Male infertility in the XXI century: are obesogens to blame?

• Autor(a) principal: Sousa, Ana Catarina A.
• Data de Publicação: 2022
• Outros Autores: Alves, M.G., Ferreira, P.F., Silva, B.M., Rato, L.
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10174/32904; https://doi.org/Sousa ACA, Alves MG, Ferreira PF, Silva BM, Rato L (2022) Male infertility in the XXI century: are obesogens to blame? International Journal of Molecular Sciences, Special Issue “Endocrine Disruption and Human Diseases” 23 (6): 3046; https://doi.org/10.3390/ijms23063046; https://doi.org/10.3390/ijms23063046

The permanent exposure to environmental contaminants promoting weight gain (i.e., obesogens) has raised serious health concerns. Evidence suggests that obesogens are one of the leading causes of the marked decline in male fertility and are key players in shaping future health outcomes, not only for those who are directly exposed to them, but also for upcoming generations. It has been hypothesized that obesogens affect male fertility. By using an interdisciplinary strategy, combining in silico, in vitro, in vivo and epidemiological findings, this review aims to contribute to the biological understanding of the molecular transformations induced by obesogens that are the basis of male infertility. Such understanding is shaped by the use of Adverse Outcomes Pathways, a new approach that may shift the paradigm of reproductive toxicology, contributing to the improvement of the diagnosis and management of the adverse effects of obesogens in male fertility.