Safety and Effectiveness of the Genous Endothelial Progenitor Cell-Capture Stent: Follow-Up to 5 Years
Main Author: | |
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Publication Date: | 2013 |
Other Authors: | , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Download full: | http://hdl.handle.net/10400.17/1599 |
Summary: | AIMS: To evaluate the long-term clinical outcomes following percutaneous coronary intervention (PCI) with the Genous stent in an unselected population. METHODS: All patients admitted to a single center who underwent PCI using the GS exclusively, between May 2006 and May 2012, were enrolled, and a clinical follow-up of up to 60 months was carried out. The primary endpoint of major adverse cardiac event (MACE) rate was defined as the composite of cardiac death, acute myocardial infarction (AMI), and target lesion revascularization (TLR). RESULTS: Of the 450 patients included (75.1% male; 65.5 ± 11.7 years), 28.4% were diabetic and acute coronary syndrome was the reason for PCI in 76.4%. Angioplasty was performed in 524 lesions using 597 Genous stents, with angiographic success in 97.1%. At a median of 36 months of follow-up (range, 1-75 months), MACE, AMI, TLR, stent restenosis (SR), and stent thrombosis (ST) rates were 15.6%, 8.4%, 4.4%, 3.8%, and 2.2%, respectively. Between 12 and 24 months, the TLR, SR, and ST rates practically stabilized, up to 60 months. Bifurcation lesions were independently associated with MACE, TLR, and SR. CONCLUSION: This is the first study reporting clinical results with the Genous stent up to 60 months. The Genous stent was safe and effective in the long-term, in an unselected population. |
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Safety and Effectiveness of the Genous Endothelial Progenitor Cell-Capture Stent: Follow-Up to 5 YearsHSM CARAcute Coronary Syndrome/pathologyAcute Coronary Syndrome/therapyCoronary Restenosis/epidemiologyCoronary Thrombosis/epidemiologyEndothelial Progenitor Cells/pathologyFollow-Up StudiesLongitudinal StudiesMyocardial Infarction/epidemiologyPercutaneous Coronary Intervention/instrumentationPercutaneous Coronary Intervention/methodsProportional Hazards ModelsStents*/adverse effectsRetrospective StudiesRisk FactorsAIMS: To evaluate the long-term clinical outcomes following percutaneous coronary intervention (PCI) with the Genous stent in an unselected population. METHODS: All patients admitted to a single center who underwent PCI using the GS exclusively, between May 2006 and May 2012, were enrolled, and a clinical follow-up of up to 60 months was carried out. The primary endpoint of major adverse cardiac event (MACE) rate was defined as the composite of cardiac death, acute myocardial infarction (AMI), and target lesion revascularization (TLR). RESULTS: Of the 450 patients included (75.1% male; 65.5 ± 11.7 years), 28.4% were diabetic and acute coronary syndrome was the reason for PCI in 76.4%. Angioplasty was performed in 524 lesions using 597 Genous stents, with angiographic success in 97.1%. At a median of 36 months of follow-up (range, 1-75 months), MACE, AMI, TLR, stent restenosis (SR), and stent thrombosis (ST) rates were 15.6%, 8.4%, 4.4%, 3.8%, and 2.2%, respectively. Between 12 and 24 months, the TLR, SR, and ST rates practically stabilized, up to 60 months. Bifurcation lesions were independently associated with MACE, TLR, and SR. CONCLUSION: This is the first study reporting clinical results with the Genous stent up to 60 months. The Genous stent was safe and effective in the long-term, in an unselected population.Repositório do Centro Hospitalar Universitário de Lisboa Central, EPEPereira-da-Silva, TBernardes, TCacela, DFiarresga, ASousa, LPatrício, LCruz Ferreira, R2013-12-19T10:53:26Z20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/1599engJ Invasive Cardiol. 2013 Dec;25(12):666-9info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:32:24Zoai:repositorio.chlc.min-saude.pt:10400.17/1599Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:19:03.674711Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Safety and Effectiveness of the Genous Endothelial Progenitor Cell-Capture Stent: Follow-Up to 5 Years |
title |
Safety and Effectiveness of the Genous Endothelial Progenitor Cell-Capture Stent: Follow-Up to 5 Years |
spellingShingle |
Safety and Effectiveness of the Genous Endothelial Progenitor Cell-Capture Stent: Follow-Up to 5 Years Pereira-da-Silva, T HSM CAR Acute Coronary Syndrome/pathology Acute Coronary Syndrome/therapy Coronary Restenosis/epidemiology Coronary Thrombosis/epidemiology Endothelial Progenitor Cells/pathology Follow-Up Studies Longitudinal Studies Myocardial Infarction/epidemiology Percutaneous Coronary Intervention/instrumentation Percutaneous Coronary Intervention/methods Proportional Hazards Models Stents*/adverse effects Retrospective Studies Risk Factors |
title_short |
Safety and Effectiveness of the Genous Endothelial Progenitor Cell-Capture Stent: Follow-Up to 5 Years |
title_full |
Safety and Effectiveness of the Genous Endothelial Progenitor Cell-Capture Stent: Follow-Up to 5 Years |
title_fullStr |
Safety and Effectiveness of the Genous Endothelial Progenitor Cell-Capture Stent: Follow-Up to 5 Years |
title_full_unstemmed |
Safety and Effectiveness of the Genous Endothelial Progenitor Cell-Capture Stent: Follow-Up to 5 Years |
title_sort |
Safety and Effectiveness of the Genous Endothelial Progenitor Cell-Capture Stent: Follow-Up to 5 Years |
author |
Pereira-da-Silva, T |
author_facet |
Pereira-da-Silva, T Bernardes, T Cacela, D Fiarresga, A Sousa, L Patrício, L Cruz Ferreira, R |
author_role |
author |
author2 |
Bernardes, T Cacela, D Fiarresga, A Sousa, L Patrício, L Cruz Ferreira, R |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Pereira-da-Silva, T Bernardes, T Cacela, D Fiarresga, A Sousa, L Patrício, L Cruz Ferreira, R |
dc.subject.por.fl_str_mv |
HSM CAR Acute Coronary Syndrome/pathology Acute Coronary Syndrome/therapy Coronary Restenosis/epidemiology Coronary Thrombosis/epidemiology Endothelial Progenitor Cells/pathology Follow-Up Studies Longitudinal Studies Myocardial Infarction/epidemiology Percutaneous Coronary Intervention/instrumentation Percutaneous Coronary Intervention/methods Proportional Hazards Models Stents*/adverse effects Retrospective Studies Risk Factors |
topic |
HSM CAR Acute Coronary Syndrome/pathology Acute Coronary Syndrome/therapy Coronary Restenosis/epidemiology Coronary Thrombosis/epidemiology Endothelial Progenitor Cells/pathology Follow-Up Studies Longitudinal Studies Myocardial Infarction/epidemiology Percutaneous Coronary Intervention/instrumentation Percutaneous Coronary Intervention/methods Proportional Hazards Models Stents*/adverse effects Retrospective Studies Risk Factors |
description |
AIMS: To evaluate the long-term clinical outcomes following percutaneous coronary intervention (PCI) with the Genous stent in an unselected population. METHODS: All patients admitted to a single center who underwent PCI using the GS exclusively, between May 2006 and May 2012, were enrolled, and a clinical follow-up of up to 60 months was carried out. The primary endpoint of major adverse cardiac event (MACE) rate was defined as the composite of cardiac death, acute myocardial infarction (AMI), and target lesion revascularization (TLR). RESULTS: Of the 450 patients included (75.1% male; 65.5 ± 11.7 years), 28.4% were diabetic and acute coronary syndrome was the reason for PCI in 76.4%. Angioplasty was performed in 524 lesions using 597 Genous stents, with angiographic success in 97.1%. At a median of 36 months of follow-up (range, 1-75 months), MACE, AMI, TLR, stent restenosis (SR), and stent thrombosis (ST) rates were 15.6%, 8.4%, 4.4%, 3.8%, and 2.2%, respectively. Between 12 and 24 months, the TLR, SR, and ST rates practically stabilized, up to 60 months. Bifurcation lesions were independently associated with MACE, TLR, and SR. CONCLUSION: This is the first study reporting clinical results with the Genous stent up to 60 months. The Genous stent was safe and effective in the long-term, in an unselected population. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-12-19T10:53:26Z 2013 2013-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/1599 |
url |
http://hdl.handle.net/10400.17/1599 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
J Invasive Cardiol. 2013 Dec;25(12):666-9 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799131288094900224 |