Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer

Detalhes bibliográficos
Autor(a) principal: Costa, Sandra Maria Araújo da
Data de Publicação: 2007
Outros Autores: Pinto, Daniela, Pereira, Deolinda, Vasconcelos, André, Lopes, Carlos Afonso, Osório, Teresa, Lopes, Carlos, Medeiros, Rui
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/5746
Resumo: The purpose of this study was to evaluate the role of XPD genotypes as genetic indicator of susceptibility to ovarian cancer. We have used a case–control study. We analysed DNA samples from 141 ovarian cancer patients and 202 control subjects, for three XPD polymorphisms using PCR-RFLP. We observed that Asn312Asn XPD genotype carriers have increased susceptibility of ovarian cancer (ORZ2.46 95% CI 1.20–5.06; PZ0.015). Furthermore, we found that carriers of Gln751Gln XPD genotype have an increased susceptibility of ovarian cancer (ORZ3.40 95% CI 1.61–7.15; PZ0.001). Asn312Asn and Gln751Gln are particularly associated with an early-stage of disease. Our results suggest an important role for Asn312Asn and Gln751Gln XPD polymorphisms in the susceptibility to ovarian cancer.
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spelling Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancerXPDDNA repairNEROvarian cancerPolymorphismsScience & TechnologyThe purpose of this study was to evaluate the role of XPD genotypes as genetic indicator of susceptibility to ovarian cancer. We have used a case–control study. We analysed DNA samples from 141 ovarian cancer patients and 202 control subjects, for three XPD polymorphisms using PCR-RFLP. We observed that Asn312Asn XPD genotype carriers have increased susceptibility of ovarian cancer (ORZ2.46 95% CI 1.20–5.06; PZ0.015). Furthermore, we found that carriers of Gln751Gln XPD genotype have an increased susceptibility of ovarian cancer (ORZ3.40 95% CI 1.61–7.15; PZ0.001). Asn312Asn and Gln751Gln are particularly associated with an early-stage of disease. Our results suggest an important role for Asn312Asn and Gln751Gln XPD polymorphisms in the susceptibility to ovarian cancer.ElsevierUniversidade do MinhoCosta, Sandra Maria Araújo daPinto, DanielaPereira, DeolindaVasconcelos, AndréLopes, Carlos AfonsoOsório, TeresaLopes, CarlosMedeiros, Rui20072007-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/5746eng"Cancer letters". ISSN 0304-3835. (in Press).0304-383510.1016/j.canlet.2006.03.01416677755info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:29:24Zoai:repositorium.sdum.uminho.pt:1822/5746Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:24:23.093763Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer
title Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer
spellingShingle Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer
Costa, Sandra Maria Araújo da
XPD
DNA repair
NER
Ovarian cancer
Polymorphisms
Science & Technology
title_short Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer
title_full Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer
title_fullStr Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer
title_full_unstemmed Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer
title_sort Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer
author Costa, Sandra Maria Araújo da
author_facet Costa, Sandra Maria Araújo da
Pinto, Daniela
Pereira, Deolinda
Vasconcelos, André
Lopes, Carlos Afonso
Osório, Teresa
Lopes, Carlos
Medeiros, Rui
author_role author
author2 Pinto, Daniela
Pereira, Deolinda
Vasconcelos, André
Lopes, Carlos Afonso
Osório, Teresa
Lopes, Carlos
Medeiros, Rui
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Costa, Sandra Maria Araújo da
Pinto, Daniela
Pereira, Deolinda
Vasconcelos, André
Lopes, Carlos Afonso
Osório, Teresa
Lopes, Carlos
Medeiros, Rui
dc.subject.por.fl_str_mv XPD
DNA repair
NER
Ovarian cancer
Polymorphisms
Science & Technology
topic XPD
DNA repair
NER
Ovarian cancer
Polymorphisms
Science & Technology
description The purpose of this study was to evaluate the role of XPD genotypes as genetic indicator of susceptibility to ovarian cancer. We have used a case–control study. We analysed DNA samples from 141 ovarian cancer patients and 202 control subjects, for three XPD polymorphisms using PCR-RFLP. We observed that Asn312Asn XPD genotype carriers have increased susceptibility of ovarian cancer (ORZ2.46 95% CI 1.20–5.06; PZ0.015). Furthermore, we found that carriers of Gln751Gln XPD genotype have an increased susceptibility of ovarian cancer (ORZ3.40 95% CI 1.61–7.15; PZ0.001). Asn312Asn and Gln751Gln are particularly associated with an early-stage of disease. Our results suggest an important role for Asn312Asn and Gln751Gln XPD polymorphisms in the susceptibility to ovarian cancer.
publishDate 2007
dc.date.none.fl_str_mv 2007
2007-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/5746
url http://hdl.handle.net/1822/5746
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv "Cancer letters". ISSN 0304-3835. (in Press).
0304-3835
10.1016/j.canlet.2006.03.014
16677755
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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