Otimização do tratamento da insuficiência cardíaca com fração de ejeção reduzida com fármacos modificadores de prognóstico

Bibliographic Details
Main Author: Silva-Cardoso, José
Publication Date: 2021
Other Authors: Fonseca, Cândida, Franco, Fátima, Morais, João, Ferreira, Jorge, Brito, Dulce
Format: Article
Language: por
Source: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Download full: http://hdl.handle.net/10362/126479
Summary: Funding Information: Medical writer Duarte Oliveira (W4Research) collaborated in the preparation of this article, with financial support from Novartis Portugal. This article contains the authors? opinion on the scientific contents addressed, which are expressed independently of Novartis. Novartis did not participate in the design, discussion of, or writing of this paper. Funding Information: Medical writer Duarte Oliveira (W4Research) collaborated in the preparation of this article, with financial support from Novartis Portugal. This article contains the authors’ opinion on the scientific contents addressed, which are expressed independently of Novartis. Novartis did not participate in the design, discussion of, or writing of this paper. Funding Information: J.S.C. has consulted and received speaker fees, or advisory board participation fees or investigational grants from Abbott, AstraZeneca Pharmaceuticals, Bial, Boehringer Ingelheim, Menarini, Merck Serono, Merck Sharp & Dohme, Novartis, Orion, Pfizer, Sanofi, Servier and Vifor Pharma. C.F. has received speaker and consultancy fees, advisory board participation fees, or investigational grants from Amgen AstraZeneca, Bayer, Bial, Boehringer Ingelheim, Merck Serono, Novartis, Orion, Pfizer, Roche Diagnostics, Servier, Vifor PHarma. F.F. has received speaker and consultancy fees or advisory board participation fees from AstraZeneca, Novartis, and Servier. J.M. has received speaker and consultancy fees, advisory board participation fees or investigational grants from AstraZeneca, Bayer Healthcare, Bial, Ferrer, Menarini, Merck Sharp and Dhome, Merck Portugal, Novartis, Pfizer/BMS, and Servier J.F. reports consultancy and lecture fees from Amgen, Astra-Zeneca, Boehringer Ingelheim and Novartis. D.B. has received speaker and consultancy fees, advisory board participation fees or investigational grants from Amgen, AstraZeneca Pharmaceuticals, Boehringer Ingelheim, Linde Saúde, Merck Portugal, Novartis, Orion, Pfizer, Roche Diagnostics, Servier, and Vifor Pharma. Publisher Copyright: © 2021 Sociedade Portuguesa de Cardiologia
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spelling Otimização do tratamento da insuficiência cardíaca com fração de ejeção reduzida com fármacos modificadores de prognósticoOptimization of heart failure with reduced ejection fraction prognosis-modifying drugsA 2021 heart failure expert consensus paperum documento de consenso de 2021 por especialistas em insuficiência cardíacaBeta-blockersHeart failureHeart failure prognosis-modifying drugsHeart failure with reduced ejection fractionMineralocorticoid receptor antagonistsSacubitril/valsartanSGLT2-inhibitorsTreatment optimizationCardiology and Cardiovascular MedicineSDG 3 - Good Health and Well-beingFunding Information: Medical writer Duarte Oliveira (W4Research) collaborated in the preparation of this article, with financial support from Novartis Portugal. This article contains the authors? opinion on the scientific contents addressed, which are expressed independently of Novartis. Novartis did not participate in the design, discussion of, or writing of this paper. Funding Information: Medical writer Duarte Oliveira (W4Research) collaborated in the preparation of this article, with financial support from Novartis Portugal. This article contains the authors’ opinion on the scientific contents addressed, which are expressed independently of Novartis. Novartis did not participate in the design, discussion of, or writing of this paper. Funding Information: J.S.C. has consulted and received speaker fees, or advisory board participation fees or investigational grants from Abbott, AstraZeneca Pharmaceuticals, Bial, Boehringer Ingelheim, Menarini, Merck Serono, Merck Sharp & Dohme, Novartis, Orion, Pfizer, Sanofi, Servier and Vifor Pharma. C.F. has received speaker and consultancy fees, advisory board participation fees, or investigational grants from Amgen AstraZeneca, Bayer, Bial, Boehringer Ingelheim, Merck Serono, Novartis, Orion, Pfizer, Roche Diagnostics, Servier, Vifor PHarma. F.F. has received speaker and consultancy fees or advisory board participation fees from AstraZeneca, Novartis, and Servier. J.M. has received speaker and consultancy fees, advisory board participation fees or investigational grants from AstraZeneca, Bayer Healthcare, Bial, Ferrer, Menarini, Merck Sharp and Dhome, Merck Portugal, Novartis, Pfizer/BMS, and Servier J.F. reports consultancy and lecture fees from Amgen, Astra-Zeneca, Boehringer Ingelheim and Novartis. D.B. has received speaker and consultancy fees, advisory board participation fees or investigational grants from Amgen, AstraZeneca Pharmaceuticals, Boehringer Ingelheim, Linde Saúde, Merck Portugal, Novartis, Orion, Pfizer, Roche Diagnostics, Servier, and Vifor Pharma. Publisher Copyright: © 2021 Sociedade Portuguesa de CardiologiaHeart failure (HF) with reduced ejection fraction (HFrEF) is associated with high rates of hospitalization and death. It also has a negative impact on patients’ functional capacity and quality of life, as well as on healthcare costs. In recent years, new HFrEF prognosis-modifying drugs have emerged, leading to intense debate within the international scientific community toward a paradigm shift for the management of HFrEF. In this article, we report the contribution of a Portuguese HF expert panel to the ongoing debate. Based on the most recently published clinical evidence, and the panel members’ clinical judgment, three key principles are highlighted: (i) sacubitril/valsartan should be preferred as first-line therapy for HFrEF, instead of an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker; (ii) the four foundation HFrEF drugs are the angiotensin receptor/neprilysin inhibitor, beta-adrenergic blocking agents, mineralocorticoid receptor antagonists, and sodium-glucose co-transporter 2 inhibitors, regardless of the presence of type-2 diabetes mellitus; (iii) these four HFrEF drug classes should be introduced over a short-term period of four to six weeks, guided by a safety protocol, followed by a dose up-titration period of 8 weeks.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNSilva-Cardoso, JoséFonseca, CândidaFranco, FátimaMorais, JoãoFerreira, JorgeBrito, Dulce2021-10-22T03:43:02Z2021-122021-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/126479por0870-2551PURE: 33975041https://doi.org/10.1016/j.repc.2021.07.009info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:06:54Zoai:run.unl.pt:10362/126479Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:45:53.665888Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Otimização do tratamento da insuficiência cardíaca com fração de ejeção reduzida com fármacos modificadores de prognóstico
Optimization of heart failure with reduced ejection fraction prognosis-modifying drugsA 2021 heart failure expert consensus paper
um documento de consenso de 2021 por especialistas em insuficiência cardíaca
title Otimização do tratamento da insuficiência cardíaca com fração de ejeção reduzida com fármacos modificadores de prognóstico
spellingShingle Otimização do tratamento da insuficiência cardíaca com fração de ejeção reduzida com fármacos modificadores de prognóstico
Silva-Cardoso, José
Beta-blockers
Heart failure
Heart failure prognosis-modifying drugs
Heart failure with reduced ejection fraction
Mineralocorticoid receptor antagonists
Sacubitril/valsartan
SGLT2-inhibitors
Treatment optimization
Cardiology and Cardiovascular Medicine
SDG 3 - Good Health and Well-being
title_short Otimização do tratamento da insuficiência cardíaca com fração de ejeção reduzida com fármacos modificadores de prognóstico
title_full Otimização do tratamento da insuficiência cardíaca com fração de ejeção reduzida com fármacos modificadores de prognóstico
title_fullStr Otimização do tratamento da insuficiência cardíaca com fração de ejeção reduzida com fármacos modificadores de prognóstico
title_full_unstemmed Otimização do tratamento da insuficiência cardíaca com fração de ejeção reduzida com fármacos modificadores de prognóstico
title_sort Otimização do tratamento da insuficiência cardíaca com fração de ejeção reduzida com fármacos modificadores de prognóstico
author Silva-Cardoso, José
author_facet Silva-Cardoso, José
Fonseca, Cândida
Franco, Fátima
Morais, João
Ferreira, Jorge
Brito, Dulce
author_role author
author2 Fonseca, Cândida
Franco, Fátima
Morais, João
Ferreira, Jorge
Brito, Dulce
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Silva-Cardoso, José
Fonseca, Cândida
Franco, Fátima
Morais, João
Ferreira, Jorge
Brito, Dulce
dc.subject.por.fl_str_mv Beta-blockers
Heart failure
Heart failure prognosis-modifying drugs
Heart failure with reduced ejection fraction
Mineralocorticoid receptor antagonists
Sacubitril/valsartan
SGLT2-inhibitors
Treatment optimization
Cardiology and Cardiovascular Medicine
SDG 3 - Good Health and Well-being
topic Beta-blockers
Heart failure
Heart failure prognosis-modifying drugs
Heart failure with reduced ejection fraction
Mineralocorticoid receptor antagonists
Sacubitril/valsartan
SGLT2-inhibitors
Treatment optimization
Cardiology and Cardiovascular Medicine
SDG 3 - Good Health and Well-being
description Funding Information: Medical writer Duarte Oliveira (W4Research) collaborated in the preparation of this article, with financial support from Novartis Portugal. This article contains the authors? opinion on the scientific contents addressed, which are expressed independently of Novartis. Novartis did not participate in the design, discussion of, or writing of this paper. Funding Information: Medical writer Duarte Oliveira (W4Research) collaborated in the preparation of this article, with financial support from Novartis Portugal. This article contains the authors’ opinion on the scientific contents addressed, which are expressed independently of Novartis. Novartis did not participate in the design, discussion of, or writing of this paper. Funding Information: J.S.C. has consulted and received speaker fees, or advisory board participation fees or investigational grants from Abbott, AstraZeneca Pharmaceuticals, Bial, Boehringer Ingelheim, Menarini, Merck Serono, Merck Sharp & Dohme, Novartis, Orion, Pfizer, Sanofi, Servier and Vifor Pharma. C.F. has received speaker and consultancy fees, advisory board participation fees, or investigational grants from Amgen AstraZeneca, Bayer, Bial, Boehringer Ingelheim, Merck Serono, Novartis, Orion, Pfizer, Roche Diagnostics, Servier, Vifor PHarma. F.F. has received speaker and consultancy fees or advisory board participation fees from AstraZeneca, Novartis, and Servier. J.M. has received speaker and consultancy fees, advisory board participation fees or investigational grants from AstraZeneca, Bayer Healthcare, Bial, Ferrer, Menarini, Merck Sharp and Dhome, Merck Portugal, Novartis, Pfizer/BMS, and Servier J.F. reports consultancy and lecture fees from Amgen, Astra-Zeneca, Boehringer Ingelheim and Novartis. D.B. has received speaker and consultancy fees, advisory board participation fees or investigational grants from Amgen, AstraZeneca Pharmaceuticals, Boehringer Ingelheim, Linde Saúde, Merck Portugal, Novartis, Orion, Pfizer, Roche Diagnostics, Servier, and Vifor Pharma. Publisher Copyright: © 2021 Sociedade Portuguesa de Cardiologia
publishDate 2021
dc.date.none.fl_str_mv 2021-10-22T03:43:02Z
2021-12
2021-12-01T00:00:00Z
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PURE: 33975041
https://doi.org/10.1016/j.repc.2021.07.009
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