Diastolic Dysfunction in Liver Cirrhosis: Prognostic Predictor in Liver Transplantation?
Main Author: | |
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Publication Date: | 2016 |
Other Authors: | , , , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Download full: | http://hdl.handle.net/10400.4/1866 |
Summary: | BACKGROUND: Patients with liver cirrhosis may develop cirrhotic cardiomyopathy (CC), characterized by blunted contractile responsiveness to stress, diastolic dysfunction (DD), and electrophysiological abnormalities. It may adversely affect the long-term prognosis of these patients. METHODS: We conducted a retrospective analysis of patients undergoing liver transplantation (LT) for cirrhosis from January 2012 to June 2015. We analyzed demographic characteristics, the etiology of cirrhosis, Child-Pugh and Model for End-Stage Liver Disease (MELD) scores, the corrected QT (QTc) interval in the preoperative period, diastolic and systolic dysfunction, mortality and survival, and duration of mechanical ventilation and vasopressor support in the post-LT period. These variables were compared with diastolic dysfunction and prolongation of QTc, with the use of chi-square, Fisher, and Mann-Whitney U tests. RESULTS: The study included 106 patients, 80.2% male and overall average age 54.83 years. The median MELD score was 16, and Child-Pugh class C in 55.4%. Prolonged QTc interval before LT was present in 19% and DD in 35.8% of patients. QTc before LT or DD did not vary significantly with MELD or Child-Pugh score. CONCLUSIONS: The patients in the pre-LT period presented with a significant incidence of DD, which can predispose them to adverse cardiac events. The presence of DD correlates with mortality after LT in patients with hepatic cirrhosis. |
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Diastolic Dysfunction in Liver Cirrhosis: Prognostic Predictor in Liver Transplantation?Cirrose HepáticaTransplantação de FígadoInsuficiência CardíacaBACKGROUND: Patients with liver cirrhosis may develop cirrhotic cardiomyopathy (CC), characterized by blunted contractile responsiveness to stress, diastolic dysfunction (DD), and electrophysiological abnormalities. It may adversely affect the long-term prognosis of these patients. METHODS: We conducted a retrospective analysis of patients undergoing liver transplantation (LT) for cirrhosis from January 2012 to June 2015. We analyzed demographic characteristics, the etiology of cirrhosis, Child-Pugh and Model for End-Stage Liver Disease (MELD) scores, the corrected QT (QTc) interval in the preoperative period, diastolic and systolic dysfunction, mortality and survival, and duration of mechanical ventilation and vasopressor support in the post-LT period. These variables were compared with diastolic dysfunction and prolongation of QTc, with the use of chi-square, Fisher, and Mann-Whitney U tests. RESULTS: The study included 106 patients, 80.2% male and overall average age 54.83 years. The median MELD score was 16, and Child-Pugh class C in 55.4%. Prolonged QTc interval before LT was present in 19% and DD in 35.8% of patients. QTc before LT or DD did not vary significantly with MELD or Child-Pugh score. CONCLUSIONS: The patients in the pre-LT period presented with a significant incidence of DD, which can predispose them to adverse cardiac events. The presence of DD correlates with mortality after LT in patients with hepatic cirrhosis.RIHUCCarvalheiro, FRodrigues, CAdrego, TViana, JSVieira, HSeco, CPereira, LPinto, FEufrásio, ABento, CFurtado, E2016-03-21T16:51:51Z20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.4/1866engTransplant Proc. 2016 Jan-Feb;48(1):128-31.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-11T14:23:09Zoai:rihuc.huc.min-saude.pt:10400.4/1866Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:04:18.949645Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Diastolic Dysfunction in Liver Cirrhosis: Prognostic Predictor in Liver Transplantation? |
title |
Diastolic Dysfunction in Liver Cirrhosis: Prognostic Predictor in Liver Transplantation? |
spellingShingle |
Diastolic Dysfunction in Liver Cirrhosis: Prognostic Predictor in Liver Transplantation? Carvalheiro, F Cirrose Hepática Transplantação de Fígado Insuficiência Cardíaca |
title_short |
Diastolic Dysfunction in Liver Cirrhosis: Prognostic Predictor in Liver Transplantation? |
title_full |
Diastolic Dysfunction in Liver Cirrhosis: Prognostic Predictor in Liver Transplantation? |
title_fullStr |
Diastolic Dysfunction in Liver Cirrhosis: Prognostic Predictor in Liver Transplantation? |
title_full_unstemmed |
Diastolic Dysfunction in Liver Cirrhosis: Prognostic Predictor in Liver Transplantation? |
title_sort |
Diastolic Dysfunction in Liver Cirrhosis: Prognostic Predictor in Liver Transplantation? |
author |
Carvalheiro, F |
author_facet |
Carvalheiro, F Rodrigues, C Adrego, T Viana, JS Vieira, H Seco, C Pereira, L Pinto, F Eufrásio, A Bento, C Furtado, E |
author_role |
author |
author2 |
Rodrigues, C Adrego, T Viana, JS Vieira, H Seco, C Pereira, L Pinto, F Eufrásio, A Bento, C Furtado, E |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
RIHUC |
dc.contributor.author.fl_str_mv |
Carvalheiro, F Rodrigues, C Adrego, T Viana, JS Vieira, H Seco, C Pereira, L Pinto, F Eufrásio, A Bento, C Furtado, E |
dc.subject.por.fl_str_mv |
Cirrose Hepática Transplantação de Fígado Insuficiência Cardíaca |
topic |
Cirrose Hepática Transplantação de Fígado Insuficiência Cardíaca |
description |
BACKGROUND: Patients with liver cirrhosis may develop cirrhotic cardiomyopathy (CC), characterized by blunted contractile responsiveness to stress, diastolic dysfunction (DD), and electrophysiological abnormalities. It may adversely affect the long-term prognosis of these patients. METHODS: We conducted a retrospective analysis of patients undergoing liver transplantation (LT) for cirrhosis from January 2012 to June 2015. We analyzed demographic characteristics, the etiology of cirrhosis, Child-Pugh and Model for End-Stage Liver Disease (MELD) scores, the corrected QT (QTc) interval in the preoperative period, diastolic and systolic dysfunction, mortality and survival, and duration of mechanical ventilation and vasopressor support in the post-LT period. These variables were compared with diastolic dysfunction and prolongation of QTc, with the use of chi-square, Fisher, and Mann-Whitney U tests. RESULTS: The study included 106 patients, 80.2% male and overall average age 54.83 years. The median MELD score was 16, and Child-Pugh class C in 55.4%. Prolonged QTc interval before LT was present in 19% and DD in 35.8% of patients. QTc before LT or DD did not vary significantly with MELD or Child-Pugh score. CONCLUSIONS: The patients in the pre-LT period presented with a significant incidence of DD, which can predispose them to adverse cardiac events. The presence of DD correlates with mortality after LT in patients with hepatic cirrhosis. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-03-21T16:51:51Z 2016 2016-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.4/1866 |
url |
http://hdl.handle.net/10400.4/1866 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Transplant Proc. 2016 Jan-Feb;48(1):128-31. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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