Insights into angiogenesis in non-small cell lung cancer : molecular mechanisms, polymorphic genes, and targeted therapies

Detalhes bibliográficos
Autor(a) principal: Mello, Ramon Andrade de
Data de Publicação: 2012
Outros Autores: Costa, Bruno Marques, Reis, R. M., Hespanhol, Venceslau
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/16675
Resumo: We would like to thank Dr. Miguel Nunes from Department of Informatic of Faculty of Medicine of the University of Porto, Porto, Portugal, for his help in technical support, and Prof. Henrique Queiroga, Department of Pneumology of Faculty of Medicine of the University of Porto, Porto, Portugal, for his critical contribution in this manuscript review
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spelling Insights into angiogenesis in non-small cell lung cancer : molecular mechanisms, polymorphic genes, and targeted therapiesAngiogenesisAntineoplastic drug combinationBiological markersNeovascularizationNon-small cell lung cancerPathologyPolymorphismVascular endothelial growth factorTumor Vessel CreationVEGF pathwayScience & TechnologyWe would like to thank Dr. Miguel Nunes from Department of Informatic of Faculty of Medicine of the University of Porto, Porto, Portugal, for his help in technical support, and Prof. Henrique Queiroga, Department of Pneumology of Faculty of Medicine of the University of Porto, Porto, Portugal, for his critical contribution in this manuscript reviewLung cancer is a highly prevalent disease worldwide. Currently, there are more than 150 million patients with lung cancer in the world, with more than 1 million new cases diagnosed per year. Tumoral angiogenesis is an important hallmark of this disease, but despite being extensively studied, the complete angiogenic mechanisms are not fully elucidated. Recent studies have reported a correlation between pharmacological inhibition of these angiogenic mechanisms and improvement of overall survival in lung cancer patients, mainly for those in advanced stages. The family of vascular endothelial growth factor (VEGF) proteins has critical roles in tumoral angiogenesis. An interaction between VEGF-A and VEGF receptor 2 (VEGFR-2) is the main pathway of activation and maintenance of angiogenesis. In tumors, this process is intimately correlative with progression and metastasis. Some studies suggested that serum levels of VEGF are higher in patients with lung cancer, especially in some types of non-small cell lung cancer (NSCLC). Other studies revealed that genetic polymorphisms of VEGF correlate with susceptibility, prognosis, and therapeutic response of some patients with NSCLC. This paper aims to review the impact of angiogenesis, especially on VEGF pathways, in NSCLC, and highlights the relevance of known and new patents disclosed of anti-angiogenic therapies in these patients.Bentham Science PublishersUniversidade do MinhoMello, Ramon Andrade deCosta, Bruno MarquesReis, R. M.Hespanhol, Venceslau2012-012012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/16675eng1574-892821854359http://www.benthamdirect.org/pages/content.php?PRA/2012/00000007/00000001/0009PRA.SGMinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:38:58Zoai:repositorium.sdum.uminho.pt:1822/16675Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:35:30.826784Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Insights into angiogenesis in non-small cell lung cancer : molecular mechanisms, polymorphic genes, and targeted therapies
title Insights into angiogenesis in non-small cell lung cancer : molecular mechanisms, polymorphic genes, and targeted therapies
spellingShingle Insights into angiogenesis in non-small cell lung cancer : molecular mechanisms, polymorphic genes, and targeted therapies
Mello, Ramon Andrade de
Angiogenesis
Antineoplastic drug combination
Biological markers
Neovascularization
Non-small cell lung cancer
Pathology
Polymorphism
Vascular endothelial growth factor
Tumor Vessel Creation
VEGF pathway
Science & Technology
title_short Insights into angiogenesis in non-small cell lung cancer : molecular mechanisms, polymorphic genes, and targeted therapies
title_full Insights into angiogenesis in non-small cell lung cancer : molecular mechanisms, polymorphic genes, and targeted therapies
title_fullStr Insights into angiogenesis in non-small cell lung cancer : molecular mechanisms, polymorphic genes, and targeted therapies
title_full_unstemmed Insights into angiogenesis in non-small cell lung cancer : molecular mechanisms, polymorphic genes, and targeted therapies
title_sort Insights into angiogenesis in non-small cell lung cancer : molecular mechanisms, polymorphic genes, and targeted therapies
author Mello, Ramon Andrade de
author_facet Mello, Ramon Andrade de
Costa, Bruno Marques
Reis, R. M.
Hespanhol, Venceslau
author_role author
author2 Costa, Bruno Marques
Reis, R. M.
Hespanhol, Venceslau
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Mello, Ramon Andrade de
Costa, Bruno Marques
Reis, R. M.
Hespanhol, Venceslau
dc.subject.por.fl_str_mv Angiogenesis
Antineoplastic drug combination
Biological markers
Neovascularization
Non-small cell lung cancer
Pathology
Polymorphism
Vascular endothelial growth factor
Tumor Vessel Creation
VEGF pathway
Science & Technology
topic Angiogenesis
Antineoplastic drug combination
Biological markers
Neovascularization
Non-small cell lung cancer
Pathology
Polymorphism
Vascular endothelial growth factor
Tumor Vessel Creation
VEGF pathway
Science & Technology
description We would like to thank Dr. Miguel Nunes from Department of Informatic of Faculty of Medicine of the University of Porto, Porto, Portugal, for his help in technical support, and Prof. Henrique Queiroga, Department of Pneumology of Faculty of Medicine of the University of Porto, Porto, Portugal, for his critical contribution in this manuscript review
publishDate 2012
dc.date.none.fl_str_mv 2012-01
2012-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/16675
url http://hdl.handle.net/1822/16675
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1574-8928
21854359
http://www.benthamdirect.org/pages/content.php?PRA/2012/00000007/00000001/0009PRA.SGM
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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