Excitotoxic lesions in the central nucleus of the amygdala attenuate stress-induced anxiety behavior
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/24225 |
Resumo: | The extended amygdala, composed by the amygdaloid nuclei and the bed nucleus of the stria terminalis (BNST), plays a critical role in anxiety behavior. In particular, the link between the central nucleus of the amygdala (CeA) and the BNST seems to be critical to the formation of anxiety-like behavior. Chronic unpredictable stress (CUS) exposure is recognized as a validated animal model of anxiety and is known to trigger significant morphofunctional changes in the extended amygdala. Quite surprisingly, no study has ever analyzed the role of the CeA in the onset of stress-induced anxiety and fear conditioning behaviors; thus, in the present study we induced a bilateral excitotoxic lesion in the CeA of rats that were subsequently exposed to a chronic stress protocol. Data shows that the lesion in the CeA induces different results in anxiety and fear-behaviors. More specifically, lesioned animals display attenuation of the stress response and of stress-induced anxiety-like behavior measured in the elevated-plus maze (EPM) when compared with stressed animals with sham lesions. This attenuation was paralleled by a decrease of stress-induced corticosterone levels. In contrast, we did not observe any significant effect of the lesion in the acoustic startle paradigm. As expected, lesion of the CeA precluded the appearance of fear behavior in a fear-potentiated startle paradigm in both non-stressed and stressed rats. These results confirm the implication of the CeA in fear conditioning behavior and unravel the relevance of this brain region in the regulation of the HPA axis activity and in the onset of anxiety behavior triggered by stress. |
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Excitotoxic lesions in the central nucleus of the amygdala attenuate stress-induced anxiety behaviorBNSTCentral amygdalaAnxietyExcitotoxic lesionExcitotoxic lesionsScience & TechnologyThe extended amygdala, composed by the amygdaloid nuclei and the bed nucleus of the stria terminalis (BNST), plays a critical role in anxiety behavior. In particular, the link between the central nucleus of the amygdala (CeA) and the BNST seems to be critical to the formation of anxiety-like behavior. Chronic unpredictable stress (CUS) exposure is recognized as a validated animal model of anxiety and is known to trigger significant morphofunctional changes in the extended amygdala. Quite surprisingly, no study has ever analyzed the role of the CeA in the onset of stress-induced anxiety and fear conditioning behaviors; thus, in the present study we induced a bilateral excitotoxic lesion in the CeA of rats that were subsequently exposed to a chronic stress protocol. Data shows that the lesion in the CeA induces different results in anxiety and fear-behaviors. More specifically, lesioned animals display attenuation of the stress response and of stress-induced anxiety-like behavior measured in the elevated-plus maze (EPM) when compared with stressed animals with sham lesions. This attenuation was paralleled by a decrease of stress-induced corticosterone levels. In contrast, we did not observe any significant effect of the lesion in the acoustic startle paradigm. As expected, lesion of the CeA precluded the appearance of fear behavior in a fear-potentiated startle paradigm in both non-stressed and stressed rats. These results confirm the implication of the CeA in fear conditioning behavior and unravel the relevance of this brain region in the regulation of the HPA axis activity and in the onset of anxiety behavior triggered by stress.Ana P. Ventura-Silva, Ana C. Ferreira, Miguel M. Carvalho and Filipa L. Campos were supported by Fundação para a Ciência e Tecnologia (FCT) grants.Frontiers MediaUniversidade do MinhoSilva, Ana Paula VenturaMelo, AntónioFerreira, Ana CatarinaCarvalho, M. M.Campos, Filipa L.Sousa, NunoPêgo, José M.2013-042013-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/24225engVentura-Silva AP, Melo A, Ferreira AC, Carvalho MM, Campos FL, Sousa N and Pêgo JM (2013) Excitotoxic lesions in the central nucleus of the amygdala attenuate stress-induced anxiety behavior. Front. Behav. Neurosci. 7:32. doi: 10.3389/fnbeh.2013.000321662-515310.3389/fnbeh.2013.00032http://dx.doi.org/10.3389/fnbeh.2013.00032info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:33:10Zoai:repositorium.sdum.uminho.pt:1822/24225Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:28:39.025640Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Excitotoxic lesions in the central nucleus of the amygdala attenuate stress-induced anxiety behavior |
title |
Excitotoxic lesions in the central nucleus of the amygdala attenuate stress-induced anxiety behavior |
spellingShingle |
Excitotoxic lesions in the central nucleus of the amygdala attenuate stress-induced anxiety behavior Silva, Ana Paula Ventura BNST Central amygdala Anxiety Excitotoxic lesion Excitotoxic lesions Science & Technology |
title_short |
Excitotoxic lesions in the central nucleus of the amygdala attenuate stress-induced anxiety behavior |
title_full |
Excitotoxic lesions in the central nucleus of the amygdala attenuate stress-induced anxiety behavior |
title_fullStr |
Excitotoxic lesions in the central nucleus of the amygdala attenuate stress-induced anxiety behavior |
title_full_unstemmed |
Excitotoxic lesions in the central nucleus of the amygdala attenuate stress-induced anxiety behavior |
title_sort |
Excitotoxic lesions in the central nucleus of the amygdala attenuate stress-induced anxiety behavior |
author |
Silva, Ana Paula Ventura |
author_facet |
Silva, Ana Paula Ventura Melo, António Ferreira, Ana Catarina Carvalho, M. M. Campos, Filipa L. Sousa, Nuno Pêgo, José M. |
author_role |
author |
author2 |
Melo, António Ferreira, Ana Catarina Carvalho, M. M. Campos, Filipa L. Sousa, Nuno Pêgo, José M. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Silva, Ana Paula Ventura Melo, António Ferreira, Ana Catarina Carvalho, M. M. Campos, Filipa L. Sousa, Nuno Pêgo, José M. |
dc.subject.por.fl_str_mv |
BNST Central amygdala Anxiety Excitotoxic lesion Excitotoxic lesions Science & Technology |
topic |
BNST Central amygdala Anxiety Excitotoxic lesion Excitotoxic lesions Science & Technology |
description |
The extended amygdala, composed by the amygdaloid nuclei and the bed nucleus of the stria terminalis (BNST), plays a critical role in anxiety behavior. In particular, the link between the central nucleus of the amygdala (CeA) and the BNST seems to be critical to the formation of anxiety-like behavior. Chronic unpredictable stress (CUS) exposure is recognized as a validated animal model of anxiety and is known to trigger significant morphofunctional changes in the extended amygdala. Quite surprisingly, no study has ever analyzed the role of the CeA in the onset of stress-induced anxiety and fear conditioning behaviors; thus, in the present study we induced a bilateral excitotoxic lesion in the CeA of rats that were subsequently exposed to a chronic stress protocol. Data shows that the lesion in the CeA induces different results in anxiety and fear-behaviors. More specifically, lesioned animals display attenuation of the stress response and of stress-induced anxiety-like behavior measured in the elevated-plus maze (EPM) when compared with stressed animals with sham lesions. This attenuation was paralleled by a decrease of stress-induced corticosterone levels. In contrast, we did not observe any significant effect of the lesion in the acoustic startle paradigm. As expected, lesion of the CeA precluded the appearance of fear behavior in a fear-potentiated startle paradigm in both non-stressed and stressed rats. These results confirm the implication of the CeA in fear conditioning behavior and unravel the relevance of this brain region in the regulation of the HPA axis activity and in the onset of anxiety behavior triggered by stress. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-04 2013-04-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/24225 |
url |
http://hdl.handle.net/1822/24225 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ventura-Silva AP, Melo A, Ferreira AC, Carvalho MM, Campos FL, Sousa N and Pêgo JM (2013) Excitotoxic lesions in the central nucleus of the amygdala attenuate stress-induced anxiety behavior. Front. Behav. Neurosci. 7:32. doi: 10.3389/fnbeh.2013.00032 1662-5153 10.3389/fnbeh.2013.00032 http://dx.doi.org/10.3389/fnbeh.2013.00032 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132783261515776 |