Multi-target analysis of cytostatics in hospital effluents over a 9-month period
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/33849 https://doi.org/10.1016/j.jhazmat.2023.130883 |
Resumo: | The consumption of cytostatics, pharmaceuticals prescribed in chemotherapy, is increasing every year and worldwide, along with the incidence of cancer. The presence and the temporal evolution of cytostatics in wastewaters from a Portuguese hospital center was evaluated through a 9-month sampling campaign, comprising a total of one hundred and twenty-nine samples, collected from May 2019 to February 2020. Eleven cytostatics out of thirteen pharmaceuticals were studied, including flutamide, mycophenolate mofetil and mycophenolic acid, which have never been monitored before. Target analytes were extracted and quantified by solid-phase extraction coupled to liquid-chromatography-tandem mass spectrometry analysis; the method was fully validated. All pharmaceuticals were detected in at least one sample, bicalutamide being the one found with higher frequency (detected in all samples), followed by mycophenolic acid, which was also the compound detected at higher concentrations (up to 5340 ± 211 ng/L). Etoposide, classified as carcinogenic to humans, was detected in 60% of the samples at concentrations up to 142 ± 15 ng/L. The risk from exposure to cytostatics was estimated for aquatic organisms living in receiving bodies. Cyclophosphamide, doxorubicin, etoposide, flutamide, megestrol and mycophenolic acid are suspected to induce risk. Long-term and synergic effects should not be neglected, even for the cytostatics for which no risk was estimated. |
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Multi-target analysis of cytostatics in hospital effluents over a 9-month periodAnticancer drugsHospital wastewatersSolid-phase extractionTemporal trendOccurrenceMass spectrometryToxicityHazardous medicinal productsRiskThe consumption of cytostatics, pharmaceuticals prescribed in chemotherapy, is increasing every year and worldwide, along with the incidence of cancer. The presence and the temporal evolution of cytostatics in wastewaters from a Portuguese hospital center was evaluated through a 9-month sampling campaign, comprising a total of one hundred and twenty-nine samples, collected from May 2019 to February 2020. Eleven cytostatics out of thirteen pharmaceuticals were studied, including flutamide, mycophenolate mofetil and mycophenolic acid, which have never been monitored before. Target analytes were extracted and quantified by solid-phase extraction coupled to liquid-chromatography-tandem mass spectrometry analysis; the method was fully validated. All pharmaceuticals were detected in at least one sample, bicalutamide being the one found with higher frequency (detected in all samples), followed by mycophenolic acid, which was also the compound detected at higher concentrations (up to 5340 ± 211 ng/L). Etoposide, classified as carcinogenic to humans, was detected in 60% of the samples at concentrations up to 142 ± 15 ng/L. The risk from exposure to cytostatics was estimated for aquatic organisms living in receiving bodies. Cyclophosphamide, doxorubicin, etoposide, flutamide, megestrol and mycophenolic acid are suspected to induce risk. Long-term and synergic effects should not be neglected, even for the cytostatics for which no risk was estimated.Journal of Hazardous Materials2023-02-03T12:40:41Z2023-02-032023-04-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/33849http://hdl.handle.net/10174/33849https://doi.org/10.1016/j.jhazmat.2023.130883engGouveia TIA, Silva AMT, Freire MG, Sousa ACA, Alves A, Santos MSF (2023): Multi-target analysis of cytostatics in hospital effluents over a 9-month period. J. Hazard. Mater. 448, 130883https://www.sciencedirect.com/science/article/pii/S0304389423001656?via%3DihubCHRCndndmgfreire@ua.ptacsousa@uevora.ptndnd592Gouveia, T.I.ASilva, A.M.TFreire, M.G.Sousa, A.C.Alves, A.Santos, M.S.F.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-08T04:49:46ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Multi-target analysis of cytostatics in hospital effluents over a 9-month period |
title |
Multi-target analysis of cytostatics in hospital effluents over a 9-month period |
spellingShingle |
Multi-target analysis of cytostatics in hospital effluents over a 9-month period Gouveia, T.I.A Anticancer drugs Hospital wastewaters Solid-phase extraction Temporal trend Occurrence Mass spectrometry Toxicity Hazardous medicinal products Risk |
title_short |
Multi-target analysis of cytostatics in hospital effluents over a 9-month period |
title_full |
Multi-target analysis of cytostatics in hospital effluents over a 9-month period |
title_fullStr |
Multi-target analysis of cytostatics in hospital effluents over a 9-month period |
title_full_unstemmed |
Multi-target analysis of cytostatics in hospital effluents over a 9-month period |
title_sort |
Multi-target analysis of cytostatics in hospital effluents over a 9-month period |
author |
Gouveia, T.I.A |
author_facet |
Gouveia, T.I.A Silva, A.M.T Freire, M.G. Sousa, A.C. Alves, A. Santos, M.S.F. |
author_role |
author |
author2 |
Silva, A.M.T Freire, M.G. Sousa, A.C. Alves, A. Santos, M.S.F. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Gouveia, T.I.A Silva, A.M.T Freire, M.G. Sousa, A.C. Alves, A. Santos, M.S.F. |
dc.subject.por.fl_str_mv |
Anticancer drugs Hospital wastewaters Solid-phase extraction Temporal trend Occurrence Mass spectrometry Toxicity Hazardous medicinal products Risk |
topic |
Anticancer drugs Hospital wastewaters Solid-phase extraction Temporal trend Occurrence Mass spectrometry Toxicity Hazardous medicinal products Risk |
description |
The consumption of cytostatics, pharmaceuticals prescribed in chemotherapy, is increasing every year and worldwide, along with the incidence of cancer. The presence and the temporal evolution of cytostatics in wastewaters from a Portuguese hospital center was evaluated through a 9-month sampling campaign, comprising a total of one hundred and twenty-nine samples, collected from May 2019 to February 2020. Eleven cytostatics out of thirteen pharmaceuticals were studied, including flutamide, mycophenolate mofetil and mycophenolic acid, which have never been monitored before. Target analytes were extracted and quantified by solid-phase extraction coupled to liquid-chromatography-tandem mass spectrometry analysis; the method was fully validated. All pharmaceuticals were detected in at least one sample, bicalutamide being the one found with higher frequency (detected in all samples), followed by mycophenolic acid, which was also the compound detected at higher concentrations (up to 5340 ± 211 ng/L). Etoposide, classified as carcinogenic to humans, was detected in 60% of the samples at concentrations up to 142 ± 15 ng/L. The risk from exposure to cytostatics was estimated for aquatic organisms living in receiving bodies. Cyclophosphamide, doxorubicin, etoposide, flutamide, megestrol and mycophenolic acid are suspected to induce risk. Long-term and synergic effects should not be neglected, even for the cytostatics for which no risk was estimated. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-02-03T12:40:41Z 2023-02-03 2023-04-15T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/33849 http://hdl.handle.net/10174/33849 https://doi.org/10.1016/j.jhazmat.2023.130883 |
url |
http://hdl.handle.net/10174/33849 https://doi.org/10.1016/j.jhazmat.2023.130883 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Gouveia TIA, Silva AMT, Freire MG, Sousa ACA, Alves A, Santos MSF (2023): Multi-target analysis of cytostatics in hospital effluents over a 9-month period. J. Hazard. Mater. 448, 130883 https://www.sciencedirect.com/science/article/pii/S0304389423001656?via%3Dihub CHRC nd nd mgfreire@ua.pt acsousa@uevora.pt nd nd 592 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Journal of Hazardous Materials |
publisher.none.fl_str_mv |
Journal of Hazardous Materials |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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