Severe Acute Hepatitis E in a Woman with an Autoimmune Background

Detalhes bibliográficos
Autor(a) principal: Nascimento, M
Data de Publicação: 2020
Outros Autores: Almeida-Santos, M, Fernandes, M, Maltez, F, Lino, S, Curran, M, Mesquita, J
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/3765
Resumo: Hepatitis E virus genotype 3 infections are normally asymptomatic in immunocompetent individuals. Symptomatic cases of acute icteric hepatitis E are seldom observed among women, younger men and children but are particularly seen in middle-aged/elderly men. We report a case of severe acute hepatitis E caused by genotype 3 in an immunocompetent 40-year-old woman that required prolonged hospitalization. Her medical history included an autoimmune background, namely atrophic gastritis and Graves' disease. She presented an extensive hepatic necrosis as revealed by the high levels of aminotransferases (ALT 4893 U/L; AST 3138 U/L). She showed also a coagulation disorder (prothrombin time; INR = 1.33). Serological markers for hepatitis viruses A, B and C were negative but serum was positive for hepatitis E virus RNA. Sequencing and phylogenetic analysis revealed that the hepatitis E virus strain belonged to subgenotype 3a. This is suggestive of an association between the severe acute hepatitis E virus genotype 3 infection and the autoimmune background.
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spelling Severe Acute Hepatitis E in a Woman with an Autoimmune BackgroundHepatite E Aguda Severa em Mulher com História Auto-ImuneAcute DiseaseAdultAutoimmune DiseasesFemaleHepatitis EHumansSeverity of Illness IndexHCC PAT CLINHCC INFHepatitis E virus genotype 3 infections are normally asymptomatic in immunocompetent individuals. Symptomatic cases of acute icteric hepatitis E are seldom observed among women, younger men and children but are particularly seen in middle-aged/elderly men. We report a case of severe acute hepatitis E caused by genotype 3 in an immunocompetent 40-year-old woman that required prolonged hospitalization. Her medical history included an autoimmune background, namely atrophic gastritis and Graves' disease. She presented an extensive hepatic necrosis as revealed by the high levels of aminotransferases (ALT 4893 U/L; AST 3138 U/L). She showed also a coagulation disorder (prothrombin time; INR = 1.33). Serological markers for hepatitis viruses A, B and C were negative but serum was positive for hepatitis E virus RNA. Sequencing and phylogenetic analysis revealed that the hepatitis E virus strain belonged to subgenotype 3a. This is suggestive of an association between the severe acute hepatitis E virus genotype 3 infection and the autoimmune background.Ordem dos MédicosRepositório do Centro Hospitalar Universitário de Lisboa Central, EPENascimento, MAlmeida-Santos, MFernandes, MMaltez, FLino, SCurran, MMesquita, J2021-07-15T14:28:49Z2020-06-012020-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/3765engActa Med Port. 2020 Jun 1;33(6):425-428.10.20344/amp.10429info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:44:14Zoai:repositorio.chlc.min-saude.pt:10400.17/3765Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:21:05.211437Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Severe Acute Hepatitis E in a Woman with an Autoimmune Background
Hepatite E Aguda Severa em Mulher com História Auto-Imune
title Severe Acute Hepatitis E in a Woman with an Autoimmune Background
spellingShingle Severe Acute Hepatitis E in a Woman with an Autoimmune Background
Nascimento, M
Acute Disease
Adult
Autoimmune Diseases
Female
Hepatitis E
Humans
Severity of Illness Index
HCC PAT CLIN
HCC INF
title_short Severe Acute Hepatitis E in a Woman with an Autoimmune Background
title_full Severe Acute Hepatitis E in a Woman with an Autoimmune Background
title_fullStr Severe Acute Hepatitis E in a Woman with an Autoimmune Background
title_full_unstemmed Severe Acute Hepatitis E in a Woman with an Autoimmune Background
title_sort Severe Acute Hepatitis E in a Woman with an Autoimmune Background
author Nascimento, M
author_facet Nascimento, M
Almeida-Santos, M
Fernandes, M
Maltez, F
Lino, S
Curran, M
Mesquita, J
author_role author
author2 Almeida-Santos, M
Fernandes, M
Maltez, F
Lino, S
Curran, M
Mesquita, J
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Nascimento, M
Almeida-Santos, M
Fernandes, M
Maltez, F
Lino, S
Curran, M
Mesquita, J
dc.subject.por.fl_str_mv Acute Disease
Adult
Autoimmune Diseases
Female
Hepatitis E
Humans
Severity of Illness Index
HCC PAT CLIN
HCC INF
topic Acute Disease
Adult
Autoimmune Diseases
Female
Hepatitis E
Humans
Severity of Illness Index
HCC PAT CLIN
HCC INF
description Hepatitis E virus genotype 3 infections are normally asymptomatic in immunocompetent individuals. Symptomatic cases of acute icteric hepatitis E are seldom observed among women, younger men and children but are particularly seen in middle-aged/elderly men. We report a case of severe acute hepatitis E caused by genotype 3 in an immunocompetent 40-year-old woman that required prolonged hospitalization. Her medical history included an autoimmune background, namely atrophic gastritis and Graves' disease. She presented an extensive hepatic necrosis as revealed by the high levels of aminotransferases (ALT 4893 U/L; AST 3138 U/L). She showed also a coagulation disorder (prothrombin time; INR = 1.33). Serological markers for hepatitis viruses A, B and C were negative but serum was positive for hepatitis E virus RNA. Sequencing and phylogenetic analysis revealed that the hepatitis E virus strain belonged to subgenotype 3a. This is suggestive of an association between the severe acute hepatitis E virus genotype 3 infection and the autoimmune background.
publishDate 2020
dc.date.none.fl_str_mv 2020-06-01
2020-06-01T00:00:00Z
2021-07-15T14:28:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/3765
url http://hdl.handle.net/10400.17/3765
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Med Port. 2020 Jun 1;33(6):425-428.
10.20344/amp.10429
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dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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