Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/24239 |
Resumo: | The combination of biodegradable fibers at nanoscale with plant-based extracts is attracting increasing attention to produce wound dressing systems. In this work, nanofibers based on chitosan (CS), poly(ethylene oxide) (PEO), cellulose nanocrystals (CNC) and acacia plant-based extract were developed by electrospinning. Firstly, the polymeric formulations and electrospinning parameters were optimized, resulting in nanofibers with average diameters of 80 nm. CNC were successfully introduced into the optimized CS/PEO blend and the membranes were characterized by FESEM, ATR-FTIR, TGA, XRD, WVTR and WCA. The CNC incorporation improved the nanofibers' physical integrity, morphology, diameters, water vapor transmission rate and thermal properties. After acacia introduction into the best CS/PEO/CNC system, the antibacterial effect was relatively maintained while the antifungal activity was enhanced for some fungi, demonstrating its great effect against a wide range of microorganisms, which is crucial to prevent or treat infections. All the developed systems exhibited absence of cytotoxicity in non-tumor cells, suggesting their biocompatibility. Finally, a continuous release of the acacia extract was observed for 24 h, showing its prolonged action, which contributes to the healing process while reduces the frequency of dressing's replacement. Overall, the developed nanofibers are very promising to act as localized drug delivery systems for wound care applications. |
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Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applicationsAcacia natural extractCellulose nanocrystals (CNC)ChitosanDrug delivery systemsElectrospun nanofibersThe combination of biodegradable fibers at nanoscale with plant-based extracts is attracting increasing attention to produce wound dressing systems. In this work, nanofibers based on chitosan (CS), poly(ethylene oxide) (PEO), cellulose nanocrystals (CNC) and acacia plant-based extract were developed by electrospinning. Firstly, the polymeric formulations and electrospinning parameters were optimized, resulting in nanofibers with average diameters of 80 nm. CNC were successfully introduced into the optimized CS/PEO blend and the membranes were characterized by FESEM, ATR-FTIR, TGA, XRD, WVTR and WCA. The CNC incorporation improved the nanofibers' physical integrity, morphology, diameters, water vapor transmission rate and thermal properties. After acacia introduction into the best CS/PEO/CNC system, the antibacterial effect was relatively maintained while the antifungal activity was enhanced for some fungi, demonstrating its great effect against a wide range of microorganisms, which is crucial to prevent or treat infections. All the developed systems exhibited absence of cytotoxicity in non-tumor cells, suggesting their biocompatibility. Finally, a continuous release of the acacia extract was observed for 24 h, showing its prolonged action, which contributes to the healing process while reduces the frequency of dressing's replacement. Overall, the developed nanofibers are very promising to act as localized drug delivery systems for wound care applications.The authors are thankful to TSSiPRO project, operation code NORTE01-0145-FEDER-000015. The authors are also grateful to FCT, Portugal for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020) and to 2C2T (UID/CTM/00264/2019). D. P. Ferreira thank the national funding by FCT through the individual scientific employment program-contract (CEECIND/02803/2017), S. M. Costa thank the FCT PhD Scholarship (SFRH/BD/147517/2019), and L. Barros and R. Calhelha thank the institutional scientific employment program-contract. This work has been supported by the Ministry of Education, Science and Technological Development of Republic of Serbia (451-03-68/2020-14/200007).Biblioteca Digital do IPBRibeiro, Ana S.Costa, Sofia M.Ferreira, Diana P.Calhelha, Ricardo C.Barros, LillianStojković, DejanSoković, MarinaFerreira, Isabel C.F.R.Fangueiro, Raul2018-01-19T10:00:00Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/24239engRibeiro, Ana S.; Costa, Sofia M.; Ferreira, Diana P.; Calhelha, Ricardo C.; Barros, Lillian; Stojković, Dejan; Soković, Marina; Ferreira, Isabel C.F.R.; Fangueiro, Raul (2021). Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications. Reactive and Functional Polymers. ISSN 1381-5148. 159, p. 1-101381-514810.1016/j.reactfunctpolym.2020.104808info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:54:10Zoai:bibliotecadigital.ipb.pt:10198/24239Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:15:05.505913Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications |
title |
Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications |
spellingShingle |
Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications Ribeiro, Ana S. Acacia natural extract Cellulose nanocrystals (CNC) Chitosan Drug delivery systems Electrospun nanofibers |
title_short |
Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications |
title_full |
Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications |
title_fullStr |
Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications |
title_full_unstemmed |
Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications |
title_sort |
Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications |
author |
Ribeiro, Ana S. |
author_facet |
Ribeiro, Ana S. Costa, Sofia M. Ferreira, Diana P. Calhelha, Ricardo C. Barros, Lillian Stojković, Dejan Soković, Marina Ferreira, Isabel C.F.R. Fangueiro, Raul |
author_role |
author |
author2 |
Costa, Sofia M. Ferreira, Diana P. Calhelha, Ricardo C. Barros, Lillian Stojković, Dejan Soković, Marina Ferreira, Isabel C.F.R. Fangueiro, Raul |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Ribeiro, Ana S. Costa, Sofia M. Ferreira, Diana P. Calhelha, Ricardo C. Barros, Lillian Stojković, Dejan Soković, Marina Ferreira, Isabel C.F.R. Fangueiro, Raul |
dc.subject.por.fl_str_mv |
Acacia natural extract Cellulose nanocrystals (CNC) Chitosan Drug delivery systems Electrospun nanofibers |
topic |
Acacia natural extract Cellulose nanocrystals (CNC) Chitosan Drug delivery systems Electrospun nanofibers |
description |
The combination of biodegradable fibers at nanoscale with plant-based extracts is attracting increasing attention to produce wound dressing systems. In this work, nanofibers based on chitosan (CS), poly(ethylene oxide) (PEO), cellulose nanocrystals (CNC) and acacia plant-based extract were developed by electrospinning. Firstly, the polymeric formulations and electrospinning parameters were optimized, resulting in nanofibers with average diameters of 80 nm. CNC were successfully introduced into the optimized CS/PEO blend and the membranes were characterized by FESEM, ATR-FTIR, TGA, XRD, WVTR and WCA. The CNC incorporation improved the nanofibers' physical integrity, morphology, diameters, water vapor transmission rate and thermal properties. After acacia introduction into the best CS/PEO/CNC system, the antibacterial effect was relatively maintained while the antifungal activity was enhanced for some fungi, demonstrating its great effect against a wide range of microorganisms, which is crucial to prevent or treat infections. All the developed systems exhibited absence of cytotoxicity in non-tumor cells, suggesting their biocompatibility. Finally, a continuous release of the acacia extract was observed for 24 h, showing its prolonged action, which contributes to the healing process while reduces the frequency of dressing's replacement. Overall, the developed nanofibers are very promising to act as localized drug delivery systems for wound care applications. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-19T10:00:00Z 2021 2021-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/24239 |
url |
http://hdl.handle.net/10198/24239 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ribeiro, Ana S.; Costa, Sofia M.; Ferreira, Diana P.; Calhelha, Ricardo C.; Barros, Lillian; Stojković, Dejan; Soković, Marina; Ferreira, Isabel C.F.R.; Fangueiro, Raul (2021). Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications. Reactive and Functional Polymers. ISSN 1381-5148. 159, p. 1-10 1381-5148 10.1016/j.reactfunctpolym.2020.104808 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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