Smart responsive microneedles for controlled drug delivery

Detalhes bibliográficos
Autor(a) principal: Qi, Zhenzhen
Data de Publicação: 2023
Outros Autores: Yan, Zheng, Tan, Guohongfang, Kundu, Subhas C, Lu, Shenzhou
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/89227
Resumo: As an emerging technology, microneedles offer advantages such as painless administration, good biocompatibility, and ease of self-administration, so as to effectively treat various diseases, such as diabetes, wound repair, tumor treatment and so on. How to regulate the release behavior of loaded drugs in polymer microneedles is the core element of transdermal drug delivery. As an emerging on-demand drug-delivery technology, intelligent responsive microneedles can achieve local accurate release of drugs according to external stimuli or internal physiological environment changes. This review focuses on the research efforts in smart responsive polymer microneedles at home and abroad in recent years. It summarizes the response mechanisms based on various stimuli and their respective application scenarios. Utilizing innovative, responsive microneedle systems offers a convenient and precise targeted drug delivery method, holding significant research implications in transdermal drug administration. Safety and efficacy will remain the key areas of continuous efforts for research scholars in the future.
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spelling Smart responsive microneedles for controlled drug deliveryControlled drug releaseMicroneedlesSmart responsivenessTransdermal deliveryAs an emerging technology, microneedles offer advantages such as painless administration, good biocompatibility, and ease of self-administration, so as to effectively treat various diseases, such as diabetes, wound repair, tumor treatment and so on. How to regulate the release behavior of loaded drugs in polymer microneedles is the core element of transdermal drug delivery. As an emerging on-demand drug-delivery technology, intelligent responsive microneedles can achieve local accurate release of drugs according to external stimuli or internal physiological environment changes. This review focuses on the research efforts in smart responsive polymer microneedles at home and abroad in recent years. It summarizes the response mechanisms based on various stimuli and their respective application scenarios. Utilizing innovative, responsive microneedle systems offers a convenient and precise targeted drug delivery method, holding significant research implications in transdermal drug administration. Safety and efficacy will remain the key areas of continuous efforts for research scholars in the future.This research was funded by College Nature Science Research Project of Jiangsu Province, China (Grant No. 20KJA540002) and Postgraduate Research & Practice Innovation Program of Jiangsu Province, China (Grant No. KYCX23-3257)MDPIUniversidade do MinhoQi, ZhenzhenYan, ZhengTan, GuohongfangKundu, Subhas CLu, Shenzhou2023-112023-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/89227engQi Z. Z., Yan Z., Tan G. H. F., Kundu S. C., Lu S. Z. Smart Responsive Microneedles for Controlled Drug Delivery, Molecules, Vol. 28, Issue 21, pp. 7411, doi:10.3390/molecules28217411, 20231420-304910.3390/molecules2821741137959830https://www.mdpi.com/1420-3049/28/21/7411info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-09T01:20:05Zoai:repositorium.sdum.uminho.pt:1822/89227Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:14:00.904348Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Smart responsive microneedles for controlled drug delivery
title Smart responsive microneedles for controlled drug delivery
spellingShingle Smart responsive microneedles for controlled drug delivery
Qi, Zhenzhen
Controlled drug release
Microneedles
Smart responsiveness
Transdermal delivery
title_short Smart responsive microneedles for controlled drug delivery
title_full Smart responsive microneedles for controlled drug delivery
title_fullStr Smart responsive microneedles for controlled drug delivery
title_full_unstemmed Smart responsive microneedles for controlled drug delivery
title_sort Smart responsive microneedles for controlled drug delivery
author Qi, Zhenzhen
author_facet Qi, Zhenzhen
Yan, Zheng
Tan, Guohongfang
Kundu, Subhas C
Lu, Shenzhou
author_role author
author2 Yan, Zheng
Tan, Guohongfang
Kundu, Subhas C
Lu, Shenzhou
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Qi, Zhenzhen
Yan, Zheng
Tan, Guohongfang
Kundu, Subhas C
Lu, Shenzhou
dc.subject.por.fl_str_mv Controlled drug release
Microneedles
Smart responsiveness
Transdermal delivery
topic Controlled drug release
Microneedles
Smart responsiveness
Transdermal delivery
description As an emerging technology, microneedles offer advantages such as painless administration, good biocompatibility, and ease of self-administration, so as to effectively treat various diseases, such as diabetes, wound repair, tumor treatment and so on. How to regulate the release behavior of loaded drugs in polymer microneedles is the core element of transdermal drug delivery. As an emerging on-demand drug-delivery technology, intelligent responsive microneedles can achieve local accurate release of drugs according to external stimuli or internal physiological environment changes. This review focuses on the research efforts in smart responsive polymer microneedles at home and abroad in recent years. It summarizes the response mechanisms based on various stimuli and their respective application scenarios. Utilizing innovative, responsive microneedle systems offers a convenient and precise targeted drug delivery method, holding significant research implications in transdermal drug administration. Safety and efficacy will remain the key areas of continuous efforts for research scholars in the future.
publishDate 2023
dc.date.none.fl_str_mv 2023-11
2023-11-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/89227
url https://hdl.handle.net/1822/89227
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Qi Z. Z., Yan Z., Tan G. H. F., Kundu S. C., Lu S. Z. Smart Responsive Microneedles for Controlled Drug Delivery, Molecules, Vol. 28, Issue 21, pp. 7411, doi:10.3390/molecules28217411, 2023
1420-3049
10.3390/molecules28217411
37959830
https://www.mdpi.com/1420-3049/28/21/7411
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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