Antifungal activity of a novel chromene dimer

Detalhes bibliográficos
Autor(a) principal: Abrunhosa, Luís
Data de Publicação: 2007
Outros Autores: Costa, M., Areias, F., Venâncio, Armando, Proença, M. Fernanda R. P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/7467
Resumo: The activity on Aspergillus spp. growth and on ochratoxin A production of two novel chromene dimers (3) was evaluated. The results of the bioassays indicate that the chromene dimer 3a inhibited mycelia growth by approximately 50% (EC50) at 140.1 μmol L−1 for A. niger, 384.2 μmol L−1 for A. carbonarius, 69.1 μmol L−1 for A. alliaceus and 559.1 μmol L−1 for A. ochraceus. When applied at concentrations of 2 mmol L−1, 3a totally inhibited the growth of all Aspergillus spp. tested. Furthermore, ochratoxin A production by A. alliaceus was reduced by about 94% with a 200 μmol L−1 solution of this compound. A moderate inhibitory effect was observed for the analogous structure 3b on ochratoxin A production but not in mycelia growth. No inhibition was registered for compounds 2a and 2b, used as synthetic precursors of the dimeric species 3.
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spelling Antifungal activity of a novel chromene dimerChromenesAspergillus spp.Ochratoxin AAntifungal compoundsScience & TechnologyThe activity on Aspergillus spp. growth and on ochratoxin A production of two novel chromene dimers (3) was evaluated. The results of the bioassays indicate that the chromene dimer 3a inhibited mycelia growth by approximately 50% (EC50) at 140.1 μmol L−1 for A. niger, 384.2 μmol L−1 for A. carbonarius, 69.1 μmol L−1 for A. alliaceus and 559.1 μmol L−1 for A. ochraceus. When applied at concentrations of 2 mmol L−1, 3a totally inhibited the growth of all Aspergillus spp. tested. Furthermore, ochratoxin A production by A. alliaceus was reduced by about 94% with a 200 μmol L−1 solution of this compound. A moderate inhibitory effect was observed for the analogous structure 3b on ochratoxin A production but not in mycelia growth. No inhibition was registered for compounds 2a and 2b, used as synthetic precursors of the dimeric species 3.Fundação para a Ciência e a Tecnologia (FCT) - SFRH/BD/11228/2002.Oxford University PressUniversidade do MinhoAbrunhosa, LuísCosta, M.Areias, F.Venâncio, ArmandoProença, M. Fernanda R. P.2007-122007-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/7467engL Abrunhosa, M Costa, F Areias, A Venâncio, F Proença, Antifungal activity of a novel chromene dimer, Journal of Industrial Microbiology and Biotechnology, Volume 34, Issue 12, 1 December 2007, Pages 787–792, https://doi.org/10.1007/s10295-007-0255-z1367-54351476-553510.1007/s10295-007-0255-z17899234https://academic.oup.com/jimb/article/34/12/787/5993107info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:47:28Zoai:repositorium.sdum.uminho.pt:1822/7467Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:45:34.261556Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Antifungal activity of a novel chromene dimer
title Antifungal activity of a novel chromene dimer
spellingShingle Antifungal activity of a novel chromene dimer
Abrunhosa, Luís
Chromenes
Aspergillus spp.
Ochratoxin A
Antifungal compounds
Science & Technology
title_short Antifungal activity of a novel chromene dimer
title_full Antifungal activity of a novel chromene dimer
title_fullStr Antifungal activity of a novel chromene dimer
title_full_unstemmed Antifungal activity of a novel chromene dimer
title_sort Antifungal activity of a novel chromene dimer
author Abrunhosa, Luís
author_facet Abrunhosa, Luís
Costa, M.
Areias, F.
Venâncio, Armando
Proença, M. Fernanda R. P.
author_role author
author2 Costa, M.
Areias, F.
Venâncio, Armando
Proença, M. Fernanda R. P.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Abrunhosa, Luís
Costa, M.
Areias, F.
Venâncio, Armando
Proença, M. Fernanda R. P.
dc.subject.por.fl_str_mv Chromenes
Aspergillus spp.
Ochratoxin A
Antifungal compounds
Science & Technology
topic Chromenes
Aspergillus spp.
Ochratoxin A
Antifungal compounds
Science & Technology
description The activity on Aspergillus spp. growth and on ochratoxin A production of two novel chromene dimers (3) was evaluated. The results of the bioassays indicate that the chromene dimer 3a inhibited mycelia growth by approximately 50% (EC50) at 140.1 μmol L−1 for A. niger, 384.2 μmol L−1 for A. carbonarius, 69.1 μmol L−1 for A. alliaceus and 559.1 μmol L−1 for A. ochraceus. When applied at concentrations of 2 mmol L−1, 3a totally inhibited the growth of all Aspergillus spp. tested. Furthermore, ochratoxin A production by A. alliaceus was reduced by about 94% with a 200 μmol L−1 solution of this compound. A moderate inhibitory effect was observed for the analogous structure 3b on ochratoxin A production but not in mycelia growth. No inhibition was registered for compounds 2a and 2b, used as synthetic precursors of the dimeric species 3.
publishDate 2007
dc.date.none.fl_str_mv 2007-12
2007-12-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/7467
url https://hdl.handle.net/1822/7467
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv L Abrunhosa, M Costa, F Areias, A Venâncio, F Proença, Antifungal activity of a novel chromene dimer, Journal of Industrial Microbiology and Biotechnology, Volume 34, Issue 12, 1 December 2007, Pages 787–792, https://doi.org/10.1007/s10295-007-0255-z
1367-5435
1476-5535
10.1007/s10295-007-0255-z
17899234
https://academic.oup.com/jimb/article/34/12/787/5993107
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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