Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish

• Autor(a) principal: Carneiro, Madalena C.
• Data de Publicação: 2016
• Outros Autores: Henriques, Catarina M., Nabais, Joana, Ferreira, Tânia, Carvalho, Tânia, Ferreira, Miguel Godinho
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.7/549
• topic: Telomeres; Zebrafish; Aging; Kidneys; Aging and cancer; Muscle analysis; Apoptosis; Muscle tissue

Telomeres shorten with each cell division and telomere dysfunction is a recognized hallmark of aging. Tissue proliferation is expected to dictate the rate at which telomeres shorten. We set out to test whether proliferative tissues age faster than non-proliferative due to telomere shortening during zebrafish aging. We performed a prospective study linking telomere length to tissue pathology and disease. Contrary to expectations, we show that telomeres shorten to critical lengths only in specific tissues and independently of their proliferation rate. Short telomeres accumulate in the gut but not in other highly proliferative tissues such as the blood and gonads. Notably, the muscle, a low proliferative tissue, accumulates short telomeres and DNA damage at the same rate as the gut. Together, our work shows that telomere shortening and DNA damage in key tissues triggers not only local dysfunction but also anticipates the onset of age-associated diseases in other tissues, including cancer.