Defining the riddle in order to solve it: there is more than one “Parkinson's disease”
| Autor(a) principal: | |
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| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/57693 |
Resumo: | © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
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Defining the riddle in order to solve it: there is more than one “Parkinson's disease”Lewy bodyParkinson's diseaseBiological definitionBiomarkerDiagnostic criteriaNeurodegenerationNeuropathology© 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.Background: More than 200 years after James Parkinsondescribed a clinical syndrome based on his astute observations, Parkinson's disease (PD) has evolved into a complex entity, akin to the heterogeneity of other complex human syndromes of the central nervous system such as dementia, motor neuron disease, multiple sclerosis, and epilepsy. Clinicians, pathologists, and basic science researchers evolved arrange of concepts andcriteria for the clinical, genetic, mechanistic, and neuropathological characterization of what, in their best judgment, constitutes PD. However, these specialists have generated and used criteria that are not necessarily aligned between their different operational definitions, which may hinder progress in solving the riddle of the distinct forms of PD and ultimately how to treat them. Objective: This task force has identified current in consistencies between the definitions of PD and its diverse variants in different domains: clinical criteria, neuropathological classification, genetic subtyping, biomarker signatures, and mechanisms of disease. This initial effort for "defining the riddle" will lay the foundation for future attempts to better define the range of PD and its variants, as has been done and implemented for other heterogeneous neurological syndromes, such as stroke and peripheral neuropathy. We strongly advocate for a more systematic and evidence-based integration of our diverse disciplines by looking at well-defined variants of the syndrome of PD. Conclusion: Accuracy in defining endophenotypes of "typical PD" across these different but interrelated disciplines will enable better definition of variants and their stratification in therapeutic trials, a prerequisite for breakthroughs in the era of precision medicine. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.T.F.O. is supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy—EXC (2067/1-390729940). V.B. is supported by the Stichting Parkinson Fonds (the Netherlands). M.G.S. is supported by the Bhargava Family Research Chair in Neurodegeneration, the Department of Medicine at The Ottawa Hospital and its Foundation. B.M. is supported by The Michael J. Fox Foundation for PD Research, DFG, EU (Horizon 2020), the National Parkinson's Foundation, Parkinson Fonds Deutschland, and the Deutsche Parkinson Vereinigung. L.S. and T.F.O. were supported by IMPRiND and EU (Horizon 2020). H.S. was supported by the Advanced ERC program, The Michael J. Fox foundation, and the Israel Science Fund. We thank Dr. J.P. Vonsattel, Columbia University, for providing the images for Figure 2. Open Access funding enabled and organized by Projekt DEAL.WileyRepositório da Universidade de LisboaOuteiro, TiagoAlcalay, Roy N.Antonini, AngeloAttems, JohannesBonifati, VincenzoCardoso, FranciscoChesselet, Marie‐FrançoiseHardy, JohnMadeo, GraziellaMcKeith, IanMollenhauer, BritMoore, Darren J.Rascol, OlivierSchlossmacher, Michael G.Soreq, HermonaStefanis, LeonidasFerreira, Joaquim J2023-05-30T13:55:11Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/57693engMov Disord. 2023;10.1002/mds.294190885-318510.1002/mds.294191531-8257info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:06:28Zoai:repositorio.ul.pt:10451/57693Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:08:12.817887Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Defining the riddle in order to solve it: there is more than one “Parkinson's disease” |
| title |
Defining the riddle in order to solve it: there is more than one “Parkinson's disease” |
| spellingShingle |
Defining the riddle in order to solve it: there is more than one “Parkinson's disease” Outeiro, Tiago Lewy body Parkinson's disease Biological definition Biomarker Diagnostic criteria Neurodegeneration Neuropathology |
| title_short |
Defining the riddle in order to solve it: there is more than one “Parkinson's disease” |
| title_full |
Defining the riddle in order to solve it: there is more than one “Parkinson's disease” |
| title_fullStr |
Defining the riddle in order to solve it: there is more than one “Parkinson's disease” |
| title_full_unstemmed |
Defining the riddle in order to solve it: there is more than one “Parkinson's disease” |
| title_sort |
Defining the riddle in order to solve it: there is more than one “Parkinson's disease” |
| author |
Outeiro, Tiago |
| author_facet |
Outeiro, Tiago Alcalay, Roy N. Antonini, Angelo Attems, Johannes Bonifati, Vincenzo Cardoso, Francisco Chesselet, Marie‐Françoise Hardy, John Madeo, Graziella McKeith, Ian Mollenhauer, Brit Moore, Darren J. Rascol, Olivier Schlossmacher, Michael G. Soreq, Hermona Stefanis, Leonidas Ferreira, Joaquim J |
| author_role |
author |
| author2 |
Alcalay, Roy N. Antonini, Angelo Attems, Johannes Bonifati, Vincenzo Cardoso, Francisco Chesselet, Marie‐Françoise Hardy, John Madeo, Graziella McKeith, Ian Mollenhauer, Brit Moore, Darren J. Rascol, Olivier Schlossmacher, Michael G. Soreq, Hermona Stefanis, Leonidas Ferreira, Joaquim J |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Outeiro, Tiago Alcalay, Roy N. Antonini, Angelo Attems, Johannes Bonifati, Vincenzo Cardoso, Francisco Chesselet, Marie‐Françoise Hardy, John Madeo, Graziella McKeith, Ian Mollenhauer, Brit Moore, Darren J. Rascol, Olivier Schlossmacher, Michael G. Soreq, Hermona Stefanis, Leonidas Ferreira, Joaquim J |
| dc.subject.por.fl_str_mv |
Lewy body Parkinson's disease Biological definition Biomarker Diagnostic criteria Neurodegeneration Neuropathology |
| topic |
Lewy body Parkinson's disease Biological definition Biomarker Diagnostic criteria Neurodegeneration Neuropathology |
| description |
© 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
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2023 |
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2023-05-30T13:55:11Z 2023 2023-01-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/57693 |
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http://hdl.handle.net/10451/57693 |
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eng |
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eng |
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Mov Disord. 2023;10.1002/mds.29419 0885-3185 10.1002/mds.29419 1531-8257 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Wiley |
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Wiley |
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