Major Multiform Erythema with Sertraline

• Main Author: Carvalho, Sandrina
• Publication Date: 2015
• Other Authors: Sanches, Madalena, Cunha Velho, Glória, Alves, Rosário, Selores, Manuela
• Format: Article
• Language: por
• Source: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Download full: https://doi.org/10.29021/spdv.73.3.465
• topic: Erythema Multiforme/chemically induced; Sertraline/adverse effects; Eritema multiforme/induzido quimicamente; Sertralina/reacções adversas

Sertraline is frequently used for treatment of depressive and anxiety syndromes. Side effects are usually transient, and dose-dependent. We describe the case of a 76-year-old woman with depressive syndrome, and a history of recent introduction of sertraline who came to the emergency department with fever, and a cutaneous rash with two days of evolution. On examination, we noticed erythematous target papules, and exulcerations of oral mucosa. A skin biopsy was performed for histopathological examination with diagnosis of major multiforme erythema associated with sertraline. The patient stopped the drug in question, and initiated oral prednisolone with good resolution. Although uncommon, there are reported cases of severe skin reaction consequent to sertraline.