Induced liver injury after high-dose methylprednisolone in a patient with multiple sclerosis
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.4/2005 |
Resumo: | A 33-year-old woman with multiple sclerosis, medicated with high doses of methylprednisolone, cyclophosphamide and glatiramer acetate, was referred to our department due to acute liver injury. The laboratory investigation was normal except for weakly positive antinuclear antibodies. Cyclophosphamide and glatiramer acetate were suspended, and intravenous immunoglobulin with maintenance of high doses of methylprednisolone was initiated. The patient developed another episode of acute hepatitis so the immunoglobulin was stopped. After that, she had three more episodes of elevation of liver enzymes with no hepatic insufficiency while medicated only with high doses of methylprednisolone. At this time, liver biopsy showed focal centrilobubar hepatocyte necrosis with minimal interface hepatitis. After the high doses of methylprednisolone were suspended, the patient remained asymptomatic, with normal hepatic enzymes. This case emphasises that, although rare, induced liver injury after high doses of methylprednisolone can occur. |
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Induced liver injury after high-dose methylprednisolone in a patient with multiple sclerosisLesão hepática Induzida por Químicos e MedicamentosEsclerose MúltiplaBiopsiaMetilprednisolonaA 33-year-old woman with multiple sclerosis, medicated with high doses of methylprednisolone, cyclophosphamide and glatiramer acetate, was referred to our department due to acute liver injury. The laboratory investigation was normal except for weakly positive antinuclear antibodies. Cyclophosphamide and glatiramer acetate were suspended, and intravenous immunoglobulin with maintenance of high doses of methylprednisolone was initiated. The patient developed another episode of acute hepatitis so the immunoglobulin was stopped. After that, she had three more episodes of elevation of liver enzymes with no hepatic insufficiency while medicated only with high doses of methylprednisolone. At this time, liver biopsy showed focal centrilobubar hepatocyte necrosis with minimal interface hepatitis. After the high doses of methylprednisolone were suspended, the patient remained asymptomatic, with normal hepatic enzymes. This case emphasises that, although rare, induced liver injury after high doses of methylprednisolone can occur.RIHUCOliveira, ATLopes, SCipriano, MASofia, C2016-12-15T14:48:02Z2015-07-212015-07-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.4/2005engBMJ Case Rep. 2015 Jul 21;2015. pii: bcr2015210722.10.1136/bcr-2015-210722info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-11T14:23:18Zoai:rihuc.huc.min-saude.pt:10400.4/2005Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:04:26.834726Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Induced liver injury after high-dose methylprednisolone in a patient with multiple sclerosis |
title |
Induced liver injury after high-dose methylprednisolone in a patient with multiple sclerosis |
spellingShingle |
Induced liver injury after high-dose methylprednisolone in a patient with multiple sclerosis Oliveira, AT Lesão hepática Induzida por Químicos e Medicamentos Esclerose Múltipla Biopsia Metilprednisolona |
title_short |
Induced liver injury after high-dose methylprednisolone in a patient with multiple sclerosis |
title_full |
Induced liver injury after high-dose methylprednisolone in a patient with multiple sclerosis |
title_fullStr |
Induced liver injury after high-dose methylprednisolone in a patient with multiple sclerosis |
title_full_unstemmed |
Induced liver injury after high-dose methylprednisolone in a patient with multiple sclerosis |
title_sort |
Induced liver injury after high-dose methylprednisolone in a patient with multiple sclerosis |
author |
Oliveira, AT |
author_facet |
Oliveira, AT Lopes, S Cipriano, MA Sofia, C |
author_role |
author |
author2 |
Lopes, S Cipriano, MA Sofia, C |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
RIHUC |
dc.contributor.author.fl_str_mv |
Oliveira, AT Lopes, S Cipriano, MA Sofia, C |
dc.subject.por.fl_str_mv |
Lesão hepática Induzida por Químicos e Medicamentos Esclerose Múltipla Biopsia Metilprednisolona |
topic |
Lesão hepática Induzida por Químicos e Medicamentos Esclerose Múltipla Biopsia Metilprednisolona |
description |
A 33-year-old woman with multiple sclerosis, medicated with high doses of methylprednisolone, cyclophosphamide and glatiramer acetate, was referred to our department due to acute liver injury. The laboratory investigation was normal except for weakly positive antinuclear antibodies. Cyclophosphamide and glatiramer acetate were suspended, and intravenous immunoglobulin with maintenance of high doses of methylprednisolone was initiated. The patient developed another episode of acute hepatitis so the immunoglobulin was stopped. After that, she had three more episodes of elevation of liver enzymes with no hepatic insufficiency while medicated only with high doses of methylprednisolone. At this time, liver biopsy showed focal centrilobubar hepatocyte necrosis with minimal interface hepatitis. After the high doses of methylprednisolone were suspended, the patient remained asymptomatic, with normal hepatic enzymes. This case emphasises that, although rare, induced liver injury after high doses of methylprednisolone can occur. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-07-21 2015-07-21T00:00:00Z 2016-12-15T14:48:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.4/2005 |
url |
http://hdl.handle.net/10400.4/2005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
BMJ Case Rep. 2015 Jul 21;2015. pii: bcr2015210722. 10.1136/bcr-2015-210722 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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