Subsyndromal Delirium Occurrence and Its Trajectory during ICU Stay Serafim, Rodrigo B. cognitive dysfunction critically ill delirium ICU subsyndromal delirium Medicine(all) |
| title_short |
Impact of Subsyndromal Delirium Occurrence and Its Trajectory during ICU Stay |
| title_full |
Impact of Subsyndromal Delirium Occurrence and Its Trajectory during ICU Stay |
| title_fullStr |
Impact of Subsyndromal Delirium Occurrence and Its Trajectory during ICU Stay |
| title_full_unstemmed |
Impact of Subsyndromal Delirium Occurrence and Its Trajectory during ICU Stay |
| title_sort |
Impact of Subsyndromal Delirium Occurrence and Its Trajectory during ICU Stay |
| author |
Serafim, Rodrigo B. |
| author_facet |
Serafim, Rodrigo B. Dal-Pizzol, Felipe Souza-Dantas, Vicente Soares, Marcio Bozza, Fernando A. Povoa, Pedro Luiz, Ronir Raggio Lapa e Silva, José R. Salluh, Jorge I.F. |
| author_role |
author |
| author2 |
Dal-Pizzol, Felipe Souza-Dantas, Vicente Soares, Marcio Bozza, Fernando A. Povoa, Pedro Luiz, Ronir Raggio Lapa e Silva, José R. Salluh, Jorge I.F. |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centro de Estudos de Doenças Crónicas (CEDOC) RUN |
| dc.contributor.author.fl_str_mv |
Serafim, Rodrigo B. Dal-Pizzol, Felipe Souza-Dantas, Vicente Soares, Marcio Bozza, Fernando A. Povoa, Pedro Luiz, Ronir Raggio Lapa e Silva, José R. Salluh, Jorge I.F. |
| dc.subject.por.fl_str_mv |
cognitive dysfunction critically ill delirium ICU subsyndromal delirium Medicine(all) |
| topic |
cognitive dysfunction critically ill delirium ICU subsyndromal delirium Medicine(all) |
| description |
Funding Information: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Publisher Copyright: © 2022 by the authors. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-12-12T22:14:31Z 2022-11 2022-11-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/146145 |
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http://hdl.handle.net/10362/146145 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2077-0383 PURE: 48188375 https://doi.org/10.3390/jcm11226797 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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