Anopheles gambiae on remote islands in the Indian Ocean
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/165015 |
Resumo: | Funding Information: We thank the National Malaria Control Program personnel from the Union of the Comoros for facilitating field collections in the islands. We thank the team of the Medical Entomology Unit of the Institut Pasteur de Madagascar for collecting and processing specimens from Madagascar. Funding Information: This work was supported by grants from the UC Irvine Malaria Initiative Program (A17- 0209) and Open Philanthropy (A20-3521). Publisher Copyright: © 2023, The Author(s). |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Anopheles gambiae on remote islands in the Indian Oceanorigins and prospects for malaria elimination by genetic modification of extant populationsQR MicrobiologyRA0421 Public health. Hygiene. Preventive MedicineGeneralInfectious DiseasesMolecular BiologyApplied Microbiology and BiotechnologySDG 3 - Good Health and Well-beingSDG 9 - Industry, Innovation, and InfrastructureFunding Information: We thank the National Malaria Control Program personnel from the Union of the Comoros for facilitating field collections in the islands. We thank the team of the Medical Entomology Unit of the Institut Pasteur de Madagascar for collecting and processing specimens from Madagascar. Funding Information: This work was supported by grants from the UC Irvine Malaria Initiative Program (A17- 0209) and Open Philanthropy (A20-3521). Publisher Copyright: © 2023, The Author(s).The mosquito Anopheles gambiae s.s. is a primary malaria vector throughout sub-Saharan Africa including the islands of the Comoros archipelago (Anjouan, Grande Comore, Mayotte and Mohéli). These islands are located at the northern end of the Mozambique Channel in eastern Africa. Previous studies have shown a relatively high degree of genetic isolation between the Comoros islands and mainland populations of A. gambiae, but the origin of the island populations remains unclear. Here, we analyzed phylogenetic relationships among island and mainland populations using complete mitochondrial genome sequences of individual A. gambiae specimens. This work augments earlier studies based on analysis of the nuclear genome. We investigated the source population of A. gambiae for each island, estimated the number of introductions, when they occurred and explored evidence for contemporary gene flow between island and mainland populations. These studies are relevant to understanding historical patterns in the dispersal of this important malaria vector and provide information critical to assessing their potential for the exploration of genetic-based vector control methods to eliminate this disease. Phylogenetic analysis and haplotype networks were constructed from mitogenome sequences of 258 A. gambiae from the four islands. In addition, 112 individuals from seven countries across sub-Saharan Africa and Madagascar were included to identify potential source populations. Our results suggest that introduction events of A. gambiae into the Comoros archipelago were rare and recent events and support earlier claims that gene flow between the mainland and these islands is limited. This study is concordant with earlier work suggesting the suitability of these oceanic islands as appropriate sites for conducting field trial releases of genetically engineered mosquitoes (GEMs).Vector borne diseases and pathogens (VBD)Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)RUNDitter, Robert E.Campos, MelinaCrepeau, Marc W.Pinto, JoãoToilibou, AliAmina, YssoufTantely, Luciano MichaëlGirod, RomainLee, YoosookCornel, Anthony J.Lanzaro, Gregory C.2024-03-15T23:49:00Z2023-122023-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10application/pdfhttp://hdl.handle.net/10362/165015eng2045-2322PURE: 82961748https://doi.org/10.1038/s41598-023-44501-zinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-18T01:49:00Zoai:run.unl.pt:10362/165015Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T04:02:07.393069Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Anopheles gambiae on remote islands in the Indian Ocean origins and prospects for malaria elimination by genetic modification of extant populations |
| title |
Anopheles gambiae on remote islands in the Indian Ocean |
| spellingShingle |
Anopheles gambiae on remote islands in the Indian Ocean Ditter, Robert E. QR Microbiology RA0421 Public health. Hygiene. Preventive Medicine General Infectious Diseases Molecular Biology Applied Microbiology and Biotechnology SDG 3 - Good Health and Well-being SDG 9 - Industry, Innovation, and Infrastructure |
| title_short |
Anopheles gambiae on remote islands in the Indian Ocean |
| title_full |
Anopheles gambiae on remote islands in the Indian Ocean |
| title_fullStr |
Anopheles gambiae on remote islands in the Indian Ocean |
| title_full_unstemmed |
Anopheles gambiae on remote islands in the Indian Ocean |
| title_sort |
Anopheles gambiae on remote islands in the Indian Ocean |
| author |
Ditter, Robert E. |
| author_facet |
Ditter, Robert E. Campos, Melina Crepeau, Marc W. Pinto, João Toilibou, Ali Amina, Yssouf Tantely, Luciano Michaël Girod, Romain Lee, Yoosook Cornel, Anthony J. Lanzaro, Gregory C. |
| author_role |
author |
| author2 |
Campos, Melina Crepeau, Marc W. Pinto, João Toilibou, Ali Amina, Yssouf Tantely, Luciano Michaël Girod, Romain Lee, Yoosook Cornel, Anthony J. Lanzaro, Gregory C. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Vector borne diseases and pathogens (VBD) Instituto de Higiene e Medicina Tropical (IHMT) Global Health and Tropical Medicine (GHTM) RUN |
| dc.contributor.author.fl_str_mv |
Ditter, Robert E. Campos, Melina Crepeau, Marc W. Pinto, João Toilibou, Ali Amina, Yssouf Tantely, Luciano Michaël Girod, Romain Lee, Yoosook Cornel, Anthony J. Lanzaro, Gregory C. |
| dc.subject.por.fl_str_mv |
QR Microbiology RA0421 Public health. Hygiene. Preventive Medicine General Infectious Diseases Molecular Biology Applied Microbiology and Biotechnology SDG 3 - Good Health and Well-being SDG 9 - Industry, Innovation, and Infrastructure |
| topic |
QR Microbiology RA0421 Public health. Hygiene. Preventive Medicine General Infectious Diseases Molecular Biology Applied Microbiology and Biotechnology SDG 3 - Good Health and Well-being SDG 9 - Industry, Innovation, and Infrastructure |
| description |
Funding Information: We thank the National Malaria Control Program personnel from the Union of the Comoros for facilitating field collections in the islands. We thank the team of the Medical Entomology Unit of the Institut Pasteur de Madagascar for collecting and processing specimens from Madagascar. Funding Information: This work was supported by grants from the UC Irvine Malaria Initiative Program (A17- 0209) and Open Philanthropy (A20-3521). Publisher Copyright: © 2023, The Author(s). |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-12 2023-12-01T00:00:00Z 2024-03-15T23:49:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/165015 |
| url |
http://hdl.handle.net/10362/165015 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2045-2322 PURE: 82961748 https://doi.org/10.1038/s41598-023-44501-z |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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10 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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