Determination of the optimum operating time for batch isothermal performance of enzyme-catalyzed multisubstrate reactions
Autor(a) principal: | |
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Data de Publicação: | 1994 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/6728 |
Resumo: | This communication consists of a mathematical analysis encompassing the maximization of the average rate of monomer production in a batch reactor performing an enzymatic reaction in a system consisting of a multiplicity of polymeric substrates which compete with one another for the active site of a soluble enzyme, under the assumption that the form of the rate expression is consistent with the Michaelis-Menten mechanism. The general form for the functional dependence of the various substrate concentrations on time is obtained in dimensionless form using matrix terminology; the optimum batch time is found for a simpler situation and the effect of various process and system variables thereon is discussed. The reasoning developed here emphasizes, in a quantitative fashion, the fact that the commonly used lumped substrate approaches lead to nonconservative decisions in industrial practice, and hence should be avoided when searching for trustworthy estimates of optimum operation. |
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Determination of the optimum operating time for batch isothermal performance of enzyme-catalyzed multisubstrate reactionsThis communication consists of a mathematical analysis encompassing the maximization of the average rate of monomer production in a batch reactor performing an enzymatic reaction in a system consisting of a multiplicity of polymeric substrates which compete with one another for the active site of a soluble enzyme, under the assumption that the form of the rate expression is consistent with the Michaelis-Menten mechanism. The general form for the functional dependence of the various substrate concentrations on time is obtained in dimensionless form using matrix terminology; the optimum batch time is found for a simpler situation and the effect of various process and system variables thereon is discussed. The reasoning developed here emphasizes, in a quantitative fashion, the fact that the commonly used lumped substrate approaches lead to nonconservative decisions in industrial practice, and hence should be avoided when searching for trustworthy estimates of optimum operation.Springer VerlagVeritati - Repositório Institucional da Universidade Católica PortuguesaMalcata, F. Xavier2011-10-21T15:47:20Z19941994-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/6728engMALCATA, F. Xavier - Determination of the optimum operating time for batch isothermal performance of enzyme-catalyzed multisubstrate reactions. Bioprocess and Biosystems Engineering. ISSN 1615-7605. 10:4 (1994) 173-17810.1007/BF003875260028268765A1994NH30200005info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-12T17:11:11Zoai:repositorio.ucp.pt:10400.14/6728Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:06:14.609837Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Determination of the optimum operating time for batch isothermal performance of enzyme-catalyzed multisubstrate reactions |
title |
Determination of the optimum operating time for batch isothermal performance of enzyme-catalyzed multisubstrate reactions |
spellingShingle |
Determination of the optimum operating time for batch isothermal performance of enzyme-catalyzed multisubstrate reactions Malcata, F. Xavier |
title_short |
Determination of the optimum operating time for batch isothermal performance of enzyme-catalyzed multisubstrate reactions |
title_full |
Determination of the optimum operating time for batch isothermal performance of enzyme-catalyzed multisubstrate reactions |
title_fullStr |
Determination of the optimum operating time for batch isothermal performance of enzyme-catalyzed multisubstrate reactions |
title_full_unstemmed |
Determination of the optimum operating time for batch isothermal performance of enzyme-catalyzed multisubstrate reactions |
title_sort |
Determination of the optimum operating time for batch isothermal performance of enzyme-catalyzed multisubstrate reactions |
author |
Malcata, F. Xavier |
author_facet |
Malcata, F. Xavier |
author_role |
author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Malcata, F. Xavier |
description |
This communication consists of a mathematical analysis encompassing the maximization of the average rate of monomer production in a batch reactor performing an enzymatic reaction in a system consisting of a multiplicity of polymeric substrates which compete with one another for the active site of a soluble enzyme, under the assumption that the form of the rate expression is consistent with the Michaelis-Menten mechanism. The general form for the functional dependence of the various substrate concentrations on time is obtained in dimensionless form using matrix terminology; the optimum batch time is found for a simpler situation and the effect of various process and system variables thereon is discussed. The reasoning developed here emphasizes, in a quantitative fashion, the fact that the commonly used lumped substrate approaches lead to nonconservative decisions in industrial practice, and hence should be avoided when searching for trustworthy estimates of optimum operation. |
publishDate |
1994 |
dc.date.none.fl_str_mv |
1994 1994-01-01T00:00:00Z 2011-10-21T15:47:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/6728 |
url |
http://hdl.handle.net/10400.14/6728 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
MALCATA, F. Xavier - Determination of the optimum operating time for batch isothermal performance of enzyme-catalyzed multisubstrate reactions. Bioprocess and Biosystems Engineering. ISSN 1615-7605. 10:4 (1994) 173-178 10.1007/BF00387526 0028268765 A1994NH30200005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer Verlag |
publisher.none.fl_str_mv |
Springer Verlag |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799131728350019584 |