Cancer cell metabolism: Rewiring the mitochondrial hub
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/95483 https://doi.org/10.1016/j.bbadis.2020.166016 |
Resumo: | To adapt to tumoral environment conditions or even to escape chemotherapy, cells rapidly reprogram their metabolism to handle adversities and survive. Given the rapid rise of studies uncovering novel insights and therapeutic opportunities based on the role of mitochondria in tumor metabolic programing and therapeutics, this review summarizes most significant developments in the field. Taking in mind the key role of mitochondria on carcinogenesis and tumor progression due to their involvement on tumor plasticity, metabolic remodeling, and signaling re-wiring, those organelles are also potential therapeutic targets. Among other topics, we address the recent data intersecting mitochondria as of prognostic value and staging in cancer, by mitochondrial DNA (mtDNA) determination, and current inhibitors developments targeting mtDNA, OXPHOS machinery and metabolic pathways. We contribute for a holistic view of the role of mitochondria metabolism and directed therapeutics to understand tumor metabolism, to circumvent therapy resistance, and to control tumor development. |
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Cancer cell metabolism: Rewiring the mitochondrial hubCancerMetabolic pathwaysMetabolismMitochondriamtDNAAntineoplastic AgentsDNA, MitochondrialDrug Resistance, NeoplasmHumansMitochondriaNeoplasm StagingNeoplasmsOxidative PhosphorylationPrognosisSignal TransductionTumor MicroenvironmentWarburg Effect, OncologicTo adapt to tumoral environment conditions or even to escape chemotherapy, cells rapidly reprogram their metabolism to handle adversities and survive. Given the rapid rise of studies uncovering novel insights and therapeutic opportunities based on the role of mitochondria in tumor metabolic programing and therapeutics, this review summarizes most significant developments in the field. Taking in mind the key role of mitochondria on carcinogenesis and tumor progression due to their involvement on tumor plasticity, metabolic remodeling, and signaling re-wiring, those organelles are also potential therapeutic targets. Among other topics, we address the recent data intersecting mitochondria as of prognostic value and staging in cancer, by mitochondrial DNA (mtDNA) determination, and current inhibitors developments targeting mtDNA, OXPHOS machinery and metabolic pathways. We contribute for a holistic view of the role of mitochondria metabolism and directed therapeutics to understand tumor metabolism, to circumvent therapy resistance, and to control tumor development.Gabriela L. Oliveira is supported by project “Summer Course in Interdisciplinary Research, Development and Innovation in Cellular and Molecular Metabolism” (15-20/7/245), funded by FCT and Directorate General for Higher Education (DGES).2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/95483http://hdl.handle.net/10316/95483https://doi.org/10.1016/j.bbadis.2020.166016eng09254439https://www.sciencedirect.com/science/article/pii/S0925443920303641Oliveira, Gabriela L.Coelho, Ana R.Marques, RicardoOliveira, Paulo J.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-25T04:24:58Zoai:estudogeral.uc.pt:10316/95483Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:13:58.197958Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Cancer cell metabolism: Rewiring the mitochondrial hub |
title |
Cancer cell metabolism: Rewiring the mitochondrial hub |
spellingShingle |
Cancer cell metabolism: Rewiring the mitochondrial hub Oliveira, Gabriela L. Cancer Metabolic pathways Metabolism Mitochondria mtDNA Antineoplastic Agents DNA, Mitochondrial Drug Resistance, Neoplasm Humans Mitochondria Neoplasm Staging Neoplasms Oxidative Phosphorylation Prognosis Signal Transduction Tumor Microenvironment Warburg Effect, Oncologic |
title_short |
Cancer cell metabolism: Rewiring the mitochondrial hub |
title_full |
Cancer cell metabolism: Rewiring the mitochondrial hub |
title_fullStr |
Cancer cell metabolism: Rewiring the mitochondrial hub |
title_full_unstemmed |
Cancer cell metabolism: Rewiring the mitochondrial hub |
title_sort |
Cancer cell metabolism: Rewiring the mitochondrial hub |
author |
Oliveira, Gabriela L. |
author_facet |
Oliveira, Gabriela L. Coelho, Ana R. Marques, Ricardo Oliveira, Paulo J. |
author_role |
author |
author2 |
Coelho, Ana R. Marques, Ricardo Oliveira, Paulo J. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Gabriela L. Coelho, Ana R. Marques, Ricardo Oliveira, Paulo J. |
dc.subject.por.fl_str_mv |
Cancer Metabolic pathways Metabolism Mitochondria mtDNA Antineoplastic Agents DNA, Mitochondrial Drug Resistance, Neoplasm Humans Mitochondria Neoplasm Staging Neoplasms Oxidative Phosphorylation Prognosis Signal Transduction Tumor Microenvironment Warburg Effect, Oncologic |
topic |
Cancer Metabolic pathways Metabolism Mitochondria mtDNA Antineoplastic Agents DNA, Mitochondrial Drug Resistance, Neoplasm Humans Mitochondria Neoplasm Staging Neoplasms Oxidative Phosphorylation Prognosis Signal Transduction Tumor Microenvironment Warburg Effect, Oncologic |
description |
To adapt to tumoral environment conditions or even to escape chemotherapy, cells rapidly reprogram their metabolism to handle adversities and survive. Given the rapid rise of studies uncovering novel insights and therapeutic opportunities based on the role of mitochondria in tumor metabolic programing and therapeutics, this review summarizes most significant developments in the field. Taking in mind the key role of mitochondria on carcinogenesis and tumor progression due to their involvement on tumor plasticity, metabolic remodeling, and signaling re-wiring, those organelles are also potential therapeutic targets. Among other topics, we address the recent data intersecting mitochondria as of prognostic value and staging in cancer, by mitochondrial DNA (mtDNA) determination, and current inhibitors developments targeting mtDNA, OXPHOS machinery and metabolic pathways. We contribute for a holistic view of the role of mitochondria metabolism and directed therapeutics to understand tumor metabolism, to circumvent therapy resistance, and to control tumor development. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/95483 http://hdl.handle.net/10316/95483 https://doi.org/10.1016/j.bbadis.2020.166016 |
url |
http://hdl.handle.net/10316/95483 https://doi.org/10.1016/j.bbadis.2020.166016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
09254439 https://www.sciencedirect.com/science/article/pii/S0925443920303641 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134036826783744 |