The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19

Detalhes bibliográficos
Autor(a) principal: Bruno, Raphael Romano
Data de Publicação: 2022
Outros Autores: Wernly, Bernhard, Flaatten, Hans, Fjølner, Jesper, Artigas, Antonio, Baldia, Philipp Heinrich, Binneboessel, Stephan, Bollen Pinto, Bernardo, Schefold, Joerg C, Wolff, Georg, Kelm, Malte, Beil, Michael, Sviri, Sigal, van Heerden, Peter Vernon, Szczeklik, Wojciech, Elhadi, Muhammed, Joannidis, Michael, Oeyen, Sandra, Kondili, Eumorfia, Marsh, Brian, Wollborn, Jakob, Andersen, Finn H, Moreno, Rui, Leaver, Susannah, Boumendil, Ariane, De Lange, Dylan W, Guidet, Bertrand, Jung, Christian
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/136062
Resumo: Open Access funding enabled and organized by Projekt DEAL. This study was endorsed by the ESICM. Free support for running the electronic database and was granted from the dep. of Epidemiology, University of Aarhus, Denmark. Bruno et al. Annals of Intensive Care (2022) 12:26 Page 10 of 11 The support of the study in France by a grant from Fondation Assistance Publique-Hôpitaux de Paris pour la recherche is greatly appreciated. In Norway, the study was supported by a grant from the Health Region West. In addition, the study was supported by a grant from the European Open Science Cloud (EOSC). EOSCsecretariat.eu has received funding from the European Union’s Horizon Programme call H2020-INFRAEOSC-05-2018-2019, grant agreement number 831644. This work was supported by the Collaborative Research Center SFB 1116 (German Research Foundation, DFG) and by the Forschungskommission of the Medical Faculty of the Heinrich-Heine-University Düsseldorf and No. 2020–21 to RRB for a Clinician Scientist Track. No (industry) sponsorship has been received for this investigator-initiated study.
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spelling The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19Open Access funding enabled and organized by Projekt DEAL. This study was endorsed by the ESICM. Free support for running the electronic database and was granted from the dep. of Epidemiology, University of Aarhus, Denmark. Bruno et al. Annals of Intensive Care (2022) 12:26 Page 10 of 11 The support of the study in France by a grant from Fondation Assistance Publique-Hôpitaux de Paris pour la recherche is greatly appreciated. In Norway, the study was supported by a grant from the Health Region West. In addition, the study was supported by a grant from the European Open Science Cloud (EOSC). EOSCsecretariat.eu has received funding from the European Union’s Horizon Programme call H2020-INFRAEOSC-05-2018-2019, grant agreement number 831644. This work was supported by the Collaborative Research Center SFB 1116 (German Research Foundation, DFG) and by the Forschungskommission of the Medical Faculty of the Heinrich-Heine-University Düsseldorf and No. 2020–21 to RRB for a Clinician Scientist Track. No (industry) sponsorship has been received for this investigator-initiated study.PURPOSE: Critically ill old intensive care unit (ICU) patients suffering from Sars-CoV-2 disease (COVID-19) are at increased risk for adverse outcomes. This post hoc analysis investigates the association of the Activities of Daily Living (ADL) with the outcome in this vulnerable patient group. METHODS: The COVIP study is a prospective international observational study that recruited ICU patients ≥ 70 years admitted with COVID-19 (NCT04321265). Several parameters including ADL (ADL; 0 = disability, 6 = no disability), Clinical Frailty Scale (CFS), SOFA score, intensive care treatment, ICU- and 3-month survival were recorded. A mixed-effects Weibull proportional hazard regression analyses for 3-month mortality adjusted for multiple confounders. RESULTS: This pre-specified analysis included 2359 patients with a documented ADL and CFS. Most patients evidenced independence in their daily living before hospital admission (80% with ADL = 6). Patients with no frailty and no disability showed the lowest, patients with frailty (CFS ≥ 5) and disability (ADL < 6) the highest 3-month mortality (52 vs. 78%, p < 0.001). ADL was independently associated with 3-month mortality (ADL as a continuous variable: aHR 0.88 (95% CI 0.82-0.94, p < 0.001). Being "disable" resulted in a significant increased risk for 3-month mortality (aHR 1.53 (95% CI 1.19-1.97, p 0.001) even after adjustment for multiple confounders. CONCLUSION: Baseline Activities of Daily Living (ADL) on admission provides additional information for outcome prediction, although most critically ill old intensive care patients suffering from COVID-19 had no restriction in their ADL prior to ICU admission. Combining frailty and disability identifies a subgroup with particularly high mortality. TRIAL REGISTRATION NUMBER: NCT04321265.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNBruno, Raphael RomanoWernly, BernhardFlaatten, HansFjølner, JesperArtigas, AntonioBaldia, Philipp HeinrichBinneboessel, StephanBollen Pinto, BernardoSchefold, Joerg CWolff, GeorgKelm, MalteBeil, MichaelSviri, Sigalvan Heerden, Peter VernonSzczeklik, WojciechElhadi, MuhammedJoannidis, MichaelOeyen, SandraKondili, EumorfiaMarsh, BrianWollborn, JakobAndersen, Finn HMoreno, RuiLeaver, SusannahBoumendil, ArianeDe Lange, Dylan WGuidet, BertrandJung, Christian2022-04-07T22:35:10Z2022-122022-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/136062eng2110-5820PURE: 42509066https://doi.org/10.1186/s13613-022-00996-9info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:14:20Zoai:run.unl.pt:10362/136062Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:48:37.283983Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19
title The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19
spellingShingle The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19
Bruno, Raphael Romano
title_short The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19
title_full The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19
title_fullStr The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19
title_full_unstemmed The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19
title_sort The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19
author Bruno, Raphael Romano
author_facet Bruno, Raphael Romano
Wernly, Bernhard
Flaatten, Hans
Fjølner, Jesper
Artigas, Antonio
Baldia, Philipp Heinrich
Binneboessel, Stephan
Bollen Pinto, Bernardo
Schefold, Joerg C
Wolff, Georg
Kelm, Malte
Beil, Michael
Sviri, Sigal
van Heerden, Peter Vernon
Szczeklik, Wojciech
Elhadi, Muhammed
Joannidis, Michael
Oeyen, Sandra
Kondili, Eumorfia
Marsh, Brian
Wollborn, Jakob
Andersen, Finn H
Moreno, Rui
Leaver, Susannah
Boumendil, Ariane
De Lange, Dylan W
Guidet, Bertrand
Jung, Christian
author_role author
author2 Wernly, Bernhard
Flaatten, Hans
Fjølner, Jesper
Artigas, Antonio
Baldia, Philipp Heinrich
Binneboessel, Stephan
Bollen Pinto, Bernardo
Schefold, Joerg C
Wolff, Georg
Kelm, Malte
Beil, Michael
Sviri, Sigal
van Heerden, Peter Vernon
Szczeklik, Wojciech
Elhadi, Muhammed
Joannidis, Michael
Oeyen, Sandra
Kondili, Eumorfia
Marsh, Brian
Wollborn, Jakob
Andersen, Finn H
Moreno, Rui
Leaver, Susannah
Boumendil, Ariane
De Lange, Dylan W
Guidet, Bertrand
Jung, Christian
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Bruno, Raphael Romano
Wernly, Bernhard
Flaatten, Hans
Fjølner, Jesper
Artigas, Antonio
Baldia, Philipp Heinrich
Binneboessel, Stephan
Bollen Pinto, Bernardo
Schefold, Joerg C
Wolff, Georg
Kelm, Malte
Beil, Michael
Sviri, Sigal
van Heerden, Peter Vernon
Szczeklik, Wojciech
Elhadi, Muhammed
Joannidis, Michael
Oeyen, Sandra
Kondili, Eumorfia
Marsh, Brian
Wollborn, Jakob
Andersen, Finn H
Moreno, Rui
Leaver, Susannah
Boumendil, Ariane
De Lange, Dylan W
Guidet, Bertrand
Jung, Christian
description Open Access funding enabled and organized by Projekt DEAL. This study was endorsed by the ESICM. Free support for running the electronic database and was granted from the dep. of Epidemiology, University of Aarhus, Denmark. Bruno et al. Annals of Intensive Care (2022) 12:26 Page 10 of 11 The support of the study in France by a grant from Fondation Assistance Publique-Hôpitaux de Paris pour la recherche is greatly appreciated. In Norway, the study was supported by a grant from the Health Region West. In addition, the study was supported by a grant from the European Open Science Cloud (EOSC). EOSCsecretariat.eu has received funding from the European Union’s Horizon Programme call H2020-INFRAEOSC-05-2018-2019, grant agreement number 831644. This work was supported by the Collaborative Research Center SFB 1116 (German Research Foundation, DFG) and by the Forschungskommission of the Medical Faculty of the Heinrich-Heine-University Düsseldorf and No. 2020–21 to RRB for a Clinician Scientist Track. No (industry) sponsorship has been received for this investigator-initiated study.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-07T22:35:10Z
2022-12
2022-12-01T00:00:00Z
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