Long-Term Complications After Renal Transplantation

• Autor(a) principal: Martins, L.
• Data de Publicação: 2003
• Outros Autores: Ventura, A., Costa, S., Henriques, A., Dias, L., Sarmento, A.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.16/499

IN the past, every effort was directed at the prevention of acute rejection in renal transplant (RT) patients (pts). Ever since the introduction of the new immunosuppressive agents in the late 1990s, the short-term results of renal graft survival are considered satisfactory. In recent years, the prevention of long-term graft loss and the extension of life expectancy have gained new emphasis. The immunosuppressive agents though, namely calcineurin-inhibitors and steroids, may potentiate the development of several problems in RT pts: obesity, hyperglycemia, hyperlipidemia, and hypertension,1 which are not only risk factors for cardiovascular disease but also for graft loss.2,3 We performed a retrospective analysis of all RTs performed at our unit that reached 10 years (y) with a functioning graft. The aim of the study was to evaluate long-term complications and, in view of the results, to seek a possible strategy that minimizes these problems.