Diastolic Dysfunction in Liver Cirrhosis: Prognostic Predictor in Liver Transplantation?

Detalhes bibliográficos
Autor(a) principal: Carvalheiro, F
Data de Publicação: 2016
Outros Autores: Rodrigues, C, Adrego, T, Viana, JS, Vieira, H, Seco, C, Pereira, L, Pinto, F, Eufrásio, A, Bento, C, Furtado, E
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.4/1866
Resumo: BACKGROUND: Patients with liver cirrhosis may develop cirrhotic cardiomyopathy (CC), characterized by blunted contractile responsiveness to stress, diastolic dysfunction (DD), and electrophysiological abnormalities. It may adversely affect the long-term prognosis of these patients. METHODS: We conducted a retrospective analysis of patients undergoing liver transplantation (LT) for cirrhosis from January 2012 to June 2015. We analyzed demographic characteristics, the etiology of cirrhosis, Child-Pugh and Model for End-Stage Liver Disease (MELD) scores, the corrected QT (QTc) interval in the preoperative period, diastolic and systolic dysfunction, mortality and survival, and duration of mechanical ventilation and vasopressor support in the post-LT period. These variables were compared with diastolic dysfunction and prolongation of QTc, with the use of chi-square, Fisher, and Mann-Whitney U tests. RESULTS: The study included 106 patients, 80.2% male and overall average age 54.83 years. The median MELD score was 16, and Child-Pugh class C in 55.4%. Prolonged QTc interval before LT was present in 19% and DD in 35.8% of patients. QTc before LT or DD did not vary significantly with MELD or Child-Pugh score. CONCLUSIONS: The patients in the pre-LT period presented with a significant incidence of DD, which can predispose them to adverse cardiac events. The presence of DD correlates with mortality after LT in patients with hepatic cirrhosis.
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spelling Diastolic Dysfunction in Liver Cirrhosis: Prognostic Predictor in Liver Transplantation?Cirrose HepáticaTransplantação de FígadoInsuficiência CardíacaBACKGROUND: Patients with liver cirrhosis may develop cirrhotic cardiomyopathy (CC), characterized by blunted contractile responsiveness to stress, diastolic dysfunction (DD), and electrophysiological abnormalities. It may adversely affect the long-term prognosis of these patients. METHODS: We conducted a retrospective analysis of patients undergoing liver transplantation (LT) for cirrhosis from January 2012 to June 2015. We analyzed demographic characteristics, the etiology of cirrhosis, Child-Pugh and Model for End-Stage Liver Disease (MELD) scores, the corrected QT (QTc) interval in the preoperative period, diastolic and systolic dysfunction, mortality and survival, and duration of mechanical ventilation and vasopressor support in the post-LT period. These variables were compared with diastolic dysfunction and prolongation of QTc, with the use of chi-square, Fisher, and Mann-Whitney U tests. RESULTS: The study included 106 patients, 80.2% male and overall average age 54.83 years. The median MELD score was 16, and Child-Pugh class C in 55.4%. Prolonged QTc interval before LT was present in 19% and DD in 35.8% of patients. QTc before LT or DD did not vary significantly with MELD or Child-Pugh score. CONCLUSIONS: The patients in the pre-LT period presented with a significant incidence of DD, which can predispose them to adverse cardiac events. The presence of DD correlates with mortality after LT in patients with hepatic cirrhosis.RIHUCCarvalheiro, FRodrigues, CAdrego, TViana, JSVieira, HSeco, CPereira, LPinto, FEufrásio, ABento, CFurtado, E2016-03-21T16:51:51Z20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.4/1866engTransplant Proc. 2016 Jan-Feb;48(1):128-31.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-11T14:23:09Zoai:rihuc.huc.min-saude.pt:10400.4/1866Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:04:18.949645Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Diastolic Dysfunction in Liver Cirrhosis: Prognostic Predictor in Liver Transplantation?
title Diastolic Dysfunction in Liver Cirrhosis: Prognostic Predictor in Liver Transplantation?
spellingShingle Diastolic Dysfunction in Liver Cirrhosis: Prognostic Predictor in Liver Transplantation?
Carvalheiro, F
Cirrose Hepática
Transplantação de Fígado
Insuficiência Cardíaca
title_short Diastolic Dysfunction in Liver Cirrhosis: Prognostic Predictor in Liver Transplantation?
title_full Diastolic Dysfunction in Liver Cirrhosis: Prognostic Predictor in Liver Transplantation?
title_fullStr Diastolic Dysfunction in Liver Cirrhosis: Prognostic Predictor in Liver Transplantation?
title_full_unstemmed Diastolic Dysfunction in Liver Cirrhosis: Prognostic Predictor in Liver Transplantation?
title_sort Diastolic Dysfunction in Liver Cirrhosis: Prognostic Predictor in Liver Transplantation?
author Carvalheiro, F
author_facet Carvalheiro, F
Rodrigues, C
Adrego, T
Viana, JS
Vieira, H
Seco, C
Pereira, L
Pinto, F
Eufrásio, A
Bento, C
Furtado, E
author_role author
author2 Rodrigues, C
Adrego, T
Viana, JS
Vieira, H
Seco, C
Pereira, L
Pinto, F
Eufrásio, A
Bento, C
Furtado, E
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv RIHUC
dc.contributor.author.fl_str_mv Carvalheiro, F
Rodrigues, C
Adrego, T
Viana, JS
Vieira, H
Seco, C
Pereira, L
Pinto, F
Eufrásio, A
Bento, C
Furtado, E
dc.subject.por.fl_str_mv Cirrose Hepática
Transplantação de Fígado
Insuficiência Cardíaca
topic Cirrose Hepática
Transplantação de Fígado
Insuficiência Cardíaca
description BACKGROUND: Patients with liver cirrhosis may develop cirrhotic cardiomyopathy (CC), characterized by blunted contractile responsiveness to stress, diastolic dysfunction (DD), and electrophysiological abnormalities. It may adversely affect the long-term prognosis of these patients. METHODS: We conducted a retrospective analysis of patients undergoing liver transplantation (LT) for cirrhosis from January 2012 to June 2015. We analyzed demographic characteristics, the etiology of cirrhosis, Child-Pugh and Model for End-Stage Liver Disease (MELD) scores, the corrected QT (QTc) interval in the preoperative period, diastolic and systolic dysfunction, mortality and survival, and duration of mechanical ventilation and vasopressor support in the post-LT period. These variables were compared with diastolic dysfunction and prolongation of QTc, with the use of chi-square, Fisher, and Mann-Whitney U tests. RESULTS: The study included 106 patients, 80.2% male and overall average age 54.83 years. The median MELD score was 16, and Child-Pugh class C in 55.4%. Prolonged QTc interval before LT was present in 19% and DD in 35.8% of patients. QTc before LT or DD did not vary significantly with MELD or Child-Pugh score. CONCLUSIONS: The patients in the pre-LT period presented with a significant incidence of DD, which can predispose them to adverse cardiac events. The presence of DD correlates with mortality after LT in patients with hepatic cirrhosis.
publishDate 2016
dc.date.none.fl_str_mv 2016-03-21T16:51:51Z
2016
2016-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.4/1866
url http://hdl.handle.net/10400.4/1866
dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv Transplant Proc. 2016 Jan-Feb;48(1):128-31.
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