Urothelial bladder cancer progression: lessons learned from the bench
Autor(a) principal: | |
---|---|
Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/40239 |
Resumo: | Urothelial bladder carcinoma (UBC) is an intricate malignancy with a variable natural history and clinical behavior. Despite developments in diagnosis/prognosis refinement and treatment modalities, the recurrence rate is high, and progression from non-muscle to muscle invasive UBC commonly leads to metastasis. Moreover, patients with muscle-invasive or extra-vesical disease often fail the standard chemotherapy treatment, and overall survival rates are poor. Thus, UBC remains a challenge in the oncology field, representing an ideal candidate for research on biomarkers that could identify patients at increased risk of recurrence, progression, and chemo-refractoriness. However, progress toward personalized medicine has been hampered by the unique genetic complexity of UBC. Recent genome-wide expression and sequencing studies have brought new insights into its molecular features, pathogenesis and clinical diversity, revealing a landscape where classical pathology is intersected by the novel and heterogeneous molecular groups. Hence, it seems plausible to postulate that only an integrated signature of prognostic/predictive biomarkers inherent in different cancer hallmarks will reach clinical validation. In this review, we have summarized ours and others' research into novel putative biomarkers of progression and chemoresistance that encompass several hallmarks of cancer: tumor neovascularization, invasion and metastasis, and energy metabolism reprogramming of the tumor microenvironment. |
id |
RCAP_e564f6f650676c1849b96c3d0ffc485b |
---|---|
oai_identifier_str |
oai:repositorium.sdum.uminho.pt:1822/40239 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Urothelial bladder cancer progression: lessons learned from the benchCD147Lymphovascular invasionMammalian target of rapamycinMonocarboxylate transportersProgressionRaf kinase inhibitor proteinScoring systemUrothelial bladder cancerUrothelial bladder carcinoma (UBC) is an intricate malignancy with a variable natural history and clinical behavior. Despite developments in diagnosis/prognosis refinement and treatment modalities, the recurrence rate is high, and progression from non-muscle to muscle invasive UBC commonly leads to metastasis. Moreover, patients with muscle-invasive or extra-vesical disease often fail the standard chemotherapy treatment, and overall survival rates are poor. Thus, UBC remains a challenge in the oncology field, representing an ideal candidate for research on biomarkers that could identify patients at increased risk of recurrence, progression, and chemo-refractoriness. However, progress toward personalized medicine has been hampered by the unique genetic complexity of UBC. Recent genome-wide expression and sequencing studies have brought new insights into its molecular features, pathogenesis and clinical diversity, revealing a landscape where classical pathology is intersected by the novel and heterogeneous molecular groups. Hence, it seems plausible to postulate that only an integrated signature of prognostic/predictive biomarkers inherent in different cancer hallmarks will reach clinical validation. In this review, we have summarized ours and others' research into novel putative biomarkers of progression and chemoresistance that encompass several hallmarks of cancer: tumor neovascularization, invasion and metastasis, and energy metabolism reprogramming of the tumor microenvironment.OAE Publishing Inc. (OAE)Universidade do MinhoBaltazar, FátimaAfonso, Julieta Alexandra PereiraLongatto Filho, AdhemarReis, R. M.2014-12-182014-12-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/40239por2394-4722http://www.jcmtjournal.com/article.asp?issn=2394-4722;year=2015;volume=1;issue=2;spage=57;epage=66;aulast=Afonsoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:30:43Zoai:repositorium.sdum.uminho.pt:1822/40239Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:25:57.481991Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Urothelial bladder cancer progression: lessons learned from the bench |
title |
Urothelial bladder cancer progression: lessons learned from the bench |
spellingShingle |
Urothelial bladder cancer progression: lessons learned from the bench Baltazar, Fátima CD147 Lymphovascular invasion Mammalian target of rapamycin Monocarboxylate transporters Progression Raf kinase inhibitor protein Scoring system Urothelial bladder cancer |
title_short |
Urothelial bladder cancer progression: lessons learned from the bench |
title_full |
Urothelial bladder cancer progression: lessons learned from the bench |
title_fullStr |
Urothelial bladder cancer progression: lessons learned from the bench |
title_full_unstemmed |
Urothelial bladder cancer progression: lessons learned from the bench |
title_sort |
Urothelial bladder cancer progression: lessons learned from the bench |
author |
Baltazar, Fátima |
author_facet |
Baltazar, Fátima Afonso, Julieta Alexandra Pereira Longatto Filho, Adhemar Reis, R. M. |
author_role |
author |
author2 |
Afonso, Julieta Alexandra Pereira Longatto Filho, Adhemar Reis, R. M. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Baltazar, Fátima Afonso, Julieta Alexandra Pereira Longatto Filho, Adhemar Reis, R. M. |
dc.subject.por.fl_str_mv |
CD147 Lymphovascular invasion Mammalian target of rapamycin Monocarboxylate transporters Progression Raf kinase inhibitor protein Scoring system Urothelial bladder cancer |
topic |
CD147 Lymphovascular invasion Mammalian target of rapamycin Monocarboxylate transporters Progression Raf kinase inhibitor protein Scoring system Urothelial bladder cancer |
description |
Urothelial bladder carcinoma (UBC) is an intricate malignancy with a variable natural history and clinical behavior. Despite developments in diagnosis/prognosis refinement and treatment modalities, the recurrence rate is high, and progression from non-muscle to muscle invasive UBC commonly leads to metastasis. Moreover, patients with muscle-invasive or extra-vesical disease often fail the standard chemotherapy treatment, and overall survival rates are poor. Thus, UBC remains a challenge in the oncology field, representing an ideal candidate for research on biomarkers that could identify patients at increased risk of recurrence, progression, and chemo-refractoriness. However, progress toward personalized medicine has been hampered by the unique genetic complexity of UBC. Recent genome-wide expression and sequencing studies have brought new insights into its molecular features, pathogenesis and clinical diversity, revealing a landscape where classical pathology is intersected by the novel and heterogeneous molecular groups. Hence, it seems plausible to postulate that only an integrated signature of prognostic/predictive biomarkers inherent in different cancer hallmarks will reach clinical validation. In this review, we have summarized ours and others' research into novel putative biomarkers of progression and chemoresistance that encompass several hallmarks of cancer: tumor neovascularization, invasion and metastasis, and energy metabolism reprogramming of the tumor microenvironment. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-18 2014-12-18T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/40239 |
url |
http://hdl.handle.net/1822/40239 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
2394-4722 http://www.jcmtjournal.com/article.asp?issn=2394-4722;year=2015;volume=1;issue=2;spage=57;epage=66;aulast=Afonso |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
OAE Publishing Inc. (OAE) |
publisher.none.fl_str_mv |
OAE Publishing Inc. (OAE) |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799132745415262208 |