Evaluation of double network hydrogel of poloxamer-heparin/gellan gum for bone marrow stem cells delivery carrier

Detalhes bibliográficos
Autor(a) principal: Choi, J. H.
Data de Publicação: 2019
Outros Autores: Choi, O. K., Lee, J., Noh, J., Lee, S., Park, A., Rim, M. A., Reis, R. L., Gilson, K.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/62605
Resumo: Supplementary material related to this article can be found, in the online version, at doi: https://doi.org/10.1016/j.colsurfb.2019.06.041.
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spelling Evaluation of double network hydrogel of poloxamer-heparin/gellan gum for bone marrow stem cells delivery carrierbone marrow stem cellsDouble network hydrogelhydrogelNature-derivedregenerationSyntheticScience & TechnologySupplementary material related to this article can be found, in the online version, at doi: https://doi.org/10.1016/j.colsurfb.2019.06.041.In this study, a double network hydrogel of a natural polysaccharide gellan gum (GG) hydrogel and a synthetic hydrogel poloxamer-heparin (PoH) hydrogel (PoH/GG DNH) is introduced to complement disadvantages of each hydrogel and improve the microenvironment for cell delivery. The microstructure, surface morphology, gelation temperature, swelling and weight loss, sol fraction, mechanical property and thermal stability was examined. The potential of the composite hydrogel for cell vehicle was demonstrated by encapsulation of bone marrow stem cells isolated from rabbits (rBMSCs) within the PoH/GG DNH in vitro. The results showed that the DNH system supported cell survival and retained rBMSCs morphology and phenotype. Moreover, cell distribution, adherence, and ECM production were supported by PoH/GG DNH in vivo. Overall results provide a potential opportunity to apply the composite hydrogels in tissue engineering purpose.This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI15C2996) and a grant of theKoreaHealthTechnology R&D Project through KHIDI (HI15C2996).ElsevierUniversidade do MinhoChoi, J. H.Choi, O. K.Lee, J.Noh, J.Lee, S.Park, A.Rim, M. A.Reis, R. L.Gilson, K.2019-062019-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/62605engChoi J. H., Choi O. K., Lee J., Noh J., Lee S., Park A., Rim M. A., Reis R. L., Gilson K. Evaluation of double network hydrogel of poloxamer-heparin/gellan gum for bone marrow stem cells delivery carrier, Colloids And Surfaces B : Biointerfaces, Vol. 181, pp. 879-889, doi:10.1016/j.colsurfb.2019.06.041, 20190927-776510.1016/j.colsurfb.2019.06.04131382336https://www.sciencedirect.com/science/article/pii/S0927776519304473info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:42:31Zoai:repositorium.sdum.uminho.pt:1822/62605Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:39:46.620667Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Evaluation of double network hydrogel of poloxamer-heparin/gellan gum for bone marrow stem cells delivery carrier
title Evaluation of double network hydrogel of poloxamer-heparin/gellan gum for bone marrow stem cells delivery carrier
spellingShingle Evaluation of double network hydrogel of poloxamer-heparin/gellan gum for bone marrow stem cells delivery carrier
Choi, J. H.
bone marrow stem cells
Double network hydrogel
hydrogel
Nature-derived
regeneration
Synthetic
Science & Technology
title_short Evaluation of double network hydrogel of poloxamer-heparin/gellan gum for bone marrow stem cells delivery carrier
title_full Evaluation of double network hydrogel of poloxamer-heparin/gellan gum for bone marrow stem cells delivery carrier
title_fullStr Evaluation of double network hydrogel of poloxamer-heparin/gellan gum for bone marrow stem cells delivery carrier
title_full_unstemmed Evaluation of double network hydrogel of poloxamer-heparin/gellan gum for bone marrow stem cells delivery carrier
title_sort Evaluation of double network hydrogel of poloxamer-heparin/gellan gum for bone marrow stem cells delivery carrier
author Choi, J. H.
author_facet Choi, J. H.
Choi, O. K.
Lee, J.
Noh, J.
Lee, S.
Park, A.
Rim, M. A.
Reis, R. L.
Gilson, K.
author_role author
author2 Choi, O. K.
Lee, J.
Noh, J.
Lee, S.
Park, A.
Rim, M. A.
Reis, R. L.
Gilson, K.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Choi, J. H.
Choi, O. K.
Lee, J.
Noh, J.
Lee, S.
Park, A.
Rim, M. A.
Reis, R. L.
Gilson, K.
dc.subject.por.fl_str_mv bone marrow stem cells
Double network hydrogel
hydrogel
Nature-derived
regeneration
Synthetic
Science & Technology
topic bone marrow stem cells
Double network hydrogel
hydrogel
Nature-derived
regeneration
Synthetic
Science & Technology
description Supplementary material related to this article can be found, in the online version, at doi: https://doi.org/10.1016/j.colsurfb.2019.06.041.
publishDate 2019
dc.date.none.fl_str_mv 2019-06
2019-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/62605
url http://hdl.handle.net/1822/62605
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Choi J. H., Choi O. K., Lee J., Noh J., Lee S., Park A., Rim M. A., Reis R. L., Gilson K. Evaluation of double network hydrogel of poloxamer-heparin/gellan gum for bone marrow stem cells delivery carrier, Colloids And Surfaces B : Biointerfaces, Vol. 181, pp. 879-889, doi:10.1016/j.colsurfb.2019.06.041, 2019
0927-7765
10.1016/j.colsurfb.2019.06.041
31382336
https://www.sciencedirect.com/science/article/pii/S0927776519304473
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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