Solubility of Diflunisal in Supercritical Carbon Dioxide
Autor(a) principal: | |
---|---|
Data de Publicação: | 2008 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/10264 https://doi.org/10.1021/je800384h |
Resumo: | The solubility of diflunisal, a nonsteroidal anti-inflammatory drug (NSAID), in supercritical carbon dioxide (scCO2) was measured at (308.2, 318.2, and 328.2) K and in the pressure range from (9.0 up to 25.0) MPa. Results were obtained using a static analytical method. Experimental solubility was found to be between 0.54·10−6 and 8.07·10−6 (in terms of diflunisal mole fraction). Experimental data were satisfactorily correlated with an equation-of-state (EOS) model: the Peng−Robinson cubic equation of state (PR−EOS) together with the conventional van der Waals mixing and combining rules. Solid properties were estimated by different methods available in the literature. The solubilities of several NSAIDs in SCFs, namely in scCO2, were obtained from the literature and plotted and represented as a function of the corresponding sublimation pressures and fusion temperatures. |
id |
RCAP_de224a456260b9172a0932b7488503c5 |
---|---|
oai_identifier_str |
oai:estudogeral.uc.pt:10316/10264 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Solubility of Diflunisal in Supercritical Carbon DioxideThe solubility of diflunisal, a nonsteroidal anti-inflammatory drug (NSAID), in supercritical carbon dioxide (scCO2) was measured at (308.2, 318.2, and 328.2) K and in the pressure range from (9.0 up to 25.0) MPa. Results were obtained using a static analytical method. Experimental solubility was found to be between 0.54·10−6 and 8.07·10−6 (in terms of diflunisal mole fraction). Experimental data were satisfactorily correlated with an equation-of-state (EOS) model: the Peng−Robinson cubic equation of state (PR−EOS) together with the conventional van der Waals mixing and combining rules. Solid properties were estimated by different methods available in the literature. The solubilities of several NSAIDs in SCFs, namely in scCO2, were obtained from the literature and plotted and represented as a function of the corresponding sublimation pressures and fusion temperatures.American Chemical Society2008-08-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/10264http://hdl.handle.net/10316/10264https://doi.org/10.1021/je800384hengJournal of Chemical & Engineering Data. 53:8 (2008) 1990-19950021-9568Coimbra, PatríciaFernandes, DanielGil, Maria H.Sousa, Hermínio C. deinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-05-29T10:05:04Zoai:estudogeral.uc.pt:10316/10264Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:59:13.662401Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Solubility of Diflunisal in Supercritical Carbon Dioxide |
title |
Solubility of Diflunisal in Supercritical Carbon Dioxide |
spellingShingle |
Solubility of Diflunisal in Supercritical Carbon Dioxide Coimbra, Patrícia |
title_short |
Solubility of Diflunisal in Supercritical Carbon Dioxide |
title_full |
Solubility of Diflunisal in Supercritical Carbon Dioxide |
title_fullStr |
Solubility of Diflunisal in Supercritical Carbon Dioxide |
title_full_unstemmed |
Solubility of Diflunisal in Supercritical Carbon Dioxide |
title_sort |
Solubility of Diflunisal in Supercritical Carbon Dioxide |
author |
Coimbra, Patrícia |
author_facet |
Coimbra, Patrícia Fernandes, Daniel Gil, Maria H. Sousa, Hermínio C. de |
author_role |
author |
author2 |
Fernandes, Daniel Gil, Maria H. Sousa, Hermínio C. de |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Coimbra, Patrícia Fernandes, Daniel Gil, Maria H. Sousa, Hermínio C. de |
description |
The solubility of diflunisal, a nonsteroidal anti-inflammatory drug (NSAID), in supercritical carbon dioxide (scCO2) was measured at (308.2, 318.2, and 328.2) K and in the pressure range from (9.0 up to 25.0) MPa. Results were obtained using a static analytical method. Experimental solubility was found to be between 0.54·10−6 and 8.07·10−6 (in terms of diflunisal mole fraction). Experimental data were satisfactorily correlated with an equation-of-state (EOS) model: the Peng−Robinson cubic equation of state (PR−EOS) together with the conventional van der Waals mixing and combining rules. Solid properties were estimated by different methods available in the literature. The solubilities of several NSAIDs in SCFs, namely in scCO2, were obtained from the literature and plotted and represented as a function of the corresponding sublimation pressures and fusion temperatures. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-08-14 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/10264 http://hdl.handle.net/10316/10264 https://doi.org/10.1021/je800384h |
url |
http://hdl.handle.net/10316/10264 https://doi.org/10.1021/je800384h |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Chemical & Engineering Data. 53:8 (2008) 1990-1995 0021-9568 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
American Chemical Society |
publisher.none.fl_str_mv |
American Chemical Society |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799133883581595648 |