Skeletal metastatic carcinoma: A case from 15th-20th century Coimbra, Portugal
Main Author: | |
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Publication Date: | 2011 |
Other Authors: | , |
Format: | Article |
Language: | eng |
Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Download full: | http://hdl.handle.net/10316/41160 https://doi.org/10.1002/oa.1130 |
Summary: | This paper discusses the differential diagnosis of unusual and distinct pathological changes in the skeletal remains of a +40 year old female from 15th-20th century Coimbra (Portugal). The most affected area seems to have been the skull, but multiple lesions, lytic and/or blastic, have been found throughout the post-cranial skeleton, more specifically, in the scapulae, clavicles, humerus, sternum, ribs, sacrum, innominates, and femurs. The differential diagnosis of the lesions gave rise to several possible pathological conditions, namely, Langerhans cell histiocytosis (granulomatosis or Histiocytosis X), multiple myeloma, and metastatic carcinoma. Various macroscopic and radiological aspects lead us to consider metastatic carcinoma as the most probable diagnose. Despite the argumentative identity of the possible primary lesion, age, sex and the mixed nature of the osseous response are consistent with cancer of the breast but do not exclude other carcinomas, namely lung cancer. With temporal and regional differences emerging in the frequency of malignant tumours, the identification of new cases becomes important, particularly from geographic areas where few cases have been reported. In fact, the present report adds to the only case of metastatic carcinoma detected in non-identified Portuguese human skeletal remains until now. |
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Skeletal metastatic carcinoma: A case from 15th-20th century Coimbra, PortugalCancerMalignant tumourMetastasesCoimbraPortugalThis paper discusses the differential diagnosis of unusual and distinct pathological changes in the skeletal remains of a +40 year old female from 15th-20th century Coimbra (Portugal). The most affected area seems to have been the skull, but multiple lesions, lytic and/or blastic, have been found throughout the post-cranial skeleton, more specifically, in the scapulae, clavicles, humerus, sternum, ribs, sacrum, innominates, and femurs. The differential diagnosis of the lesions gave rise to several possible pathological conditions, namely, Langerhans cell histiocytosis (granulomatosis or Histiocytosis X), multiple myeloma, and metastatic carcinoma. Various macroscopic and radiological aspects lead us to consider metastatic carcinoma as the most probable diagnose. Despite the argumentative identity of the possible primary lesion, age, sex and the mixed nature of the osseous response are consistent with cancer of the breast but do not exclude other carcinomas, namely lung cancer. With temporal and regional differences emerging in the frequency of malignant tumours, the identification of new cases becomes important, particularly from geographic areas where few cases have been reported. In fact, the present report adds to the only case of metastatic carcinoma detected in non-identified Portuguese human skeletal remains until now.2011info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/41160http://hdl.handle.net/10316/41160https://doi.org/10.1002/oa.1130https://doi.org/10.1002/oa.1130enghttp://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-1212Wasterlain, S. N.Ascenso, B. F.Silva, A. M.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-06-29T10:02:48Zoai:estudogeral.uc.pt:10316/41160Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:52:44.277290Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Skeletal metastatic carcinoma: A case from 15th-20th century Coimbra, Portugal |
title |
Skeletal metastatic carcinoma: A case from 15th-20th century Coimbra, Portugal |
spellingShingle |
Skeletal metastatic carcinoma: A case from 15th-20th century Coimbra, Portugal Wasterlain, S. N. Cancer Malignant tumour Metastases Coimbra Portugal |
title_short |
Skeletal metastatic carcinoma: A case from 15th-20th century Coimbra, Portugal |
title_full |
Skeletal metastatic carcinoma: A case from 15th-20th century Coimbra, Portugal |
title_fullStr |
Skeletal metastatic carcinoma: A case from 15th-20th century Coimbra, Portugal |
title_full_unstemmed |
Skeletal metastatic carcinoma: A case from 15th-20th century Coimbra, Portugal |
title_sort |
Skeletal metastatic carcinoma: A case from 15th-20th century Coimbra, Portugal |
author |
Wasterlain, S. N. |
author_facet |
Wasterlain, S. N. Ascenso, B. F. Silva, A. M. |
author_role |
author |
author2 |
Ascenso, B. F. Silva, A. M. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Wasterlain, S. N. Ascenso, B. F. Silva, A. M. |
dc.subject.por.fl_str_mv |
Cancer Malignant tumour Metastases Coimbra Portugal |
topic |
Cancer Malignant tumour Metastases Coimbra Portugal |
description |
This paper discusses the differential diagnosis of unusual and distinct pathological changes in the skeletal remains of a +40 year old female from 15th-20th century Coimbra (Portugal). The most affected area seems to have been the skull, but multiple lesions, lytic and/or blastic, have been found throughout the post-cranial skeleton, more specifically, in the scapulae, clavicles, humerus, sternum, ribs, sacrum, innominates, and femurs. The differential diagnosis of the lesions gave rise to several possible pathological conditions, namely, Langerhans cell histiocytosis (granulomatosis or Histiocytosis X), multiple myeloma, and metastatic carcinoma. Various macroscopic and radiological aspects lead us to consider metastatic carcinoma as the most probable diagnose. Despite the argumentative identity of the possible primary lesion, age, sex and the mixed nature of the osseous response are consistent with cancer of the breast but do not exclude other carcinomas, namely lung cancer. With temporal and regional differences emerging in the frequency of malignant tumours, the identification of new cases becomes important, particularly from geographic areas where few cases have been reported. In fact, the present report adds to the only case of metastatic carcinoma detected in non-identified Portuguese human skeletal remains until now. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/41160 http://hdl.handle.net/10316/41160 https://doi.org/10.1002/oa.1130 https://doi.org/10.1002/oa.1130 |
url |
http://hdl.handle.net/10316/41160 https://doi.org/10.1002/oa.1130 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-1212 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133815421009920 |