Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.16/2200 |
Resumo: | Inflammation is the driving force in inflammatory bowel disease (IBD) and its link to oxidative stress and carcinogenesis has long been accepted. The antioxidant system of the intestinal mucosa in IBD is compromised resulting in increased oxidative injury. This defective antioxidant system may be the result of genetic variants in antioxidant genes, which can represent susceptibility factors for IBD, namely Crohn's disease (CD) and ulcerative colitis (UC). Single nucleotide polymorphisms (SNPs) in the antioxidant genes SOD2 (rs4880) and GPX1 (rs1050450) were genotyped in a Portuguese population comprising 436 Crohn's disease and 367 ulcerative colitis patients, and 434 healthy controls. We found that the AA genotype in GPX1 is associated with ulcerative colitis (OR = 1.93, adjusted P-value = 0.037). Moreover, we found nominal significant associations between SOD2 and Crohn's disease susceptibility and disease subphenotypes but these did not withstand the correction for multiple testing. These findings indicate a possible link between disease phenotypes and antioxidant genes. These results suggest a potential role for antioxidant genes in IBD pathogenesis and should be considered in future association studies. |
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Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel DiseaseInflammation is the driving force in inflammatory bowel disease (IBD) and its link to oxidative stress and carcinogenesis has long been accepted. The antioxidant system of the intestinal mucosa in IBD is compromised resulting in increased oxidative injury. This defective antioxidant system may be the result of genetic variants in antioxidant genes, which can represent susceptibility factors for IBD, namely Crohn's disease (CD) and ulcerative colitis (UC). Single nucleotide polymorphisms (SNPs) in the antioxidant genes SOD2 (rs4880) and GPX1 (rs1050450) were genotyped in a Portuguese population comprising 436 Crohn's disease and 367 ulcerative colitis patients, and 434 healthy controls. We found that the AA genotype in GPX1 is associated with ulcerative colitis (OR = 1.93, adjusted P-value = 0.037). Moreover, we found nominal significant associations between SOD2 and Crohn's disease susceptibility and disease subphenotypes but these did not withstand the correction for multiple testing. These findings indicate a possible link between disease phenotypes and antioxidant genes. These results suggest a potential role for antioxidant genes in IBD pathogenesis and should be considered in future association studies.This work was supported by a grant from the Portuguese Study Group for Inflammatory Bowel Disease (GEDII) [http://www.gedii.pt/_bolsas_e_premios_a_decorrer]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscriptPublic Library of ScienceRepositório Científico do Centro Hospitalar Universitário de Santo AntónioCosta-Pereira, C.Durães, C.Coelho, R.Grácio, D.Silva, M.Peixoto, A.Lago, P.Pereira, M.Catarino, T.Pinho, S.Teixeira, J.Macedo, G.Annese, V.Magro, F.2018-07-05T14:28:43Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/2200engCosta Pereira C, Durães C, Coelho R, Grácio D, Silva M, Peixoto A, et al. (2017) Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease. PLoS ONE 12(1): e0169102. https://doi.org/10.1371/journal.pone.01691021932-620310.1371/journal.pone.0169102info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-20T10:59:31Zoai:repositorio.chporto.pt:10400.16/2200Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:38:25.622541Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease |
title |
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease |
spellingShingle |
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease Costa-Pereira, C. |
title_short |
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease |
title_full |
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease |
title_fullStr |
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease |
title_full_unstemmed |
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease |
title_sort |
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease |
author |
Costa-Pereira, C. |
author_facet |
Costa-Pereira, C. Durães, C. Coelho, R. Grácio, D. Silva, M. Peixoto, A. Lago, P. Pereira, M. Catarino, T. Pinho, S. Teixeira, J. Macedo, G. Annese, V. Magro, F. |
author_role |
author |
author2 |
Durães, C. Coelho, R. Grácio, D. Silva, M. Peixoto, A. Lago, P. Pereira, M. Catarino, T. Pinho, S. Teixeira, J. Macedo, G. Annese, V. Magro, F. |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Centro Hospitalar Universitário de Santo António |
dc.contributor.author.fl_str_mv |
Costa-Pereira, C. Durães, C. Coelho, R. Grácio, D. Silva, M. Peixoto, A. Lago, P. Pereira, M. Catarino, T. Pinho, S. Teixeira, J. Macedo, G. Annese, V. Magro, F. |
description |
Inflammation is the driving force in inflammatory bowel disease (IBD) and its link to oxidative stress and carcinogenesis has long been accepted. The antioxidant system of the intestinal mucosa in IBD is compromised resulting in increased oxidative injury. This defective antioxidant system may be the result of genetic variants in antioxidant genes, which can represent susceptibility factors for IBD, namely Crohn's disease (CD) and ulcerative colitis (UC). Single nucleotide polymorphisms (SNPs) in the antioxidant genes SOD2 (rs4880) and GPX1 (rs1050450) were genotyped in a Portuguese population comprising 436 Crohn's disease and 367 ulcerative colitis patients, and 434 healthy controls. We found that the AA genotype in GPX1 is associated with ulcerative colitis (OR = 1.93, adjusted P-value = 0.037). Moreover, we found nominal significant associations between SOD2 and Crohn's disease susceptibility and disease subphenotypes but these did not withstand the correction for multiple testing. These findings indicate a possible link between disease phenotypes and antioxidant genes. These results suggest a potential role for antioxidant genes in IBD pathogenesis and should be considered in future association studies. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z 2018-07-05T14:28:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.16/2200 |
url |
http://hdl.handle.net/10400.16/2200 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Costa Pereira C, Durães C, Coelho R, Grácio D, Silva M, Peixoto A, et al. (2017) Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease. PLoS ONE 12(1): e0169102. https://doi.org/10.1371/journal.pone.0169102 1932-6203 10.1371/journal.pone.0169102 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Public Library of Science |
publisher.none.fl_str_mv |
Public Library of Science |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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