Direct actions of adiponectin on changes in reproductive, metabolic, and anti-oxidative enzymes status in the testis of adult mice

Detalhes bibliográficos
Autor(a) principal: Choubey, Mayank
Data de Publicação: 2019
Outros Autores: Ranjan, Ashutosh, Bora, Puran S., Baltazar, Fátima, Krishna, Amitabh
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/58107
Resumo: Accepted manuscript
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spelling Direct actions of adiponectin on changes in reproductive, metabolic, and anti-oxidative enzymes status in the testis of adult miceAdiponectinInsulin receptorMetabolismOxidative stressSpermatogenesisTestisCiências Médicas::Medicina BásicaScience & TechnologyAccepted manuscriptObesity is a major health problem that is linked to decreased sperm count. It is hypothesized that an obesity-associated reduction in adiponectin secretion may be responsible for impairment of spermatogenesis. Therefore, the aim of the study was to evaluate the direct role of adiponectin in spermatogenesis and steroid synthesis in adult mice. This study showed that adiponectin receptors (AdipoR1 and AdipoR2) were localized in Leydig cells and seminiferous tubules in the testis of adult mice. The result of the in vitro study showed the direct action of adiponectin on spermatogenesis by stimulating cell proliferation (PCNA) and survival (Bcl2) and by suppressing cell apoptosis. Treatment of testis with adiponectin also enhanced transport of the energetic substrates glucose and lactate to protect cells from undergoing apoptosis. Adiponectin treatment further showed a significant reduction in oxidative stress and nitric oxide. Our findings suggest that adiponectin effectively facilitates cell survival and proliferation, as well as protects from apoptosis. Thus, adiponectin treatment may be responsible for enhancing sperm counts. Interestingly, this study showed the stimulatory effect of adiponectin in spermatogenesis but showed an inhibitory effect on testosterone and estradiol synthesis in the testes. Based on the present study, it is hypothesized that systemic adiponectin treatment may be a promising therapeutic strategy for the improvement of spermatogenesis and sperm count.University Grants Commission, New-Delhi, India. The authors would like to thank DeAnn Hubberd and Madison Hedrick from the Science Communications Department at the University of Arkansas for Medical Sciences for their work editing this manuscript. This work was also supported by Centre of Advanced Study, Department of Zoology, Banaras Hindu University, Varanasi, Indiainfo:eu-repo/semantics/acceptedVersionElsevierUniversidade do MinhoChoubey, MayankRanjan, AshutoshBora, Puran S.Baltazar, FátimaKrishna, Amitabh20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/58107engChoubey, M., Ranjan, A., Bora, P. S., Baltazar, F., & Krishna, A. (2018). Direct actions of adiponectin on changes in reproductive, metabolic, and anti-oxidative enzymes status in the testis of adult mice. General and comparative endocrinology0016-64801095-684010.1016/j.ygcen.2018.06.00229908833https://www.sciencedirect.com/science/article/pii/S001664801830203Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:23:06Zoai:repositorium.sdum.uminho.pt:1822/58107Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:16:44.637731Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Direct actions of adiponectin on changes in reproductive, metabolic, and anti-oxidative enzymes status in the testis of adult mice
title Direct actions of adiponectin on changes in reproductive, metabolic, and anti-oxidative enzymes status in the testis of adult mice
spellingShingle Direct actions of adiponectin on changes in reproductive, metabolic, and anti-oxidative enzymes status in the testis of adult mice
Choubey, Mayank
Adiponectin
Insulin receptor
Metabolism
Oxidative stress
Spermatogenesis
Testis
Ciências Médicas::Medicina Básica
Science & Technology
title_short Direct actions of adiponectin on changes in reproductive, metabolic, and anti-oxidative enzymes status in the testis of adult mice
title_full Direct actions of adiponectin on changes in reproductive, metabolic, and anti-oxidative enzymes status in the testis of adult mice
title_fullStr Direct actions of adiponectin on changes in reproductive, metabolic, and anti-oxidative enzymes status in the testis of adult mice
title_full_unstemmed Direct actions of adiponectin on changes in reproductive, metabolic, and anti-oxidative enzymes status in the testis of adult mice
title_sort Direct actions of adiponectin on changes in reproductive, metabolic, and anti-oxidative enzymes status in the testis of adult mice
author Choubey, Mayank
author_facet Choubey, Mayank
Ranjan, Ashutosh
Bora, Puran S.
Baltazar, Fátima
Krishna, Amitabh
author_role author
author2 Ranjan, Ashutosh
Bora, Puran S.
Baltazar, Fátima
Krishna, Amitabh
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Choubey, Mayank
Ranjan, Ashutosh
Bora, Puran S.
Baltazar, Fátima
Krishna, Amitabh
dc.subject.por.fl_str_mv Adiponectin
Insulin receptor
Metabolism
Oxidative stress
Spermatogenesis
Testis
Ciências Médicas::Medicina Básica
Science & Technology
topic Adiponectin
Insulin receptor
Metabolism
Oxidative stress
Spermatogenesis
Testis
Ciências Médicas::Medicina Básica
Science & Technology
description Accepted manuscript
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/58107
url http://hdl.handle.net/1822/58107
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Choubey, M., Ranjan, A., Bora, P. S., Baltazar, F., & Krishna, A. (2018). Direct actions of adiponectin on changes in reproductive, metabolic, and anti-oxidative enzymes status in the testis of adult mice. General and comparative endocrinology
0016-6480
1095-6840
10.1016/j.ygcen.2018.06.002
29908833
https://www.sciencedirect.com/science/article/pii/S001664801830203X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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