The diagnostic challenges of ovine pulmonary adenocarcinoma
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/27365 |
Resumo: | Ovine pulmonary adenocarcinoma (OPA), also known as sheep pulmonary adenomatosis and jaagsiekte, is a contagious pulmonary tumor of sheep, characterized by neoplastic proliferation of type II pneumocyte and club cells. OPA is induced by the oncogenic activity of the envelope glycoprotein (Env) of exogenous jaagsiekte sheep retrovirus (JSRV). This disease is associated with significant economic losses in numerous sheep raising countries. The onset of suggestive clinical signs is often late, making difficult the early diagnosis of the disease and timely implementation of control measures on the affected farms. Further, the lack of diagnostic tests that can be performed routinely by veterinary clinicians to accurately assess infected animals (e.g., serological or others) means that the true prevalence at flock level is not known. Imaging diagnostic methods (e.g., ultrasound, X-ray and computed tomography) can be used to support the clinical diagnosis, even in pre-clinical stages in affected flocks. The diagnosis must be confirmed by PCR of nasal excretions or immunohistochemistry and PCR of tumor lesions. No vaccine for OPA has yet been developed. Thus, in this work, we review the main methods of diagnosis of OPA in order to support the clinician in the identification of the disease, avoid underdiagnosis and allow the implementation of suitable measures to prevent and control its spread. |
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The diagnostic challenges of ovine pulmonary adenocarcinomaOvine pulmonary adenocarcinoma;Jaagsiekte sheep retrovirusPCRJistopathologyUltrasoundX-rayComputed tomographyResearch Subject Categories::VETERINARY MEDICINEOvine pulmonary adenocarcinoma (OPA), also known as sheep pulmonary adenomatosis and jaagsiekte, is a contagious pulmonary tumor of sheep, characterized by neoplastic proliferation of type II pneumocyte and club cells. OPA is induced by the oncogenic activity of the envelope glycoprotein (Env) of exogenous jaagsiekte sheep retrovirus (JSRV). This disease is associated with significant economic losses in numerous sheep raising countries. The onset of suggestive clinical signs is often late, making difficult the early diagnosis of the disease and timely implementation of control measures on the affected farms. Further, the lack of diagnostic tests that can be performed routinely by veterinary clinicians to accurately assess infected animals (e.g., serological or others) means that the true prevalence at flock level is not known. Imaging diagnostic methods (e.g., ultrasound, X-ray and computed tomography) can be used to support the clinical diagnosis, even in pre-clinical stages in affected flocks. The diagnosis must be confirmed by PCR of nasal excretions or immunohistochemistry and PCR of tumor lesions. No vaccine for OPA has yet been developed. Thus, in this work, we review the main methods of diagnosis of OPA in order to support the clinician in the identification of the disease, avoid underdiagnosis and allow the implementation of suitable measures to prevent and control its spread.This work was funded by 0687_OVISPID_2_E Interreg España-Portugal (EU) PoctepMDPIBiblioteca Digital do IPBQuintas, HelderPires, IsabelGarcês, AndreiaPrada, JustinaSilva, FilipeAlegria, Nuno2023-03-01T12:08:16Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/27365engQuintas, Helder; Pires, Isabel; Garcês, Andreia; Prada, Justina; Silva, Filipe; Alegria, Nuno (2021). The diagnostic challenges of ovine pulmonary adenocarcinoma. Ruminants. ISSN 2673-933X. 1, p. 58–712673-933X10.3390/ruminants1010005info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T11:01:22Zoai:bibliotecadigital.ipb.pt:10198/27365Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:18:00.782162Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The diagnostic challenges of ovine pulmonary adenocarcinoma |
title |
The diagnostic challenges of ovine pulmonary adenocarcinoma |
spellingShingle |
The diagnostic challenges of ovine pulmonary adenocarcinoma Quintas, Helder Ovine pulmonary adenocarcinoma; Jaagsiekte sheep retrovirus PCR Jistopathology Ultrasound X-ray Computed tomography Research Subject Categories::VETERINARY MEDICINE |
title_short |
The diagnostic challenges of ovine pulmonary adenocarcinoma |
title_full |
The diagnostic challenges of ovine pulmonary adenocarcinoma |
title_fullStr |
The diagnostic challenges of ovine pulmonary adenocarcinoma |
title_full_unstemmed |
The diagnostic challenges of ovine pulmonary adenocarcinoma |
title_sort |
The diagnostic challenges of ovine pulmonary adenocarcinoma |
author |
Quintas, Helder |
author_facet |
Quintas, Helder Pires, Isabel Garcês, Andreia Prada, Justina Silva, Filipe Alegria, Nuno |
author_role |
author |
author2 |
Pires, Isabel Garcês, Andreia Prada, Justina Silva, Filipe Alegria, Nuno |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Quintas, Helder Pires, Isabel Garcês, Andreia Prada, Justina Silva, Filipe Alegria, Nuno |
dc.subject.por.fl_str_mv |
Ovine pulmonary adenocarcinoma; Jaagsiekte sheep retrovirus PCR Jistopathology Ultrasound X-ray Computed tomography Research Subject Categories::VETERINARY MEDICINE |
topic |
Ovine pulmonary adenocarcinoma; Jaagsiekte sheep retrovirus PCR Jistopathology Ultrasound X-ray Computed tomography Research Subject Categories::VETERINARY MEDICINE |
description |
Ovine pulmonary adenocarcinoma (OPA), also known as sheep pulmonary adenomatosis and jaagsiekte, is a contagious pulmonary tumor of sheep, characterized by neoplastic proliferation of type II pneumocyte and club cells. OPA is induced by the oncogenic activity of the envelope glycoprotein (Env) of exogenous jaagsiekte sheep retrovirus (JSRV). This disease is associated with significant economic losses in numerous sheep raising countries. The onset of suggestive clinical signs is often late, making difficult the early diagnosis of the disease and timely implementation of control measures on the affected farms. Further, the lack of diagnostic tests that can be performed routinely by veterinary clinicians to accurately assess infected animals (e.g., serological or others) means that the true prevalence at flock level is not known. Imaging diagnostic methods (e.g., ultrasound, X-ray and computed tomography) can be used to support the clinical diagnosis, even in pre-clinical stages in affected flocks. The diagnosis must be confirmed by PCR of nasal excretions or immunohistochemistry and PCR of tumor lesions. No vaccine for OPA has yet been developed. Thus, in this work, we review the main methods of diagnosis of OPA in order to support the clinician in the identification of the disease, avoid underdiagnosis and allow the implementation of suitable measures to prevent and control its spread. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z 2023-03-01T12:08:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/27365 |
url |
http://hdl.handle.net/10198/27365 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Quintas, Helder; Pires, Isabel; Garcês, Andreia; Prada, Justina; Silva, Filipe; Alegria, Nuno (2021). The diagnostic challenges of ovine pulmonary adenocarcinoma. Ruminants. ISSN 2673-933X. 1, p. 58–71 2673-933X 10.3390/ruminants1010005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
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MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799135473076011008 |