HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure

Detalhes bibliográficos
Autor(a) principal: Jones, Kate
Data de Publicação: 2022
Outros Autores: Galea, Karen S., Scholten, Bernice, Loikala, Marika, Porras, Simo P., Bousoumah, Radia, Ndaw, Sophie, Leese, Elizabeth, Louro, Henriqueta, Silva, Maria João, Viegas, Susana, Godderis, Lode, Verdonck, Jelle, Poels, Katrien, Gӧen, Thomas, Duca, Radu-Corneliu, Santonen, Tiina, HBM4EU Diisocyanates Study Team
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/8371
Resumo: This article belongs to the Section Occupational Safety and Health.
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spelling HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational ExposureEnvironmental GenotoxicityHuman BiomonitoringOccupational ExposureDiisocyanatesBiomarkersExposure AssessmentWorkersGenotoxicidade AmbientalThis article belongs to the Section Occupational Safety and Health.Diisocyanates have long been a leading cause of occupational asthma in Europe, and recently, they have been subjected to a restriction under the REACH regulations. As part of the European Human Biomonitoring project (HBM4EU), we present a study protocol designed to assessoccupational exposure to diisocyanates in five European countries. The objectives of the study are to assess exposure in a number of sectors that have not been widely reported on in the past (for example, the manufacturing of large vehicles, such as in aerospace; the construction sector, where there are potentially several sources of exposure (e.g., sprayed insulation, floor screeds); the use of MDI-based glues, and the manufacture of spray adhesives or coatings) to test the usability of different biomarkers in the assessment of exposure to diisocyanates and to provide background data for regulatory purposes. The study will collect urine samples (analysed for diisocyanate-derived diamines and acetyl–MDI–lysine), blood samples (analysed for diisocyanate-specific IgE and IgG antibodies, inflammatory markers, and diisocyanate-specific Hb adducts for MDI), and buccal cells(micronucleus analysis) and measure fractional exhaled nitric oxide. In addition, occupational hygienemeasurements (air monitoring and skin wipe samples) and questionnaire data will be collected. The protocol is harmonised across the participating countries to enable pooling of data, leading to better and more robust insights and recommendations.This work has received external funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 733032 and received co-funding from the author’s organizations and/or Ministries.MDPIRepositório Científico do Instituto Nacional de SaúdeJones, KateGalea, Karen S.Scholten, BerniceLoikala, MarikaPorras, Simo P.Bousoumah, RadiaNdaw, SophieLeese, ElizabethLouro, HenriquetaSilva, Maria JoãoViegas, SusanaGodderis, LodeVerdonck, JellePoels, KatrienGӧen, ThomasDuca, Radu-CorneliuSantonen, TiinaHBM4EU Diisocyanates Study Team2022-12-02T15:16:24Z2022-06-202022-06-20T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8371engInt J Environ Res Public Health. 2022 Jul 20;19(14):8811. doi: 10.3390/ijerph191488111661-782710.3390/ijerph19148811info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:29Zoai:repositorio.insa.pt:10400.18/8371Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:42:55.762059Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure
title HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure
spellingShingle HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure
Jones, Kate
Environmental Genotoxicity
Human Biomonitoring
Occupational Exposure
Diisocyanates
Biomarkers
Exposure Assessment
Workers
Genotoxicidade Ambiental
title_short HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure
title_full HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure
title_fullStr HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure
title_full_unstemmed HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure
title_sort HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure
author Jones, Kate
author_facet Jones, Kate
Galea, Karen S.
Scholten, Bernice
Loikala, Marika
Porras, Simo P.
Bousoumah, Radia
Ndaw, Sophie
Leese, Elizabeth
Louro, Henriqueta
Silva, Maria João
Viegas, Susana
Godderis, Lode
Verdonck, Jelle
Poels, Katrien
Gӧen, Thomas
Duca, Radu-Corneliu
Santonen, Tiina
HBM4EU Diisocyanates Study Team
author_role author
author2 Galea, Karen S.
Scholten, Bernice
Loikala, Marika
Porras, Simo P.
Bousoumah, Radia
Ndaw, Sophie
Leese, Elizabeth
Louro, Henriqueta
Silva, Maria João
Viegas, Susana
Godderis, Lode
Verdonck, Jelle
Poels, Katrien
Gӧen, Thomas
Duca, Radu-Corneliu
Santonen, Tiina
HBM4EU Diisocyanates Study Team
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Jones, Kate
Galea, Karen S.
Scholten, Bernice
Loikala, Marika
Porras, Simo P.
Bousoumah, Radia
Ndaw, Sophie
Leese, Elizabeth
Louro, Henriqueta
Silva, Maria João
Viegas, Susana
Godderis, Lode
Verdonck, Jelle
Poels, Katrien
Gӧen, Thomas
Duca, Radu-Corneliu
Santonen, Tiina
HBM4EU Diisocyanates Study Team
dc.subject.por.fl_str_mv Environmental Genotoxicity
Human Biomonitoring
Occupational Exposure
Diisocyanates
Biomarkers
Exposure Assessment
Workers
Genotoxicidade Ambiental
topic Environmental Genotoxicity
Human Biomonitoring
Occupational Exposure
Diisocyanates
Biomarkers
Exposure Assessment
Workers
Genotoxicidade Ambiental
description This article belongs to the Section Occupational Safety and Health.
publishDate 2022
dc.date.none.fl_str_mv 2022-12-02T15:16:24Z
2022-06-20
2022-06-20T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/8371
url http://hdl.handle.net/10400.18/8371
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Int J Environ Res Public Health. 2022 Jul 20;19(14):8811. doi: 10.3390/ijerph19148811
1661-7827
10.3390/ijerph19148811
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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