Antimicrobial resistance and virulence profiles of Enterobacterales isolated from two-finger and three-finger sloths (Choloepus hoffmanni and Bradypus variegatus) of Costa Rica

Detalhes bibliográficos
Autor(a) principal: Fernandes, Matilde
Data de Publicação: 2022
Outros Autores: Carneiro, Carla, Villada Rosales, Ana Maria, Grilo, Miguel, Ramiro, Yolanda, Cunha, Eva, Nunes, Telmo, Tavares, Luis, Sandi, Janet, Oliveira, Manuela
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/24147
Resumo: Research Areas: Science & Technology ; Other Topics
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spelling Antimicrobial resistance and virulence profiles of Enterobacterales isolated from two-finger and three-finger sloths (Choloepus hoffmanni and Bradypus variegatus) of Costa RicaAntimicrobial resistanceBacterial virulence factorsWildlife bacteriaOne healthCholoepus hoffmanniBradypus variegatusResearch Areas: Science & Technology ; Other TopicsBackground: Wildlife has been recently recognized as an environmental reservoir for antimicrobial resistance (AMR). However, less information on this topic is available in animals released back into the wild after rehabilitation in wildlife facilities, compared with studies performed exclusively in captive or free-ranging wildlife. This study aimed to evaluate the potential influence of captivity and/or treatment while in captivity of wild sloths on the AMR and virulence profiles of sloths’ Enterobacterales. Methods: Oral and rectal swab samples were collected from 39 two-finger (Choloepus hoffmanni) and three-finger sloths (Bradypus variegatus) of Costa Rica (n = 78) and analyzed using conventional bacteriological techniques. A generalized linear mixed model was applied to estimate the isolates’ multiple antimicrobial resistance and virulence indices as a function of animal status. Results: A considerable level of resistance was detected, especially for Citrobacter youngae and Escherichia coli, with 17.5% of isolates classified as multidrug-resistant. Virulence indices of isolates from rehabilitated sloths were significantly higher than the ones from sloths being hand-reared for shorter periods. Conclusions: To our knowledge, this is the first description of sloths’ antimicrobial resistant Enterobacterales, suggesting that sloths’ rehabilitation and consequent exposure to humans, may promote the selection of bacteria with higher virulence. Ultimately, these bacteria may represent a threat to human and animal health due to their zoonotic potential and AMR and virulence profiles.PEERJ INCRepositório da Universidade de LisboaFernandes, MatildeCarneiro, CarlaVillada Rosales, Ana MariaGrilo, MiguelRamiro, YolandaCunha, EvaNunes, TelmoTavares, LuisSandi, JanetOliveira, Manuela2022-04-22T23:19:25Z2022-03-112022-03-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/24147engFernandes M, Nóbrega Carneiro C, Villada Rosales AM, Grilo M, Ramiro Y, Cunha E, Nunes T, Tavares L, Sandi J, Oliveira M. 2022. Antimicrobial resistance and virulence profiles of Enterobacterales isolated from two-finger and three-finger sloths (Choloepus hoffmanni and Bradypus variegatus) of Costa Rica. PeerJ, 10:e12911. Doi 10.7717/peerj.129112167-835910.7717/peerj.12911info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:53:48Zoai:www.repository.utl.pt:10400.5/24147Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:08:15.662764Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Antimicrobial resistance and virulence profiles of Enterobacterales isolated from two-finger and three-finger sloths (Choloepus hoffmanni and Bradypus variegatus) of Costa Rica
title Antimicrobial resistance and virulence profiles of Enterobacterales isolated from two-finger and three-finger sloths (Choloepus hoffmanni and Bradypus variegatus) of Costa Rica
spellingShingle Antimicrobial resistance and virulence profiles of Enterobacterales isolated from two-finger and three-finger sloths (Choloepus hoffmanni and Bradypus variegatus) of Costa Rica
Fernandes, Matilde
Antimicrobial resistance
Bacterial virulence factors
Wildlife bacteria
One health
Choloepus hoffmanni
Bradypus variegatus
title_short Antimicrobial resistance and virulence profiles of Enterobacterales isolated from two-finger and three-finger sloths (Choloepus hoffmanni and Bradypus variegatus) of Costa Rica
title_full Antimicrobial resistance and virulence profiles of Enterobacterales isolated from two-finger and three-finger sloths (Choloepus hoffmanni and Bradypus variegatus) of Costa Rica
title_fullStr Antimicrobial resistance and virulence profiles of Enterobacterales isolated from two-finger and three-finger sloths (Choloepus hoffmanni and Bradypus variegatus) of Costa Rica
title_full_unstemmed Antimicrobial resistance and virulence profiles of Enterobacterales isolated from two-finger and three-finger sloths (Choloepus hoffmanni and Bradypus variegatus) of Costa Rica
title_sort Antimicrobial resistance and virulence profiles of Enterobacterales isolated from two-finger and three-finger sloths (Choloepus hoffmanni and Bradypus variegatus) of Costa Rica
author Fernandes, Matilde
author_facet Fernandes, Matilde
Carneiro, Carla
Villada Rosales, Ana Maria
Grilo, Miguel
Ramiro, Yolanda
Cunha, Eva
Nunes, Telmo
Tavares, Luis
Sandi, Janet
Oliveira, Manuela
author_role author
author2 Carneiro, Carla
Villada Rosales, Ana Maria
Grilo, Miguel
Ramiro, Yolanda
Cunha, Eva
Nunes, Telmo
Tavares, Luis
Sandi, Janet
Oliveira, Manuela
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Fernandes, Matilde
Carneiro, Carla
Villada Rosales, Ana Maria
Grilo, Miguel
Ramiro, Yolanda
Cunha, Eva
Nunes, Telmo
Tavares, Luis
Sandi, Janet
Oliveira, Manuela
dc.subject.por.fl_str_mv Antimicrobial resistance
Bacterial virulence factors
Wildlife bacteria
One health
Choloepus hoffmanni
Bradypus variegatus
topic Antimicrobial resistance
Bacterial virulence factors
Wildlife bacteria
One health
Choloepus hoffmanni
Bradypus variegatus
description Research Areas: Science & Technology ; Other Topics
publishDate 2022
dc.date.none.fl_str_mv 2022-04-22T23:19:25Z
2022-03-11
2022-03-11T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/24147
url http://hdl.handle.net/10400.5/24147
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Fernandes M, Nóbrega Carneiro C, Villada Rosales AM, Grilo M, Ramiro Y, Cunha E, Nunes T, Tavares L, Sandi J, Oliveira M. 2022. Antimicrobial resistance and virulence profiles of Enterobacterales isolated from two-finger and three-finger sloths (Choloepus hoffmanni and Bradypus variegatus) of Costa Rica. PeerJ, 10:e12911. Doi 10.7717/peerj.12911
2167-8359
10.7717/peerj.12911
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv PEERJ INC
publisher.none.fl_str_mv PEERJ INC
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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