Oxidative precipitation synthesis of calcium-doped manganese ferrite nanoparticles for magnetic hyperthermia

Detalhes bibliográficos
Autor(a) principal: Veloso, Sérgio Rafael Silva
Data de Publicação: 2022
Outros Autores: Andrade, Raquel G. D., Gomes, Valéria, Amorim, Carlos O., Amaral, Vítor S., Salgueiriño, Verónica, Coutinho, Paulo J. G., Ferreira, Paula M. T., Correa-Duarte, Miguel A., Castanheira, Elisabete M. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/80791
Resumo: Superparamagnetic nanoparticles are of high interest for therapeutic applications. In this work, nanoparticles of calcium-doped manganese ferrites (CaxMn1−xFe2O4) functionalized with citrate were synthesized through thermally assisted oxidative precipitation in aqueous media. The method provided well dispersed aqueous suspensions of nanoparticles through a one-pot synthesis, in which the temperature and Ca/Mn ratio were found to influence the particles microstructure and morphology. Consequently, changes were obtained in the optical and magnetic properties that were studied through UV-Vis absorption and SQUID, respectively. XRD and Raman spectroscopy studies were carried out to assess the microstructural changes associated with stoichiometry of the particles, and the stability in physiological pH was studied through DLS. The nanoparticles displayed high values of magnetization and heating efficiency for several alternating magnetic field conditions, compatible with biological applications. Hereby, the employed method provides a promising strategy for the development of particles with adequate properties for magnetic hyperthermia applications, such as drug delivery and cancer therapy.
id RCAP_dbe8231220213e5d56c7a23c412144f5
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/80791
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Oxidative precipitation synthesis of calcium-doped manganese ferrite nanoparticles for magnetic hyperthermiaMagnetic nanoparticlesSuperparamagnetismCitrate-stabilizationCalcium ferritesManganese ferritesMagnetic hyperthermiaCiências Naturais::Ciências FísicasEngenharia e Tecnologia::NanotecnologiaScience & TechnologySaúde de qualidadeSuperparamagnetic nanoparticles are of high interest for therapeutic applications. In this work, nanoparticles of calcium-doped manganese ferrites (CaxMn1−xFe2O4) functionalized with citrate were synthesized through thermally assisted oxidative precipitation in aqueous media. The method provided well dispersed aqueous suspensions of nanoparticles through a one-pot synthesis, in which the temperature and Ca/Mn ratio were found to influence the particles microstructure and morphology. Consequently, changes were obtained in the optical and magnetic properties that were studied through UV-Vis absorption and SQUID, respectively. XRD and Raman spectroscopy studies were carried out to assess the microstructural changes associated with stoichiometry of the particles, and the stability in physiological pH was studied through DLS. The nanoparticles displayed high values of magnetization and heating efficiency for several alternating magnetic field conditions, compatible with biological applications. Hereby, the employed method provides a promising strategy for the development of particles with adequate properties for magnetic hyperthermia applications, such as drug delivery and cancer therapy.This work was funded by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding of CF-UM-UP (UIDB/04650/2020, UIDP/04650/2020), CQUM (UIDB/00686/2020), CICECO Aveiro Institute of Materials (UIDB/50011/2020, UIDP/50011/2020 & LA/P/0006/2020) and by Ministerio de Economía y Competitividad de España (PID2020-113704RB-I00 and PID2020-119242RB-I00), Xunta de Galicia (Centro Singular de Investigación de Galicia—Accreditation 2019-2022 ED431G 2019/06 and IN607A 2018/5 and project ED431C 2020-06), and European Union (EU-ERDF Interreg V-A—Spain-Portugal 0245_IBEROS_1_E, 0712_ACUINANO_1_E, and 0624_2IQBIONEURO_6_E, and Interreg Atlantic Area NANOCULTURE 1.102.531), and the European Union H2020-MSCA-RISE-2019 PEPSA-MATE project. S.R.S. (872233) Veloso acknowledges FCT for a PhD grant (SFRH/BD/144017/2019). Support from MAP-Fis Doctoral Programme is also acknowledged.Multidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoVeloso, Sérgio Rafael SilvaAndrade, Raquel G. D.Gomes, ValériaAmorim, Carlos O.Amaral, Vítor S.Salgueiriño, VerónicaCoutinho, Paulo J. G.Ferreira, Paula M. T.Correa-Duarte, Miguel A.Castanheira, Elisabete M. S.2022-11-162022-11-16T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://hdl.handle.net/1822/80791engVeloso, S.R.S.; Andrade, R.G.D.; Gomes, V.; Amorim, C.O.; Amaral, V.S.; Salgueiriño, V.; Coutinho, P.J.G.; Ferreira, P.M.T.; Correa-Duarte, M.A.; Castanheira, E.M.S. Oxidative Precipitation Synthesis of Calcium-Doped Manganese Ferrite Nanoparticles for Magnetic Hyperthermia. Int. J. Mol. Sci. 2022, 23, 14145. https://doi.org/10.3390/ijms2322141451661-65961422-006710.3390/ijms232214145https://www.mdpi.com/1422-0067/23/22/14145info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:51:17Zoai:repositorium.sdum.uminho.pt:1822/80791Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:50:10.012071Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Oxidative precipitation synthesis of calcium-doped manganese ferrite nanoparticles for magnetic hyperthermia
title Oxidative precipitation synthesis of calcium-doped manganese ferrite nanoparticles for magnetic hyperthermia
spellingShingle Oxidative precipitation synthesis of calcium-doped manganese ferrite nanoparticles for magnetic hyperthermia
Veloso, Sérgio Rafael Silva
Magnetic nanoparticles
Superparamagnetism
Citrate-stabilization
Calcium ferrites
Manganese ferrites
Magnetic hyperthermia
Ciências Naturais::Ciências Físicas
Engenharia e Tecnologia::Nanotecnologia
Science & Technology
Saúde de qualidade
title_short Oxidative precipitation synthesis of calcium-doped manganese ferrite nanoparticles for magnetic hyperthermia
title_full Oxidative precipitation synthesis of calcium-doped manganese ferrite nanoparticles for magnetic hyperthermia
title_fullStr Oxidative precipitation synthesis of calcium-doped manganese ferrite nanoparticles for magnetic hyperthermia
title_full_unstemmed Oxidative precipitation synthesis of calcium-doped manganese ferrite nanoparticles for magnetic hyperthermia
title_sort Oxidative precipitation synthesis of calcium-doped manganese ferrite nanoparticles for magnetic hyperthermia
author Veloso, Sérgio Rafael Silva
author_facet Veloso, Sérgio Rafael Silva
Andrade, Raquel G. D.
Gomes, Valéria
Amorim, Carlos O.
Amaral, Vítor S.
Salgueiriño, Verónica
Coutinho, Paulo J. G.
Ferreira, Paula M. T.
Correa-Duarte, Miguel A.
Castanheira, Elisabete M. S.
author_role author
author2 Andrade, Raquel G. D.
Gomes, Valéria
Amorim, Carlos O.
Amaral, Vítor S.
Salgueiriño, Verónica
Coutinho, Paulo J. G.
Ferreira, Paula M. T.
Correa-Duarte, Miguel A.
Castanheira, Elisabete M. S.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Veloso, Sérgio Rafael Silva
Andrade, Raquel G. D.
Gomes, Valéria
Amorim, Carlos O.
Amaral, Vítor S.
Salgueiriño, Verónica
Coutinho, Paulo J. G.
Ferreira, Paula M. T.
Correa-Duarte, Miguel A.
Castanheira, Elisabete M. S.
dc.subject.por.fl_str_mv Magnetic nanoparticles
Superparamagnetism
Citrate-stabilization
Calcium ferrites
Manganese ferrites
Magnetic hyperthermia
Ciências Naturais::Ciências Físicas
Engenharia e Tecnologia::Nanotecnologia
Science & Technology
Saúde de qualidade
topic Magnetic nanoparticles
Superparamagnetism
Citrate-stabilization
Calcium ferrites
Manganese ferrites
Magnetic hyperthermia
Ciências Naturais::Ciências Físicas
Engenharia e Tecnologia::Nanotecnologia
Science & Technology
Saúde de qualidade
description Superparamagnetic nanoparticles are of high interest for therapeutic applications. In this work, nanoparticles of calcium-doped manganese ferrites (CaxMn1−xFe2O4) functionalized with citrate were synthesized through thermally assisted oxidative precipitation in aqueous media. The method provided well dispersed aqueous suspensions of nanoparticles through a one-pot synthesis, in which the temperature and Ca/Mn ratio were found to influence the particles microstructure and morphology. Consequently, changes were obtained in the optical and magnetic properties that were studied through UV-Vis absorption and SQUID, respectively. XRD and Raman spectroscopy studies were carried out to assess the microstructural changes associated with stoichiometry of the particles, and the stability in physiological pH was studied through DLS. The nanoparticles displayed high values of magnetization and heating efficiency for several alternating magnetic field conditions, compatible with biological applications. Hereby, the employed method provides a promising strategy for the development of particles with adequate properties for magnetic hyperthermia applications, such as drug delivery and cancer therapy.
publishDate 2022
dc.date.none.fl_str_mv 2022-11-16
2022-11-16T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/80791
url https://hdl.handle.net/1822/80791
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Veloso, S.R.S.; Andrade, R.G.D.; Gomes, V.; Amorim, C.O.; Amaral, V.S.; Salgueiriño, V.; Coutinho, P.J.G.; Ferreira, P.M.T.; Correa-Duarte, M.A.; Castanheira, E.M.S. Oxidative Precipitation Synthesis of Calcium-Doped Manganese Ferrite Nanoparticles for Magnetic Hyperthermia. Int. J. Mol. Sci. 2022, 23, 14145. https://doi.org/10.3390/ijms232214145
1661-6596
1422-0067
10.3390/ijms232214145
https://www.mdpi.com/1422-0067/23/22/14145
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799133085272375296

Registros relacionados