Magnetoliposomes containing calcium ferrite nanoparticles for applications in breast cancer therapy

Detalhes bibliográficos
Autor(a) principal: Pereira, Daniela S. M.
Data de Publicação: 2019
Outros Autores: Cardoso, Beatriz D., Rodrigues, Ana Rita O., Amorim, Carlos O., Amaral, Vítor S., Almeida, B. G., Queiroz, Maria João R. P., Martinho, Olga, Baltazar, Fátima, Calhelha, Ricardo C., Ferreira, Isabel C. F. R., Coutinho, Paulo J. G., Castanheira, Elisabete M. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/61481
Resumo: Magnetoliposomes containing calcium ferrite (CaFe<sub>2</sub>O<sub>4</sub>) nanoparticles were developed and characterized for the first time. CaFe<sub>2</sub>O<sub>4 </sub>nanoparticles were covered by a lipid bilayer or entrapped in liposomes forming, respectively, solid or aqueous magnetoliposomes as nanocarriers for new antitumor drugs. The magnetic nanoparticles were characterized by UV/Visible absorption, XRD, HR-TEM, and SQUID, exhibiting sizes of 5.2 ± 1.2 nm (from TEM) and a superparamagnetic behavior. The magnetoliposomes were characterized by DLS and TEM. The incorporation of two new potential antitumor drugs (thienopyridine derivatives) specifically active against breast cancer in these nanosystems was investigated by fluorescence emission and anisotropy. Aqueous magnetoliposomes, with hydrodynamic diameters around 130 nm, and solid magnetoliposomes with sizes of ca. 170 nm, interact with biomembranes by fusion and are able to transport the antitumor drugs with generally high encapsulation efficiencies (70%). These fully biocompatible drug-loaded magnetoliposomes can be promising as therapeutic agents in future applications of combined breast cancer therapy.
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spelling Magnetoliposomes containing calcium ferrite nanoparticles for applications in breast cancer therapycalcium ferrite nanoparticlesmagnetoliposomesnew antitumor drugsthienopyridine derivativesbreast cancer therapyScience & TechnologyMagnetoliposomes containing calcium ferrite (CaFe<sub>2</sub>O<sub>4</sub>) nanoparticles were developed and characterized for the first time. CaFe<sub>2</sub>O<sub>4 </sub>nanoparticles were covered by a lipid bilayer or entrapped in liposomes forming, respectively, solid or aqueous magnetoliposomes as nanocarriers for new antitumor drugs. The magnetic nanoparticles were characterized by UV/Visible absorption, XRD, HR-TEM, and SQUID, exhibiting sizes of 5.2 ± 1.2 nm (from TEM) and a superparamagnetic behavior. The magnetoliposomes were characterized by DLS and TEM. The incorporation of two new potential antitumor drugs (thienopyridine derivatives) specifically active against breast cancer in these nanosystems was investigated by fluorescence emission and anisotropy. Aqueous magnetoliposomes, with hydrodynamic diameters around 130 nm, and solid magnetoliposomes with sizes of ca. 170 nm, interact with biomembranes by fusion and are able to transport the antitumor drugs with generally high encapsulation efficiencies (70%). These fully biocompatible drug-loaded magnetoliposomes can be promising as therapeutic agents in future applications of combined breast cancer therapy.This research was funded by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding of CF-UM-UP (UID/FIS/04650/2013; UID/FIS/04650/2019), CQUM (UID/QUI/00686/2016; UID/QUI/00686/2019) and LA-26 (PEst-C/SAU/LA0026/2013), and through the research project PTDC/QUI-QFI/28020/2017 (POCI-01-0145-FEDER-028020), financed by FCT, European Fund of Regional Development (FEDER), COMPETE2020 and Portugal2020. The magnetic measurements were supported by projects UTAP-EXPL/NTec/0046/2017, NORTE-01-0145-FEDER-028538 e PTDC/FIS-MAC/29454/2017. The APC was also funded by FCT. B.D.C. acknowledges FCT for a PhD grant (SFRH/BD/141936/2018).Multidisciplinary Digital Publishing InstituteUniversidade do MinhoPereira, Daniela S. M.Cardoso, Beatriz D.Rodrigues, Ana Rita O.Amorim, Carlos O.Amaral, Vítor S.Almeida, B. G.Queiroz, Maria João R. P.Martinho, OlgaBaltazar, FátimaCalhelha, Ricardo C.Ferreira, Isabel C. F. R.Coutinho, Paulo J. G.Castanheira, Elisabete M. S.20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/61481engPereira, D.S.M.; Cardoso, B.D.; Rodrigues, A.R.O.; Amorim, C.O.; Amaral, V.S.; Almeida, B.G.; Queiroz, M.-J.; Martinho, O.; Baltazar, F.; Calhelha, R.C.; Ferreira, I.C.F.R.; Coutinho, P.J.G.; Castanheira, E.M.S. Magnetoliposomes Containing Calcium Ferrite Nanoparticles for Applications in Breast Cancer Therapy. Pharmaceutics 2019, 11, 477.1999-492310.3390/pharmaceutics11090477https://www.mdpi.com/1999-4923/11/9/477info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:42:48ZPortal AgregadorONG
dc.title.none.fl_str_mv Magnetoliposomes containing calcium ferrite nanoparticles for applications in breast cancer therapy
title Magnetoliposomes containing calcium ferrite nanoparticles for applications in breast cancer therapy
spellingShingle Magnetoliposomes containing calcium ferrite nanoparticles for applications in breast cancer therapy
Pereira, Daniela S. M.
calcium ferrite nanoparticles
magnetoliposomes
new antitumor drugs
thienopyridine derivatives
breast cancer therapy
Science & Technology
title_short Magnetoliposomes containing calcium ferrite nanoparticles for applications in breast cancer therapy
title_full Magnetoliposomes containing calcium ferrite nanoparticles for applications in breast cancer therapy
title_fullStr Magnetoliposomes containing calcium ferrite nanoparticles for applications in breast cancer therapy
title_full_unstemmed Magnetoliposomes containing calcium ferrite nanoparticles for applications in breast cancer therapy
title_sort Magnetoliposomes containing calcium ferrite nanoparticles for applications in breast cancer therapy
author Pereira, Daniela S. M.
author_facet Pereira, Daniela S. M.
Cardoso, Beatriz D.
Rodrigues, Ana Rita O.
Amorim, Carlos O.
Amaral, Vítor S.
Almeida, B. G.
Queiroz, Maria João R. P.
Martinho, Olga
Baltazar, Fátima
Calhelha, Ricardo C.
Ferreira, Isabel C. F. R.
Coutinho, Paulo J. G.
Castanheira, Elisabete M. S.
author_role author
author2 Cardoso, Beatriz D.
Rodrigues, Ana Rita O.
Amorim, Carlos O.
Amaral, Vítor S.
Almeida, B. G.
Queiroz, Maria João R. P.
Martinho, Olga
Baltazar, Fátima
Calhelha, Ricardo C.
Ferreira, Isabel C. F. R.
Coutinho, Paulo J. G.
Castanheira, Elisabete M. S.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Pereira, Daniela S. M.
Cardoso, Beatriz D.
Rodrigues, Ana Rita O.
Amorim, Carlos O.
Amaral, Vítor S.
Almeida, B. G.
Queiroz, Maria João R. P.
Martinho, Olga
Baltazar, Fátima
Calhelha, Ricardo C.
Ferreira, Isabel C. F. R.
Coutinho, Paulo J. G.
Castanheira, Elisabete M. S.
dc.subject.por.fl_str_mv calcium ferrite nanoparticles
magnetoliposomes
new antitumor drugs
thienopyridine derivatives
breast cancer therapy
Science & Technology
topic calcium ferrite nanoparticles
magnetoliposomes
new antitumor drugs
thienopyridine derivatives
breast cancer therapy
Science & Technology
description Magnetoliposomes containing calcium ferrite (CaFe<sub>2</sub>O<sub>4</sub>) nanoparticles were developed and characterized for the first time. CaFe<sub>2</sub>O<sub>4 </sub>nanoparticles were covered by a lipid bilayer or entrapped in liposomes forming, respectively, solid or aqueous magnetoliposomes as nanocarriers for new antitumor drugs. The magnetic nanoparticles were characterized by UV/Visible absorption, XRD, HR-TEM, and SQUID, exhibiting sizes of 5.2 ± 1.2 nm (from TEM) and a superparamagnetic behavior. The magnetoliposomes were characterized by DLS and TEM. The incorporation of two new potential antitumor drugs (thienopyridine derivatives) specifically active against breast cancer in these nanosystems was investigated by fluorescence emission and anisotropy. Aqueous magnetoliposomes, with hydrodynamic diameters around 130 nm, and solid magnetoliposomes with sizes of ca. 170 nm, interact with biomembranes by fusion and are able to transport the antitumor drugs with generally high encapsulation efficiencies (70%). These fully biocompatible drug-loaded magnetoliposomes can be promising as therapeutic agents in future applications of combined breast cancer therapy.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/61481
url http://hdl.handle.net/1822/61481
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pereira, D.S.M.; Cardoso, B.D.; Rodrigues, A.R.O.; Amorim, C.O.; Amaral, V.S.; Almeida, B.G.; Queiroz, M.-J.; Martinho, O.; Baltazar, F.; Calhelha, R.C.; Ferreira, I.C.F.R.; Coutinho, P.J.G.; Castanheira, E.M.S. Magnetoliposomes Containing Calcium Ferrite Nanoparticles for Applications in Breast Cancer Therapy. Pharmaceutics 2019, 11, 477.
1999-4923
10.3390/pharmaceutics11090477
https://www.mdpi.com/1999-4923/11/9/477
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.mail.fl_str_mv
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