Clinical Salmonella Typhimurium ST34 with metal tolerance genes and an IncHI2 plasmid carrying oqxAB-aac(6')-Ib-cr from Europe

Detalhes bibliográficos
Autor(a) principal: Campos, Joana
Data de Publicação: 2016
Outros Autores: Mourão, Joana, Marçal, Sara, Machado, Jorge, Novais, Carla, Peixe, Luísa, Antunes, Patrícia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/4554
Resumo: Fluoroquinolones are critical antibiotics for treating severe Salmonella infections, and the widespread of resistant isolates included in diverse epidemiological scenarios and carrying plasmid-mediated quinolone resistance (PMQR) is a global threat. Among PMQR mechanisms, those encoded by oqxAB and aac(6′)-Ib-cr genes are of special concern as they also confer reduced susceptibility to other antibiotics (oqxAB: chloramphenicol, trimethoprim, olaquindox; aac(6′)-Ib-cr: aminoglycosides) and biocides [oqxAB: quaternary ammonium compounds (QACs)].2,3 Although oqxAB ± aac(6′)-Ib-cr are prevalent and widespread in Asia, where olaquindox is still widely used in animal production, they remain scarce in Europe. Here we describe the molecular characterization of clinical ciprofloxacin-resistant Salmonella enterica Typhimurium with concomitant presence of oqxAB and aac(6′)-Ib-cr recovered for the first time in Europe.
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spelling Clinical Salmonella Typhimurium ST34 with metal tolerance genes and an IncHI2 plasmid carrying oqxAB-aac(6')-Ib-cr from EuropeAnti-Bacterial AgentsChild, PreschoolElectrophoresis, Gel, Pulsed-FieldEuropeFecesGene OrderGenotypeHumansInfantMetalsMicrobial Sensitivity TestsMolecular TypingPlasmidsSalmonella InfectionsSalmonella typhimuriumSequence Analysis, DNADrug Resistance, BacterialGenes, BacterialInfecções GastrointestinaisFluoroquinolones are critical antibiotics for treating severe Salmonella infections, and the widespread of resistant isolates included in diverse epidemiological scenarios and carrying plasmid-mediated quinolone resistance (PMQR) is a global threat. Among PMQR mechanisms, those encoded by oqxAB and aac(6′)-Ib-cr genes are of special concern as they also confer reduced susceptibility to other antibiotics (oqxAB: chloramphenicol, trimethoprim, olaquindox; aac(6′)-Ib-cr: aminoglycosides) and biocides [oqxAB: quaternary ammonium compounds (QACs)].2,3 Although oqxAB ± aac(6′)-Ib-cr are prevalent and widespread in Asia, where olaquindox is still widely used in animal production, they remain scarce in Europe. Here we describe the molecular characterization of clinical ciprofloxacin-resistant Salmonella enterica Typhimurium with concomitant presence of oqxAB and aac(6′)-Ib-cr recovered for the first time in Europe.This work was supported by a research grant from the Fundação para a Ciência e a Tecnologia (grant number UID/Multi/04378/2013). J. Campos and J. Mourão were supported by PhD fellowships from Fundac¸a˜o para a Cieˆncia e a Tecnologia (grant numbers SFRH/BD/93091/2013 and SFRH/ BD/77518/2011, respectively).Oxford University Press/ British Society for Antimicrobial ChemotherapyRepositório Científico do Instituto Nacional de SaúdeCampos, JoanaMourão, JoanaMarçal, SaraMachado, JorgeNovais, CarlaPeixe, LuísaAntunes, Patrícia2017-03-07T16:49:30Z2016-032016-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/4554engJ Antimicrob Chemother. 2016 Mar;71(3):843-5. doi: 10.1093/jac/dkv409. Epub 2015 Dec 170305-745310.1093/jac/dkv409info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:24Zoai:repositorio.insa.pt:10400.18/4554Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:39:20.497007Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Clinical Salmonella Typhimurium ST34 with metal tolerance genes and an IncHI2 plasmid carrying oqxAB-aac(6')-Ib-cr from Europe
title Clinical Salmonella Typhimurium ST34 with metal tolerance genes and an IncHI2 plasmid carrying oqxAB-aac(6')-Ib-cr from Europe
spellingShingle Clinical Salmonella Typhimurium ST34 with metal tolerance genes and an IncHI2 plasmid carrying oqxAB-aac(6')-Ib-cr from Europe
Campos, Joana
Anti-Bacterial Agents
Child, Preschool
Electrophoresis, Gel, Pulsed-Field
Europe
Feces
Gene Order
Genotype
Humans
Infant
Metals
Microbial Sensitivity Tests
Molecular Typing
Plasmids
Salmonella Infections
Salmonella typhimurium
Sequence Analysis, DNA
Drug Resistance, Bacterial
Genes, Bacterial
Infecções Gastrointestinais
title_short Clinical Salmonella Typhimurium ST34 with metal tolerance genes and an IncHI2 plasmid carrying oqxAB-aac(6')-Ib-cr from Europe
title_full Clinical Salmonella Typhimurium ST34 with metal tolerance genes and an IncHI2 plasmid carrying oqxAB-aac(6')-Ib-cr from Europe
title_fullStr Clinical Salmonella Typhimurium ST34 with metal tolerance genes and an IncHI2 plasmid carrying oqxAB-aac(6')-Ib-cr from Europe
title_full_unstemmed Clinical Salmonella Typhimurium ST34 with metal tolerance genes and an IncHI2 plasmid carrying oqxAB-aac(6')-Ib-cr from Europe
title_sort Clinical Salmonella Typhimurium ST34 with metal tolerance genes and an IncHI2 plasmid carrying oqxAB-aac(6')-Ib-cr from Europe
author Campos, Joana
author_facet Campos, Joana
Mourão, Joana
Marçal, Sara
Machado, Jorge
Novais, Carla
Peixe, Luísa
Antunes, Patrícia
author_role author
author2 Mourão, Joana
Marçal, Sara
Machado, Jorge
Novais, Carla
Peixe, Luísa
Antunes, Patrícia
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Campos, Joana
Mourão, Joana
Marçal, Sara
Machado, Jorge
Novais, Carla
Peixe, Luísa
Antunes, Patrícia
dc.subject.por.fl_str_mv Anti-Bacterial Agents
Child, Preschool
Electrophoresis, Gel, Pulsed-Field
Europe
Feces
Gene Order
Genotype
Humans
Infant
Metals
Microbial Sensitivity Tests
Molecular Typing
Plasmids
Salmonella Infections
Salmonella typhimurium
Sequence Analysis, DNA
Drug Resistance, Bacterial
Genes, Bacterial
Infecções Gastrointestinais
topic Anti-Bacterial Agents
Child, Preschool
Electrophoresis, Gel, Pulsed-Field
Europe
Feces
Gene Order
Genotype
Humans
Infant
Metals
Microbial Sensitivity Tests
Molecular Typing
Plasmids
Salmonella Infections
Salmonella typhimurium
Sequence Analysis, DNA
Drug Resistance, Bacterial
Genes, Bacterial
Infecções Gastrointestinais
description Fluoroquinolones are critical antibiotics for treating severe Salmonella infections, and the widespread of resistant isolates included in diverse epidemiological scenarios and carrying plasmid-mediated quinolone resistance (PMQR) is a global threat. Among PMQR mechanisms, those encoded by oqxAB and aac(6′)-Ib-cr genes are of special concern as they also confer reduced susceptibility to other antibiotics (oqxAB: chloramphenicol, trimethoprim, olaquindox; aac(6′)-Ib-cr: aminoglycosides) and biocides [oqxAB: quaternary ammonium compounds (QACs)].2,3 Although oqxAB ± aac(6′)-Ib-cr are prevalent and widespread in Asia, where olaquindox is still widely used in animal production, they remain scarce in Europe. Here we describe the molecular characterization of clinical ciprofloxacin-resistant Salmonella enterica Typhimurium with concomitant presence of oqxAB and aac(6′)-Ib-cr recovered for the first time in Europe.
publishDate 2016
dc.date.none.fl_str_mv 2016-03
2016-03-01T00:00:00Z
2017-03-07T16:49:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/4554
url http://hdl.handle.net/10400.18/4554
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Antimicrob Chemother. 2016 Mar;71(3):843-5. doi: 10.1093/jac/dkv409. Epub 2015 Dec 17
0305-7453
10.1093/jac/dkv409
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press/ British Society for Antimicrobial Chemotherapy
publisher.none.fl_str_mv Oxford University Press/ British Society for Antimicrobial Chemotherapy
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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