The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition.

Detalhes bibliográficos
Autor(a) principal: Bessa, J. M.
Data de Publicação: 2014
Outros Autores: Pinto, Luisa, Morais, Mónica, Sousa, Nuno, Patrício, P., Pinheiro, António Mateus, Almeida, Susana, Filipe, Augusto, Pedroso, Pedro, Santos, Paulo A. R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/32362
Resumo: Online first version - Oct 14, 2014
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spelling The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition.DepressionPirlindoleFluoxetinStressNeuroplasticityHippocampusNeurogenesisfluoxetineScience & TechnologyOnline first version - Oct 14, 2014There is accumulating evidence that adult neurogenesis and dendritic plasticity in the hippocampus are neuroplastic phenomena, highly sensitive to the effects of chronic stress and treatment with most classes of antidepressant drugs, being involved in the onset and recovery from depression. However, the effects of antidepressants that act through the selective inhibition of monoamine oxidase subtype A (MAO-A) in these phenomena are still largely unknown. In the present study, adult neurogenesis and neuronal morphology were examined in the hippocampus of rats exposed to chronic mild stress (CMS) and treated with the selective reversible MAO-A inhibitor (RIMA) drug, pirlindole and the selective serotonin reuptake inhibitor (SSRI), fluoxetine. The results provide the first demonstration that selective MAO-A inhibition with pirlindole is able to revert the behavioural effects of stress exposure while promoting hippocampal adult neurogenesis and rescuing the stress-induced dendritic atrophy of granule neurons.This research was funded by a collaborative research project established between ICVS and Grupo Tecnimede.SAGEUniversidade do MinhoBessa, J. M.Pinto, LuisaMorais, MónicaSousa, NunoPatrício, P.Pinheiro, António MateusAlmeida, SusanaFilipe, AugustoPedroso, PedroSantos, Paulo A. R.2014-122014-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/32362eng1432-207210.1177/026988111455364625315831www.springer.cominfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:22:46Zoai:repositorium.sdum.uminho.pt:1822/32362Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:16:19.927114Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition.
title The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition.
spellingShingle The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition.
Bessa, J. M.
Depression
Pirlindole
Fluoxetin
Stress
Neuroplasticity
Hippocampus
Neurogenesis
fluoxetine
Science & Technology
title_short The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition.
title_full The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition.
title_fullStr The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition.
title_full_unstemmed The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition.
title_sort The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition.
author Bessa, J. M.
author_facet Bessa, J. M.
Pinto, Luisa
Morais, Mónica
Sousa, Nuno
Patrício, P.
Pinheiro, António Mateus
Almeida, Susana
Filipe, Augusto
Pedroso, Pedro
Santos, Paulo A. R.
author_role author
author2 Pinto, Luisa
Morais, Mónica
Sousa, Nuno
Patrício, P.
Pinheiro, António Mateus
Almeida, Susana
Filipe, Augusto
Pedroso, Pedro
Santos, Paulo A. R.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Bessa, J. M.
Pinto, Luisa
Morais, Mónica
Sousa, Nuno
Patrício, P.
Pinheiro, António Mateus
Almeida, Susana
Filipe, Augusto
Pedroso, Pedro
Santos, Paulo A. R.
dc.subject.por.fl_str_mv Depression
Pirlindole
Fluoxetin
Stress
Neuroplasticity
Hippocampus
Neurogenesis
fluoxetine
Science & Technology
topic Depression
Pirlindole
Fluoxetin
Stress
Neuroplasticity
Hippocampus
Neurogenesis
fluoxetine
Science & Technology
description Online first version - Oct 14, 2014
publishDate 2014
dc.date.none.fl_str_mv 2014-12
2014-12-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/32362
url http://hdl.handle.net/1822/32362
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1432-2072
10.1177/0269881114553646
25315831
www.springer.com
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SAGE
publisher.none.fl_str_mv SAGE
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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