Real-World Characterization of the Portuguese Population Living with HIV who Initiated Raltegravir Based-Regimens: The REALITY Study
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16785 |
Resumo: | Introduction: Although raltegravir has been available since 2007, data are lacking on the Portuguese population living with HIV who initiated this antiretroviral therapy. Hence, this study aimed to characterize the patients who initiated raltegravir-based regimens between January 2015 and December 2017, on sociodemographics, clinical features, and treatment satisfaction.Material and Methods: Observational, retrospective, multicentre study conducted at 11 reference sites. Sociodemographic and clinical data were collected retrospectively from hospital medical records. For participants continuing raltegravir at study inclusion, the HIV Treatment Satisfaction Questionnaire was administered to assess satisfaction with raltegravir-based therapy. Descriptive statistics were performed. Treatment-naïve and treatment-experienced subgroups were compared for demographic and clinical variables.Results: A total of 302 patients were included; mostly men (69.5%) with a mean age of 49 years old. Approximately half of the patients had at least one non-AIDS-related comorbidity at baseline (53.3%), such as hypercholesterolemia, arterial hypertension, diabetes mellitus, and depression. Moreover, 52.3% were treatment-experienced patients with up to two treatments prior to raltegravir. Across the study time points, there was a reduction in the viral load and improvement in CD4 counts in both the treatment-naïve and treatment-experienced subgroups. Continuing users of raltegravir reported high treatment satisfaction (55.4 ± 7.2 points).Conclusion: Raltegravir-based regimens seem like a valid therapeutic option in heterogeneous populations of HIV-infected patients, in patients with previous ART experience and as part of first-line therapeutic options alongside with the latest generation of drugs from its class. |
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Real-World Characterization of the Portuguese Population Living with HIV who Initiated Raltegravir Based-Regimens: The REALITY StudyCaracterização da População Portuguesa com VIH que Iniciou um Regime Baseado em Raltegravir: O Estudo REALITYAnti-Retroviral AgentsHIV Infections/complicationsHIV Infections/drug therapyPortugalRaltegravir Potassium/therapeutic useAntirretroviraisInfecções por VIH/complicaçõesInfecções por VIH/tratamento farmacológicoPortugalRaltegravir Potássico/uso terapêuticoIntroduction: Although raltegravir has been available since 2007, data are lacking on the Portuguese population living with HIV who initiated this antiretroviral therapy. Hence, this study aimed to characterize the patients who initiated raltegravir-based regimens between January 2015 and December 2017, on sociodemographics, clinical features, and treatment satisfaction.Material and Methods: Observational, retrospective, multicentre study conducted at 11 reference sites. Sociodemographic and clinical data were collected retrospectively from hospital medical records. For participants continuing raltegravir at study inclusion, the HIV Treatment Satisfaction Questionnaire was administered to assess satisfaction with raltegravir-based therapy. Descriptive statistics were performed. Treatment-naïve and treatment-experienced subgroups were compared for demographic and clinical variables.Results: A total of 302 patients were included; mostly men (69.5%) with a mean age of 49 years old. Approximately half of the patients had at least one non-AIDS-related comorbidity at baseline (53.3%), such as hypercholesterolemia, arterial hypertension, diabetes mellitus, and depression. Moreover, 52.3% were treatment-experienced patients with up to two treatments prior to raltegravir. Across the study time points, there was a reduction in the viral load and improvement in CD4 counts in both the treatment-naïve and treatment-experienced subgroups. Continuing users of raltegravir reported high treatment satisfaction (55.4 ± 7.2 points).Conclusion: Raltegravir-based regimens seem like a valid therapeutic option in heterogeneous populations of HIV-infected patients, in patients with previous ART experience and as part of first-line therapeutic options alongside with the latest generation of drugs from its class.Introdução: Apesar de o raltegravir estar disponível desde 2007, os dados na população portuguesa com VIH que iniciou esta terapêutica antirretroviral são escassos. Deste modo, este estudo teve por objetivo caracterizar os doentes que iniciaram um regime terapêutico baseado em raltegravir entre janeiro de 2015 e dezembro de 2017, relativamente a dados sociodemográficos, características clínicas e satisfação com o tratamento.Material e Métodos: Estudo observacional, retrospetivo, multicêntrico conduzido em 11 centros de referência. Os dados sociodemográficos e clínicos foram recolhidos retrospetivamente nos processos clínicos. Os participantes que continuaram o regime com raltegravir após a inclusão no estudo preencheram o HIV Treatment Satisfaction Questionnaire para avaliar a satisfação com a terapêutica. Foram efetuadas análises de estatística descritiva e comparações para as variáveis sociodemográficas e clínicas nos subgrupos de doentes naïve de tratamento e de doentes com experiência terapêutica.Resultados: Foram incluídos 302 doentes, maioritariamente do sexo masculino (69,5%) com idade média de 49 anos. Aproximadamente metade dos doentes tinha pelo menos uma comorbilidade não relacionada com SIDA no início do estudo (53,3%), tais como hipercolesterolemia, hipertensão arterial, diabetes mellitus ou depressão. Adicionalmente, 52,3% eram doentes com experiência terapêutica com até dois tratamentos anteriores ao raltegravir. Ao longo do estudo verificou-se uma redução na carga viral e uma melhoria nas contagens de CD4 em ambos os subgrupos de doentes (doentes naïve de tratamento e doentes com experiência terapêutica). Os doentes com uso continuado de raltegravir reportaram uma elevada satisfação com o tratamento (55,4 ± 7,2 pontos).Conclusão: Os regimes terapêuticos baseados em raltegravir parecem ser uma opção terapêutica válida em populações heterogéneas de doentes infetados com VIH, em doentes com experiência em ART e como tratamento de primeira linha, em paralelo com outras terapêuticas de última geração.Ordem dos Médicos2022-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16785oai:ojs.www.actamedicaportuguesa.com:article/16785Acta Médica Portuguesa; Vol. 35 No. 7-8 (2022): July-August; 529-539Acta Médica Portuguesa; Vol. 35 N.º 7-8 (2022): Julho-Agosto; 529-5391646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16785https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16785/6594https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16785/6595Direitos de Autor (c) 2022 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessSerrão, RosárioMansinho, KamalMaltez, FernandoMarques, NunoCarvalho, AlexandrePazos, RosárioZagalo, AlexandraMendez, JosefinaNeves, IsabelOliveira, JoaquimPacheco, PatríciaCorreia de Abreu, RicardoMiranda, Ana CláudiaCamacho, PaulaPaixão, LauraAlmeida, Joana2022-12-20T11:07:56Zoai:ojs.www.actamedicaportuguesa.com:article/16785Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:20:49.713893Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Real-World Characterization of the Portuguese Population Living with HIV who Initiated Raltegravir Based-Regimens: The REALITY Study Caracterização da População Portuguesa com VIH que Iniciou um Regime Baseado em Raltegravir: O Estudo REALITY |
title |
Real-World Characterization of the Portuguese Population Living with HIV who Initiated Raltegravir Based-Regimens: The REALITY Study |
spellingShingle |
Real-World Characterization of the Portuguese Population Living with HIV who Initiated Raltegravir Based-Regimens: The REALITY Study Serrão, Rosário Anti-Retroviral Agents HIV Infections/complications HIV Infections/drug therapy Portugal Raltegravir Potassium/therapeutic use Antirretrovirais Infecções por VIH/complicações Infecções por VIH/tratamento farmacológico Portugal Raltegravir Potássico/uso terapêutico |
title_short |
Real-World Characterization of the Portuguese Population Living with HIV who Initiated Raltegravir Based-Regimens: The REALITY Study |
title_full |
Real-World Characterization of the Portuguese Population Living with HIV who Initiated Raltegravir Based-Regimens: The REALITY Study |
title_fullStr |
Real-World Characterization of the Portuguese Population Living with HIV who Initiated Raltegravir Based-Regimens: The REALITY Study |
title_full_unstemmed |
Real-World Characterization of the Portuguese Population Living with HIV who Initiated Raltegravir Based-Regimens: The REALITY Study |
title_sort |
Real-World Characterization of the Portuguese Population Living with HIV who Initiated Raltegravir Based-Regimens: The REALITY Study |
author |
Serrão, Rosário |
author_facet |
Serrão, Rosário Mansinho, Kamal Maltez, Fernando Marques, Nuno Carvalho, Alexandre Pazos, Rosário Zagalo, Alexandra Mendez, Josefina Neves, Isabel Oliveira, Joaquim Pacheco, Patrícia Correia de Abreu, Ricardo Miranda, Ana Cláudia Camacho, Paula Paixão, Laura Almeida, Joana |
author_role |
author |
author2 |
Mansinho, Kamal Maltez, Fernando Marques, Nuno Carvalho, Alexandre Pazos, Rosário Zagalo, Alexandra Mendez, Josefina Neves, Isabel Oliveira, Joaquim Pacheco, Patrícia Correia de Abreu, Ricardo Miranda, Ana Cláudia Camacho, Paula Paixão, Laura Almeida, Joana |
author2_role |
author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Serrão, Rosário Mansinho, Kamal Maltez, Fernando Marques, Nuno Carvalho, Alexandre Pazos, Rosário Zagalo, Alexandra Mendez, Josefina Neves, Isabel Oliveira, Joaquim Pacheco, Patrícia Correia de Abreu, Ricardo Miranda, Ana Cláudia Camacho, Paula Paixão, Laura Almeida, Joana |
dc.subject.por.fl_str_mv |
Anti-Retroviral Agents HIV Infections/complications HIV Infections/drug therapy Portugal Raltegravir Potassium/therapeutic use Antirretrovirais Infecções por VIH/complicações Infecções por VIH/tratamento farmacológico Portugal Raltegravir Potássico/uso terapêutico |
topic |
Anti-Retroviral Agents HIV Infections/complications HIV Infections/drug therapy Portugal Raltegravir Potassium/therapeutic use Antirretrovirais Infecções por VIH/complicações Infecções por VIH/tratamento farmacológico Portugal Raltegravir Potássico/uso terapêutico |
description |
Introduction: Although raltegravir has been available since 2007, data are lacking on the Portuguese population living with HIV who initiated this antiretroviral therapy. Hence, this study aimed to characterize the patients who initiated raltegravir-based regimens between January 2015 and December 2017, on sociodemographics, clinical features, and treatment satisfaction.Material and Methods: Observational, retrospective, multicentre study conducted at 11 reference sites. Sociodemographic and clinical data were collected retrospectively from hospital medical records. For participants continuing raltegravir at study inclusion, the HIV Treatment Satisfaction Questionnaire was administered to assess satisfaction with raltegravir-based therapy. Descriptive statistics were performed. Treatment-naïve and treatment-experienced subgroups were compared for demographic and clinical variables.Results: A total of 302 patients were included; mostly men (69.5%) with a mean age of 49 years old. Approximately half of the patients had at least one non-AIDS-related comorbidity at baseline (53.3%), such as hypercholesterolemia, arterial hypertension, diabetes mellitus, and depression. Moreover, 52.3% were treatment-experienced patients with up to two treatments prior to raltegravir. Across the study time points, there was a reduction in the viral load and improvement in CD4 counts in both the treatment-naïve and treatment-experienced subgroups. Continuing users of raltegravir reported high treatment satisfaction (55.4 ± 7.2 points).Conclusion: Raltegravir-based regimens seem like a valid therapeutic option in heterogeneous populations of HIV-infected patients, in patients with previous ART experience and as part of first-line therapeutic options alongside with the latest generation of drugs from its class. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-07-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16785 oai:ojs.www.actamedicaportuguesa.com:article/16785 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16785 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/16785 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16785 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16785/6594 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16785/6595 |
dc.rights.driver.fl_str_mv |
Direitos de Autor (c) 2022 Acta Médica Portuguesa info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Direitos de Autor (c) 2022 Acta Médica Portuguesa |
eu_rights_str_mv |
openAccess |
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application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 35 No. 7-8 (2022): July-August; 529-539 Acta Médica Portuguesa; Vol. 35 N.º 7-8 (2022): Julho-Agosto; 529-539 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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