Current progress on microRNAs-based therapeutics in neurodegenerative diseases

Detalhes bibliográficos
Autor(a) principal: Pereira, Patrícia
Data de Publicação: 2017
Outros Autores: Queiroz, João, Figueiras, Ana, Sousa, Fani
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/8176
Resumo: MicroRNAs (miRNAs)-based therapy has recently emerged as a promising strategy in the treatments of neurodegenerative diseases. Thus, in this review, the most recent and important challenges and advances on the development of miRNA therapeutics for brain targeting are discussed. In particular, this review highlights current knowledge and progress in the field of manufacturing, recovery, isolation, purification, and analysis of these therapeutic oligonucleotides. Finally, the available miRNA delivery systems are reviewed and an analysis is presented in what concerns to the current challenges that have to be addressed to ensure their specificity and efficacy. Overall, it is intended to provide a perspective on the future of miRNA-based therapeutics, focusing the biotechnological approach to obtain miRNAs. WIREs RNA 2017, 8:e1409. doi: 10.1002/wrna.1409 For further resources related to this article, please visit the WIREs website.
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spelling Current progress on microRNAs-based therapeutics in neurodegenerative diseasesAnimalsHumansMicroRNAsNeurodegenerative DiseasesGenetic TherapyMicroRNAs (miRNAs)-based therapy has recently emerged as a promising strategy in the treatments of neurodegenerative diseases. Thus, in this review, the most recent and important challenges and advances on the development of miRNA therapeutics for brain targeting are discussed. In particular, this review highlights current knowledge and progress in the field of manufacturing, recovery, isolation, purification, and analysis of these therapeutic oligonucleotides. Finally, the available miRNA delivery systems are reviewed and an analysis is presented in what concerns to the current challenges that have to be addressed to ensure their specificity and efficacy. Overall, it is intended to provide a perspective on the future of miRNA-based therapeutics, focusing the biotechnological approach to obtain miRNAs. WIREs RNA 2017, 8:e1409. doi: 10.1002/wrna.1409 For further resources related to this article, please visit the WIREs website.WileyuBibliorumPereira, PatríciaQueiroz, JoãoFigueiras, AnaSousa, Fani2020-01-09T16:19:25Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/8176eng10.1002/wrna.1409metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:47:58Zoai:ubibliorum.ubi.pt:10400.6/8176Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:48:34.202395Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Current progress on microRNAs-based therapeutics in neurodegenerative diseases
title Current progress on microRNAs-based therapeutics in neurodegenerative diseases
spellingShingle Current progress on microRNAs-based therapeutics in neurodegenerative diseases
Pereira, Patrícia
Animals
Humans
MicroRNAs
Neurodegenerative Diseases
Genetic Therapy
title_short Current progress on microRNAs-based therapeutics in neurodegenerative diseases
title_full Current progress on microRNAs-based therapeutics in neurodegenerative diseases
title_fullStr Current progress on microRNAs-based therapeutics in neurodegenerative diseases
title_full_unstemmed Current progress on microRNAs-based therapeutics in neurodegenerative diseases
title_sort Current progress on microRNAs-based therapeutics in neurodegenerative diseases
author Pereira, Patrícia
author_facet Pereira, Patrícia
Queiroz, João
Figueiras, Ana
Sousa, Fani
author_role author
author2 Queiroz, João
Figueiras, Ana
Sousa, Fani
author2_role author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Pereira, Patrícia
Queiroz, João
Figueiras, Ana
Sousa, Fani
dc.subject.por.fl_str_mv Animals
Humans
MicroRNAs
Neurodegenerative Diseases
Genetic Therapy
topic Animals
Humans
MicroRNAs
Neurodegenerative Diseases
Genetic Therapy
description MicroRNAs (miRNAs)-based therapy has recently emerged as a promising strategy in the treatments of neurodegenerative diseases. Thus, in this review, the most recent and important challenges and advances on the development of miRNA therapeutics for brain targeting are discussed. In particular, this review highlights current knowledge and progress in the field of manufacturing, recovery, isolation, purification, and analysis of these therapeutic oligonucleotides. Finally, the available miRNA delivery systems are reviewed and an analysis is presented in what concerns to the current challenges that have to be addressed to ensure their specificity and efficacy. Overall, it is intended to provide a perspective on the future of miRNA-based therapeutics, focusing the biotechnological approach to obtain miRNAs. WIREs RNA 2017, 8:e1409. doi: 10.1002/wrna.1409 For further resources related to this article, please visit the WIREs website.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
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