Relevance of physicochemical characterization in nanotoxicology studies

Detalhes bibliográficos
Autor(a) principal: Louro, Henriqueta
Data de Publicação: 2016
Outros Autores: Tavares, Ana, Pinhão, Mariana, Santos, Joana, Silva, M.J.
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/3816
Resumo: Nanomaterials (NMs) with the same chemistry can greatly differ by size, surface area, shape, stability, rigidness, coating or electrical charge and these characteristics affect nano-bio interactions, leading to different toxic potential. In this communication is shown that closely related NMs can have different genotoxic effects, evidencing the importance of investigating the toxic potential of each NM individually, instead of assuming a common mechanism and equal genotoxic effects for a set of similar NMs. The importance of considering complexity of in vivo systems in nanotoxicology, such as the use of tridimensional cellular models, air-liquid interface exposure or in vivo models that mimic human routes of exposure, is underlined.
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spelling Relevance of physicochemical characterization in nanotoxicology studiesGenotoxicidade AmbientalEnvironmental GenotoxicityNanomaterialsPhysicochemichal CharacterizationNanomaterials (NMs) with the same chemistry can greatly differ by size, surface area, shape, stability, rigidness, coating or electrical charge and these characteristics affect nano-bio interactions, leading to different toxic potential. In this communication is shown that closely related NMs can have different genotoxic effects, evidencing the importance of investigating the toxic potential of each NM individually, instead of assuming a common mechanism and equal genotoxic effects for a set of similar NMs. The importance of considering complexity of in vivo systems in nanotoxicology, such as the use of tridimensional cellular models, air-liquid interface exposure or in vivo models that mimic human routes of exposure, is underlined.Instituto Nacional de Saúde Doutor Ricardo Jorge, IPRepositório Científico do Instituto Nacional de SaúdeLouro, HenriquetaTavares, AnaPinhão, MarianaSantos, JoanaSilva, M.J.2016-05-24T16:15:42Z2016-04-082016-04-08T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectapplication/pdfhttp://hdl.handle.net/10400.18/3816enginfo:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:00Zoai:repositorio.insa.pt:10400.18/3816Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:38:38.448267Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Relevance of physicochemical characterization in nanotoxicology studies
title Relevance of physicochemical characterization in nanotoxicology studies
spellingShingle Relevance of physicochemical characterization in nanotoxicology studies
Louro, Henriqueta
Genotoxicidade Ambiental
Environmental Genotoxicity
Nanomaterials
Physicochemichal Characterization
title_short Relevance of physicochemical characterization in nanotoxicology studies
title_full Relevance of physicochemical characterization in nanotoxicology studies
title_fullStr Relevance of physicochemical characterization in nanotoxicology studies
title_full_unstemmed Relevance of physicochemical characterization in nanotoxicology studies
title_sort Relevance of physicochemical characterization in nanotoxicology studies
author Louro, Henriqueta
author_facet Louro, Henriqueta
Tavares, Ana
Pinhão, Mariana
Santos, Joana
Silva, M.J.
author_role author
author2 Tavares, Ana
Pinhão, Mariana
Santos, Joana
Silva, M.J.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Louro, Henriqueta
Tavares, Ana
Pinhão, Mariana
Santos, Joana
Silva, M.J.
dc.subject.por.fl_str_mv Genotoxicidade Ambiental
Environmental Genotoxicity
Nanomaterials
Physicochemichal Characterization
topic Genotoxicidade Ambiental
Environmental Genotoxicity
Nanomaterials
Physicochemichal Characterization
description Nanomaterials (NMs) with the same chemistry can greatly differ by size, surface area, shape, stability, rigidness, coating or electrical charge and these characteristics affect nano-bio interactions, leading to different toxic potential. In this communication is shown that closely related NMs can have different genotoxic effects, evidencing the importance of investigating the toxic potential of each NM individually, instead of assuming a common mechanism and equal genotoxic effects for a set of similar NMs. The importance of considering complexity of in vivo systems in nanotoxicology, such as the use of tridimensional cellular models, air-liquid interface exposure or in vivo models that mimic human routes of exposure, is underlined.
publishDate 2016
dc.date.none.fl_str_mv 2016-05-24T16:15:42Z
2016-04-08
2016-04-08T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/3816
url http://hdl.handle.net/10400.18/3816
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto Nacional de Saúde Doutor Ricardo Jorge, IP
publisher.none.fl_str_mv Instituto Nacional de Saúde Doutor Ricardo Jorge, IP
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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