Expression of DUSP4 transcript variants as a potential biomarker for colorectal cancer

Detalhes bibliográficos
Autor(a) principal: Varela, Tatiana
Data de Publicação: 2020
Outros Autores: Laizé, Vincent, Conceição, Natércia, Caldeira, Paulo, Marreiros, Ana, Guerreiro, Horacio, Cancela, M. Leonor
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/16460
Resumo: Aim: To provide novel data on the expression of DUSP4 transcripts in colorectal cancer (CRC) tissues and to explore their potential as biomarkers. Materials & methods:DUSP4 transcripts expression was determined by quantitative real-time PCR in tissues from 28 CRC patients. Their association with clinicopathological factors and survival analysis was performed. Data from 380 CRC patients available at The Cancer Genome Atlas project were also analyzed. Results: All transcripts were overexpressed in CRC tissues. Variant X1 was the most upregulated and associated with KRAS mutations and poorly differentiated tumor. Overexpression of DUSP4 transcripts could distinguish all tumor stages from normal tissues. Similar results were found in The Cancer Genome Atlas cohort. Conclusion:DUSP4 transcripts have the potential to serve as diagnostic biomarkers for CRC, particularly variant X1.
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spelling Expression of DUSP4 transcript variants as a potential biomarker for colorectal cancerBiomarkerColorectal cancerDUSP4Gene expressionTranscript variantsResearch & Experimental MedicineAim: To provide novel data on the expression of DUSP4 transcripts in colorectal cancer (CRC) tissues and to explore their potential as biomarkers. Materials & methods:DUSP4 transcripts expression was determined by quantitative real-time PCR in tissues from 28 CRC patients. Their association with clinicopathological factors and survival analysis was performed. Data from 380 CRC patients available at The Cancer Genome Atlas project were also analyzed. Results: All transcripts were overexpressed in CRC tissues. Variant X1 was the most upregulated and associated with KRAS mutations and poorly differentiated tumor. Overexpression of DUSP4 transcripts could distinguish all tumor stages from normal tissues. Similar results were found in The Cancer Genome Atlas cohort. Conclusion:DUSP4 transcripts have the potential to serve as diagnostic biomarkers for CRC, particularly variant X1.Portuguese Foundation for Science and Technology (FCT)Portuguese Foundation for Science and Technology [UIDB/04326/2020]Future Science GroupSapientiaVarela, TatianaLaizé, VincentConceição, NatérciaCaldeira, PauloMarreiros, AnaGuerreiro, HoracioCancela, M. Leonor2021-06-24T11:35:30Z2020-062020-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/16460eng1752-036310.2217/bmm-2019-0369info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:28:23Zoai:sapientia.ualg.pt:10400.1/16460Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:06:36.126385Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Expression of DUSP4 transcript variants as a potential biomarker for colorectal cancer
title Expression of DUSP4 transcript variants as a potential biomarker for colorectal cancer
spellingShingle Expression of DUSP4 transcript variants as a potential biomarker for colorectal cancer
Varela, Tatiana
Biomarker
Colorectal cancer
DUSP4
Gene expression
Transcript variants
Research & Experimental Medicine
title_short Expression of DUSP4 transcript variants as a potential biomarker for colorectal cancer
title_full Expression of DUSP4 transcript variants as a potential biomarker for colorectal cancer
title_fullStr Expression of DUSP4 transcript variants as a potential biomarker for colorectal cancer
title_full_unstemmed Expression of DUSP4 transcript variants as a potential biomarker for colorectal cancer
title_sort Expression of DUSP4 transcript variants as a potential biomarker for colorectal cancer
author Varela, Tatiana
author_facet Varela, Tatiana
Laizé, Vincent
Conceição, Natércia
Caldeira, Paulo
Marreiros, Ana
Guerreiro, Horacio
Cancela, M. Leonor
author_role author
author2 Laizé, Vincent
Conceição, Natércia
Caldeira, Paulo
Marreiros, Ana
Guerreiro, Horacio
Cancela, M. Leonor
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Sapientia
dc.contributor.author.fl_str_mv Varela, Tatiana
Laizé, Vincent
Conceição, Natércia
Caldeira, Paulo
Marreiros, Ana
Guerreiro, Horacio
Cancela, M. Leonor
dc.subject.por.fl_str_mv Biomarker
Colorectal cancer
DUSP4
Gene expression
Transcript variants
Research & Experimental Medicine
topic Biomarker
Colorectal cancer
DUSP4
Gene expression
Transcript variants
Research & Experimental Medicine
description Aim: To provide novel data on the expression of DUSP4 transcripts in colorectal cancer (CRC) tissues and to explore their potential as biomarkers. Materials & methods:DUSP4 transcripts expression was determined by quantitative real-time PCR in tissues from 28 CRC patients. Their association with clinicopathological factors and survival analysis was performed. Data from 380 CRC patients available at The Cancer Genome Atlas project were also analyzed. Results: All transcripts were overexpressed in CRC tissues. Variant X1 was the most upregulated and associated with KRAS mutations and poorly differentiated tumor. Overexpression of DUSP4 transcripts could distinguish all tumor stages from normal tissues. Similar results were found in The Cancer Genome Atlas cohort. Conclusion:DUSP4 transcripts have the potential to serve as diagnostic biomarkers for CRC, particularly variant X1.
publishDate 2020
dc.date.none.fl_str_mv 2020-06
2020-06-01T00:00:00Z
2021-06-24T11:35:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.1/16460
url http://hdl.handle.net/10400.1/16460
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1752-0363
10.2217/bmm-2019-0369
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Future Science Group
publisher.none.fl_str_mv Future Science Group
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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