Fluorescence of a benzothienopyridopyrimidone in solution and in lipid vesicles

Detalhes bibliográficos
Autor(a) principal: Castanheira, Elisabete M. S.
Data de Publicação: 2006
Outros Autores: Pinto, Ana M. R., Queiroz, Maria João R. P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/5578
Resumo: Fluorescence properties of a biologically active benzothienopyridopyrimidone in solution and in lipid vesicles are reported. Assays at different pH values (0.5–10) allowed the determination of pKa = 2.0, showing that this compound may be useful as a pH indicator for pH ≤ 4. In lipid vesicles, benzothienopyridopyrimidone locates in a water-rich environment, indicating that it can be carried in the hydrophilic region of liposomes for drug delivery applications.
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spelling Fluorescence of a benzothienopyridopyrimidone in solution and in lipid vesiclesBenzothienopyridopyrimidonepH probeLipid vesiclesScience & TechnologyFluorescence properties of a biologically active benzothienopyridopyrimidone in solution and in lipid vesicles are reported. Assays at different pH values (0.5–10) allowed the determination of pKa = 2.0, showing that this compound may be useful as a pH indicator for pH ≤ 4. In lipid vesicles, benzothienopyridopyrimidone locates in a water-rich environment, indicating that it can be carried in the hydrophilic region of liposomes for drug delivery applications.Fundação para a Ciência e a Tecnologia (FCT)SpringerUniversidade do MinhoCastanheira, Elisabete M. S.Pinto, Ana M. R.Queiroz, Maria João R. P.2006-032006-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/5578eng"Journal of fluorescence". ISSN 1053-0509. 16:2 (Mar. 2006) 251-257.1053-050910.1007/s10895-005-0050-z16575549The original publication is available at www.springerlink.cominfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:13:40ZPortal AgregadorONG
dc.title.none.fl_str_mv Fluorescence of a benzothienopyridopyrimidone in solution and in lipid vesicles
title Fluorescence of a benzothienopyridopyrimidone in solution and in lipid vesicles
spellingShingle Fluorescence of a benzothienopyridopyrimidone in solution and in lipid vesicles
Castanheira, Elisabete M. S.
Benzothienopyridopyrimidone
pH probe
Lipid vesicles
Science & Technology
title_short Fluorescence of a benzothienopyridopyrimidone in solution and in lipid vesicles
title_full Fluorescence of a benzothienopyridopyrimidone in solution and in lipid vesicles
title_fullStr Fluorescence of a benzothienopyridopyrimidone in solution and in lipid vesicles
title_full_unstemmed Fluorescence of a benzothienopyridopyrimidone in solution and in lipid vesicles
title_sort Fluorescence of a benzothienopyridopyrimidone in solution and in lipid vesicles
author Castanheira, Elisabete M. S.
author_facet Castanheira, Elisabete M. S.
Pinto, Ana M. R.
Queiroz, Maria João R. P.
author_role author
author2 Pinto, Ana M. R.
Queiroz, Maria João R. P.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Castanheira, Elisabete M. S.
Pinto, Ana M. R.
Queiroz, Maria João R. P.
dc.subject.por.fl_str_mv Benzothienopyridopyrimidone
pH probe
Lipid vesicles
Science & Technology
topic Benzothienopyridopyrimidone
pH probe
Lipid vesicles
Science & Technology
description Fluorescence properties of a biologically active benzothienopyridopyrimidone in solution and in lipid vesicles are reported. Assays at different pH values (0.5–10) allowed the determination of pKa = 2.0, showing that this compound may be useful as a pH indicator for pH ≤ 4. In lipid vesicles, benzothienopyridopyrimidone locates in a water-rich environment, indicating that it can be carried in the hydrophilic region of liposomes for drug delivery applications.
publishDate 2006
dc.date.none.fl_str_mv 2006-03
2006-03-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/5578
url http://hdl.handle.net/1822/5578
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv "Journal of fluorescence". ISSN 1053-0509. 16:2 (Mar. 2006) 251-257.
1053-0509
10.1007/s10895-005-0050-z
16575549
The original publication is available at www.springerlink.com
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.mail.fl_str_mv
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