THE IMPACT OF DEFECTIVE HOST CELL GLYCOSYLATION IN BACTERIAL INFECTION

• Autor(a) principal: Mexia, Patrícia Alexandra Nunes
• Data de Publicação: 2023
• Tipo de documento: Dissertação
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10362/163207
• topic: Congenital Disorders of Glycosylation; PMM2-CDG; immune response; bacterial infection and adhesion

"Bacterial infections are a growing concern within medicine, in particular for vulnerable populations. This thesis delves with the crucial role of host glycans in host-pathogen interactions, that serve as beacon targets for tissue recognition and allow adhesion by pathogens, while functioning as sentinels, driving the host’s immune response. Congenital Disorders of Glycosylation are a group of rare diseases resulting from defects in cell glycosylation. PMM2-CDG, the most prevalent CDG, presents a deficit in N-glycosylation and is mainly known for its neurological involvement. Still, PMM2-CDG has almost 20% pediatric mortality associated with infection. Recent studies showed patients have higher propensity to respiratory, gastrointestinal, and severe infections in PMM2-CDG, but the affected immune mechanisms are still unknown.(...)"