COVID-19 Vaccination in Liver Cirrhosis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/162705 |
Resumo: | Funding Information: This study was funded by Associação Portuguesa para o Estudo do Fígado, which supported the costs of the antibody titer analysis of every patient at each timepoint. Publisher Copyright: © 2023 The Author(s). Published by S. Karger AG, Basel. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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COVID-19 Vaccination in Liver CirrhosisSafety and Immune and Clinical ResponsesAntibodiesCOVID-19InfectionLiver cirrhosisVaccineGastroenterologySDG 3 - Good Health and Well-beingFunding Information: This study was funded by Associação Portuguesa para o Estudo do Fígado, which supported the costs of the antibody titer analysis of every patient at each timepoint. Publisher Copyright: © 2023 The Author(s). Published by S. Karger AG, Basel.Introduction: Three years after the beginning of the SARSCoV-2 pandemic, the safety and efficacy of COVID-19 vaccination in liver cirrhosis (LC) patients remain controversial. We aimed to study the safety, immunological, and clinical responses of LC patients to COVID-19 vaccination. Methods: Prospective multicentric study in adults with LC eligible for COVID-19 vaccination, without prior known infection. Patients were followed up until the timing of a booster dose, SARS-CoV-2 infection, or death. Spike-protein immunoglobulin G antibody titers for SARS-CoV-2 at 2 weeks, 3 months, and 6 months postvaccination were assessed. Antibody titers <33.8 binding antibody units (BAU)/mL were considered seronegative and <200 BAU/mL suboptimal. Postvaccination infection and its severity were registered. Results: We included 124 LC patients, 81% males, mean aged 61 ± 10 years, with a mean follow-up of 221 ± 26 days. Alcohol was the most common (61%) cause of cirrhosis, and 7% were under immunosuppressants for autoimmune hepatitis; 69% had portal hypertension, 42% had a previous decompensation, and 21% had a Child-Pugh-Turcotte score of B/C. The type of vaccine administrated was BNT162b2 (n = 59, 48%), ChAdOx1nCoV-19 (n = 45, 36%), mRNA-1273 (n = 14, 11%), and Ad26.COV2.S (n = 6, 5%). Eighteen percent of the patients reported adverse events after vaccination, none serious. Median [Q1; Q3] antibody titers were 1,185 [280; 2,080] BAU/mL at 2 weeks, 301 [72; 1,175] BAU/mL at 3 months, and 192 [49; 656] BAU/mL at 6 months. There were seronegative and suboptimal antibody responses in 8% and 23% of the patients at 2 weeks, 16% and 38% at 3 months, and 22% and 48% at 6 months. Older age and adenovirus vector vaccines were the only factors associated with seronegative and suboptimal responses at 2 weeks and 3 months (p < 0.05) in a multivariable logistic regression analysis. Eleven patients (9%) were infected with SARS-CoV-2 during follow-up (3.8–6.6 months postvaccination), all with mild disease. There were no differences regarding the type of vaccine, and 73% had antibody titers >200 BAU/mL at 3 months. Conclusion: COVID-19 vaccines in patients with LC were safe, without serious adverse events. The humoral and clinical responses were similar to the reported for the general population. Humoral response was adversely impacted by older age and adenovirus vector vaccines and unrelated to the liver disease severity.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNCanha, Maria InêsCunha, Mário JorgeSilva, Maria AzevedoCosta, Mara SarmentoSaraiva, Rita OrnelasRuge, AndréMachado, Mariana VerdelhoFélix, Catarina SousaMorão, BárbaraFigueiredo, Pedro NarraMendes, MilenaLeal, CarinaCalinas, Filipe2024-01-24T16:59:47Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/162705eng2341-4545PURE: 81978073https://doi.org/10.1159/000534740info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:45:39Zoai:run.unl.pt:10362/162705Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:59:01.918809Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
COVID-19 Vaccination in Liver Cirrhosis Safety and Immune and Clinical Responses |
| title |
COVID-19 Vaccination in Liver Cirrhosis |
| spellingShingle |
COVID-19 Vaccination in Liver Cirrhosis Canha, Maria Inês Antibodies COVID-19 Infection Liver cirrhosis Vaccine Gastroenterology SDG 3 - Good Health and Well-being |
| title_short |
COVID-19 Vaccination in Liver Cirrhosis |
| title_full |
COVID-19 Vaccination in Liver Cirrhosis |
| title_fullStr |
COVID-19 Vaccination in Liver Cirrhosis |
| title_full_unstemmed |
COVID-19 Vaccination in Liver Cirrhosis |
| title_sort |
COVID-19 Vaccination in Liver Cirrhosis |
| author |
Canha, Maria Inês |
| author_facet |
Canha, Maria Inês Cunha, Mário Jorge Silva, Maria Azevedo Costa, Mara Sarmento Saraiva, Rita Ornelas Ruge, André Machado, Mariana Verdelho Félix, Catarina Sousa Morão, Bárbara Figueiredo, Pedro Narra Mendes, Milena Leal, Carina Calinas, Filipe |
| author_role |
author |
| author2 |
Cunha, Mário Jorge Silva, Maria Azevedo Costa, Mara Sarmento Saraiva, Rita Ornelas Ruge, André Machado, Mariana Verdelho Félix, Catarina Sousa Morão, Bárbara Figueiredo, Pedro Narra Mendes, Milena Leal, Carina Calinas, Filipe |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Canha, Maria Inês Cunha, Mário Jorge Silva, Maria Azevedo Costa, Mara Sarmento Saraiva, Rita Ornelas Ruge, André Machado, Mariana Verdelho Félix, Catarina Sousa Morão, Bárbara Figueiredo, Pedro Narra Mendes, Milena Leal, Carina Calinas, Filipe |
| dc.subject.por.fl_str_mv |
Antibodies COVID-19 Infection Liver cirrhosis Vaccine Gastroenterology SDG 3 - Good Health and Well-being |
| topic |
Antibodies COVID-19 Infection Liver cirrhosis Vaccine Gastroenterology SDG 3 - Good Health and Well-being |
| description |
Funding Information: This study was funded by Associação Portuguesa para o Estudo do Fígado, which supported the costs of the antibody titer analysis of every patient at each timepoint. Publisher Copyright: © 2023 The Author(s). Published by S. Karger AG, Basel. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2023-01-01T00:00:00Z 2024-01-24T16:59:47Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/162705 |
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http://hdl.handle.net/10362/162705 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2341-4545 PURE: 81978073 https://doi.org/10.1159/000534740 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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