Overview of proteomics studies in obstructive sleep apnea

Detalhes bibliográficos
Autor(a) principal: Feliciano, Amélia
Data de Publicação: 2015
Outros Autores: Torres, Vukosava M., Vaz, Fatima, Carvalho, Ana Sofia, Matthiesen, Rune, Pinto, Paula, Malhotra, Atul, Bárbara, Cristina, Penque, Deborah
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/3093
Resumo: Obstructive sleep apnea (OSA) is an underdiagnosed common public health concern causing deleterious effects on metabolic and cardiovascular health. Although much has been learned regarding the pathophysiology and consequences of OSA in the past decades, the molecular mechanisms associated with such processes remain poorly defined. The advanced high-throughput proteomics-based technologies have become a fundamental approach for identifying novel disease mediators as potential diagnostic and therapeutic targets for many diseases, including OSA. Here, we briefly review OSA pathophysiology and the technological advances in proteomics and the first results of its application to address critical issues in the OSA field.
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spelling Overview of proteomics studies in obstructive sleep apneaSleep ApneiaObstructive Sleep ApneaBiomarkersProteomicsMass SpectrometryLungMetabolic DisordersGenomica FuncionalGenómica Funcional e EstruturalObstructive sleep apnea (OSA) is an underdiagnosed common public health concern causing deleterious effects on metabolic and cardiovascular health. Although much has been learned regarding the pathophysiology and consequences of OSA in the past decades, the molecular mechanisms associated with such processes remain poorly defined. The advanced high-throughput proteomics-based technologies have become a fundamental approach for identifying novel disease mediators as potential diagnostic and therapeutic targets for many diseases, including OSA. Here, we briefly review OSA pathophysiology and the technological advances in proteomics and the first results of its application to address critical issues in the OSA field.Work partially supported by Harvard Medical School – Portugal Program (HMSP-ICJ/0022/2011), Fundação para a Ciência e a Tecnologia (FCT)/Poly-Annual Funding Program and FEDER/Saúde XXI Program (Portugal) and postdoctoral FCT-fellowship (SFRH/BPD/43365/2008).Elsevier/ World Association of Sleep Medicine and International Pediatric Sleep AssociationRepositório Científico do Instituto Nacional de SaúdeFeliciano, AméliaTorres, Vukosava M.Vaz, FatimaCarvalho, Ana SofiaMatthiesen, RunePinto, PaulaMalhotra, AtulBárbara, CristinaPenque, Deborah2015-06-26T16:48:31Z2015-042015-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/3093engSleep Med. 2015 Apr;16(4):437-45. doi: 10.1016/j.sleep.2014.11.014. Epub 2015 Feb 141389-945710.1016/j.sleep.2014.11.014info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:39:34Zoai:repositorio.insa.pt:10400.18/3093Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:37:58.211770Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Overview of proteomics studies in obstructive sleep apnea
title Overview of proteomics studies in obstructive sleep apnea
spellingShingle Overview of proteomics studies in obstructive sleep apnea
Feliciano, Amélia
Sleep Apneia
Obstructive Sleep Apnea
Biomarkers
Proteomics
Mass Spectrometry
Lung
Metabolic Disorders
Genomica Funcional
Genómica Funcional e Estrutural
title_short Overview of proteomics studies in obstructive sleep apnea
title_full Overview of proteomics studies in obstructive sleep apnea
title_fullStr Overview of proteomics studies in obstructive sleep apnea
title_full_unstemmed Overview of proteomics studies in obstructive sleep apnea
title_sort Overview of proteomics studies in obstructive sleep apnea
author Feliciano, Amélia
author_facet Feliciano, Amélia
Torres, Vukosava M.
Vaz, Fatima
Carvalho, Ana Sofia
Matthiesen, Rune
Pinto, Paula
Malhotra, Atul
Bárbara, Cristina
Penque, Deborah
author_role author
author2 Torres, Vukosava M.
Vaz, Fatima
Carvalho, Ana Sofia
Matthiesen, Rune
Pinto, Paula
Malhotra, Atul
Bárbara, Cristina
Penque, Deborah
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Feliciano, Amélia
Torres, Vukosava M.
Vaz, Fatima
Carvalho, Ana Sofia
Matthiesen, Rune
Pinto, Paula
Malhotra, Atul
Bárbara, Cristina
Penque, Deborah
dc.subject.por.fl_str_mv Sleep Apneia
Obstructive Sleep Apnea
Biomarkers
Proteomics
Mass Spectrometry
Lung
Metabolic Disorders
Genomica Funcional
Genómica Funcional e Estrutural
topic Sleep Apneia
Obstructive Sleep Apnea
Biomarkers
Proteomics
Mass Spectrometry
Lung
Metabolic Disorders
Genomica Funcional
Genómica Funcional e Estrutural
description Obstructive sleep apnea (OSA) is an underdiagnosed common public health concern causing deleterious effects on metabolic and cardiovascular health. Although much has been learned regarding the pathophysiology and consequences of OSA in the past decades, the molecular mechanisms associated with such processes remain poorly defined. The advanced high-throughput proteomics-based technologies have become a fundamental approach for identifying novel disease mediators as potential diagnostic and therapeutic targets for many diseases, including OSA. Here, we briefly review OSA pathophysiology and the technological advances in proteomics and the first results of its application to address critical issues in the OSA field.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-26T16:48:31Z
2015-04
2015-04-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/3093
url http://hdl.handle.net/10400.18/3093
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Sleep Med. 2015 Apr;16(4):437-45. doi: 10.1016/j.sleep.2014.11.014. Epub 2015 Feb 14
1389-9457
10.1016/j.sleep.2014.11.014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier/ World Association of Sleep Medicine and International Pediatric Sleep Association
publisher.none.fl_str_mv Elsevier/ World Association of Sleep Medicine and International Pediatric Sleep Association
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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