Pinpointing cell identity in time and space

Detalhes bibliográficos
Autor(a) principal: Savulescu, Anca F.
Data de Publicação: 2020
Outros Autores: Jacobs, Caron, Negishi, Yutaka, Davignon, Laurianne, Mhlanga, Musa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/46301
Resumo: Copyright © 2020 Savulescu, Jacobs, Negishi, Davignon and Mhlanga. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Pinpointing cell identity in time and spaceSpatiotemporal localizationCell subtype classificationSpatial transcriptomicsMRNA subcellular localizationCell subtypeCopyright © 2020 Savulescu, Jacobs, Negishi, Davignon and Mhlanga. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Mammalian cells display a broad spectrum of phenotypes, morphologies, and functional niches within biological systems. Our understanding of mechanisms at the individual cellular level, and how cells function in concert to form tissues, organs and systems, has been greatly facilitated by centuries of extensive work to classify and characterize cell types. Classic histological approaches are now complemented with advanced single-cell sequencing and spatial transcriptomics for cell identity studies. Emerging data suggests that additional levels of information should be considered, including the subcellular spatial distribution of molecules such as RNA and protein, when classifying cells. In this Perspective piece we describe the importance of integrating cell transcriptional state with tissue and subcellular spatial and temporal information for thorough characterization of cell type and state. We refer to recent studies making use of single cell RNA-seq and/or image-based cell characterization, which highlight a need for such in-depth characterization of cell populations. We also describe the advances required in experimental, imaging and analytical methods to address these questions. This Perspective concludes by framing this argument in the context of projects such as the Human Cell Atlas, and related fields of cancer research and developmental biology.FrontiersRepositório da Universidade de LisboaSavulescu, Anca F.Jacobs, CaronNegishi, YutakaDavignon, LaurianneMhlanga, Musa2021-02-12T16:37:27Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46301engFront Mol Biosci. 2020 Aug 14;7:20910.3389/fmolb.2020.002092296-889Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:48:33Zoai:repositorio.ul.pt:10451/46301Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:58:32.176698Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Pinpointing cell identity in time and space
title Pinpointing cell identity in time and space
spellingShingle Pinpointing cell identity in time and space
Savulescu, Anca F.
Spatiotemporal localization
Cell subtype classification
Spatial transcriptomics
MRNA subcellular localization
Cell subtype
title_short Pinpointing cell identity in time and space
title_full Pinpointing cell identity in time and space
title_fullStr Pinpointing cell identity in time and space
title_full_unstemmed Pinpointing cell identity in time and space
title_sort Pinpointing cell identity in time and space
author Savulescu, Anca F.
author_facet Savulescu, Anca F.
Jacobs, Caron
Negishi, Yutaka
Davignon, Laurianne
Mhlanga, Musa
author_role author
author2 Jacobs, Caron
Negishi, Yutaka
Davignon, Laurianne
Mhlanga, Musa
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Savulescu, Anca F.
Jacobs, Caron
Negishi, Yutaka
Davignon, Laurianne
Mhlanga, Musa
dc.subject.por.fl_str_mv Spatiotemporal localization
Cell subtype classification
Spatial transcriptomics
MRNA subcellular localization
Cell subtype
topic Spatiotemporal localization
Cell subtype classification
Spatial transcriptomics
MRNA subcellular localization
Cell subtype
description Copyright © 2020 Savulescu, Jacobs, Negishi, Davignon and Mhlanga. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-02-12T16:37:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/46301
url http://hdl.handle.net/10451/46301
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Mol Biosci. 2020 Aug 14;7:209
10.3389/fmolb.2020.00209
2296-889X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
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instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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