The red seaweed Grateloupia turuturu prevents epidermal dysplasia in HPV16-transgenic mice
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/32785 https://doi.org/10.3390/nu13124529 |
Resumo: | Abstract: The role of dietary profiles in promoting or reducing the risk of multiple types of cancer is increasingly clear, driving the search for balanced foods and nutraceuticals. The red seaweed Grateloupia turuturu has been used as human food showing a balanced nutritional profile. This study aims to test in vivo chemopreventive effects of G. turuturu against cutaneous pre-malignant lesions in transgenic mice for the human papillomavirus type 16 (HPV16). Forty-four female HPV+/− or HPV−/− mice received a standard diet or were supplemented with 10% G. turuturu for 22 consecutive days. Cutaneous lesions (ear and chest skin) were identified histologically. Complementarily, the weights and histology of internal organs as well as blood biochemical and DNA integrity parameters were also assessed. G. turuturu consistently reduced the incidence of epidermal dysplasia induced by HPV16 on both cutaneous sites. Moreover, biochemical, DNA integrity and histological analyses confirmed G. turuturu edibility as no signs of toxicity were found. Dietary supplementation with G. turuturu is an effective and safe chemopreventive strategy in this model. |
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The red seaweed Grateloupia turuturu prevents epidermal dysplasia in HPV16-transgenic miceAbstract: The role of dietary profiles in promoting or reducing the risk of multiple types of cancer is increasingly clear, driving the search for balanced foods and nutraceuticals. The red seaweed Grateloupia turuturu has been used as human food showing a balanced nutritional profile. This study aims to test in vivo chemopreventive effects of G. turuturu against cutaneous pre-malignant lesions in transgenic mice for the human papillomavirus type 16 (HPV16). Forty-four female HPV+/− or HPV−/− mice received a standard diet or were supplemented with 10% G. turuturu for 22 consecutive days. Cutaneous lesions (ear and chest skin) were identified histologically. Complementarily, the weights and histology of internal organs as well as blood biochemical and DNA integrity parameters were also assessed. G. turuturu consistently reduced the incidence of epidermal dysplasia induced by HPV16 on both cutaneous sites. Moreover, biochemical, DNA integrity and histological analyses confirmed G. turuturu edibility as no signs of toxicity were found. Dietary supplementation with G. turuturu is an effective and safe chemopreventive strategy in this model.Nutrients2022-11-17T17:27:44Z2022-11-172021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/32785http://hdl.handle.net/10174/32785https://doi.org/10.3390/nu13124529porndndndndndndndndndndndndndndndAlmeida, JFerreira, TSantos, SPires, MJGil da Costa, RMMedeiros, RBastos, MMSMNeuparth, MJFaustino-Rocha, AIAbreu, APereira, RPacheco, MGaivão, IRosa, EOliveira, PAinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T19:33:33Zoai:dspace.uevora.pt:10174/32785Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:21:35.921934Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The red seaweed Grateloupia turuturu prevents epidermal dysplasia in HPV16-transgenic mice |
title |
The red seaweed Grateloupia turuturu prevents epidermal dysplasia in HPV16-transgenic mice |
spellingShingle |
The red seaweed Grateloupia turuturu prevents epidermal dysplasia in HPV16-transgenic mice Almeida, J |
title_short |
The red seaweed Grateloupia turuturu prevents epidermal dysplasia in HPV16-transgenic mice |
title_full |
The red seaweed Grateloupia turuturu prevents epidermal dysplasia in HPV16-transgenic mice |
title_fullStr |
The red seaweed Grateloupia turuturu prevents epidermal dysplasia in HPV16-transgenic mice |
title_full_unstemmed |
The red seaweed Grateloupia turuturu prevents epidermal dysplasia in HPV16-transgenic mice |
title_sort |
The red seaweed Grateloupia turuturu prevents epidermal dysplasia in HPV16-transgenic mice |
author |
Almeida, J |
author_facet |
Almeida, J Ferreira, T Santos, S Pires, MJ Gil da Costa, RM Medeiros, R Bastos, MMSM Neuparth, MJ Faustino-Rocha, AI Abreu, A Pereira, R Pacheco, M Gaivão, I Rosa, E Oliveira, PA |
author_role |
author |
author2 |
Ferreira, T Santos, S Pires, MJ Gil da Costa, RM Medeiros, R Bastos, MMSM Neuparth, MJ Faustino-Rocha, AI Abreu, A Pereira, R Pacheco, M Gaivão, I Rosa, E Oliveira, PA |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Almeida, J Ferreira, T Santos, S Pires, MJ Gil da Costa, RM Medeiros, R Bastos, MMSM Neuparth, MJ Faustino-Rocha, AI Abreu, A Pereira, R Pacheco, M Gaivão, I Rosa, E Oliveira, PA |
description |
Abstract: The role of dietary profiles in promoting or reducing the risk of multiple types of cancer is increasingly clear, driving the search for balanced foods and nutraceuticals. The red seaweed Grateloupia turuturu has been used as human food showing a balanced nutritional profile. This study aims to test in vivo chemopreventive effects of G. turuturu against cutaneous pre-malignant lesions in transgenic mice for the human papillomavirus type 16 (HPV16). Forty-four female HPV+/− or HPV−/− mice received a standard diet or were supplemented with 10% G. turuturu for 22 consecutive days. Cutaneous lesions (ear and chest skin) were identified histologically. Complementarily, the weights and histology of internal organs as well as blood biochemical and DNA integrity parameters were also assessed. G. turuturu consistently reduced the incidence of epidermal dysplasia induced by HPV16 on both cutaneous sites. Moreover, biochemical, DNA integrity and histological analyses confirmed G. turuturu edibility as no signs of toxicity were found. Dietary supplementation with G. turuturu is an effective and safe chemopreventive strategy in this model. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01T00:00:00Z 2022-11-17T17:27:44Z 2022-11-17 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/32785 http://hdl.handle.net/10174/32785 https://doi.org/10.3390/nu13124529 |
url |
http://hdl.handle.net/10174/32785 https://doi.org/10.3390/nu13124529 |
dc.language.iso.fl_str_mv |
por |
language |
por |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Nutrients |
publisher.none.fl_str_mv |
Nutrients |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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