Measles antibodies in cord blood in Portugal: Possible consequences for the recommended age of vaccination
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.19/4107 |
Resumo: | The optimum age to give the first dose of measles vaccine must balance the risks of disease and vaccine failure. Both are influenced by the levels of transplacentally acquired maternal antibodies. This study was conducted in the Obstetric service of Portuguese hospital, in 2012-2013. Mothers were recruited after informed consent. Measles IgG was measured in 206 cord sera, using a commercial immunoassay. Geometric mean concentrations (and 95% CI) were 1849mIU/ml (1196-2857) and 790mIU/ml (618-1008) in cord sera of newborns from unvaccinated and vaccinated mothers respectively. Maternal age and vaccination status were both associated with the concentration in cord sera, but maternal age was the major predictor. The likely explanation is the same already mentioned in other studies: as a vaccination program progresses, vaccination coverage increases as measles incidence decreases. That results newborns from younger vaccinated mothers having less measles antibodies while the older mothers are more likely to have been infected with the wild virus. As the proportion of vaccinated mothers increase, developed countries tend to anticipate the recommended age of the first dose to 12 months of age. Models using hypothetical measles antibody decay rates in infancy were explored. Anticipating the first dose of MMR1 in Portugal to the age of 12 months might have not been the best decision but results were not conclusive, and arguments supporting or not the anticipation were discussed. |
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Measles antibodies in cord blood in Portugal: Possible consequences for the recommended age of vaccinationAntibodiesCord bloodMeaslesRecommended ageVaccinationThe optimum age to give the first dose of measles vaccine must balance the risks of disease and vaccine failure. Both are influenced by the levels of transplacentally acquired maternal antibodies. This study was conducted in the Obstetric service of Portuguese hospital, in 2012-2013. Mothers were recruited after informed consent. Measles IgG was measured in 206 cord sera, using a commercial immunoassay. Geometric mean concentrations (and 95% CI) were 1849mIU/ml (1196-2857) and 790mIU/ml (618-1008) in cord sera of newborns from unvaccinated and vaccinated mothers respectively. Maternal age and vaccination status were both associated with the concentration in cord sera, but maternal age was the major predictor. The likely explanation is the same already mentioned in other studies: as a vaccination program progresses, vaccination coverage increases as measles incidence decreases. That results newborns from younger vaccinated mothers having less measles antibodies while the older mothers are more likely to have been infected with the wild virus. As the proportion of vaccinated mothers increase, developed countries tend to anticipate the recommended age of the first dose to 12 months of age. Models using hypothetical measles antibody decay rates in infancy were explored. Anticipating the first dose of MMR1 in Portugal to the age of 12 months might have not been the best decision but results were not conclusive, and arguments supporting or not the anticipation were discussed.ElsevierRepositório Científico do Instituto Politécnico de ViseuGonçalves, GuilhermeNunes, CarlaMesquita, João R.Nascimento, Maria São JoséFrade, João2017-01-26T13:21:10Z2016-05-232016-05-23T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.19/4107engGonçalves, G., Nunes, C., Mesquita, J. R., Nascimento, M. S.-J., & Frade, J. (2016). Measles antibodies in cord blood in Portugal: Possible consequences for the recommended age of vaccination. "Vaccine", 34(24), 2750-2757. doi:10.1016/j.vaccine.2016.04.007.10.1016/j.vaccine.2016.04.007metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-01-16T15:27:01ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Measles antibodies in cord blood in Portugal: Possible consequences for the recommended age of vaccination |
title |
Measles antibodies in cord blood in Portugal: Possible consequences for the recommended age of vaccination |
spellingShingle |
Measles antibodies in cord blood in Portugal: Possible consequences for the recommended age of vaccination Gonçalves, Guilherme Antibodies Cord blood Measles Recommended age Vaccination |
title_short |
Measles antibodies in cord blood in Portugal: Possible consequences for the recommended age of vaccination |
title_full |
Measles antibodies in cord blood in Portugal: Possible consequences for the recommended age of vaccination |
title_fullStr |
Measles antibodies in cord blood in Portugal: Possible consequences for the recommended age of vaccination |
title_full_unstemmed |
Measles antibodies in cord blood in Portugal: Possible consequences for the recommended age of vaccination |
title_sort |
Measles antibodies in cord blood in Portugal: Possible consequences for the recommended age of vaccination |
author |
Gonçalves, Guilherme |
author_facet |
Gonçalves, Guilherme Nunes, Carla Mesquita, João R. Nascimento, Maria São José Frade, João |
author_role |
author |
author2 |
Nunes, Carla Mesquita, João R. Nascimento, Maria São José Frade, João |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico de Viseu |
dc.contributor.author.fl_str_mv |
Gonçalves, Guilherme Nunes, Carla Mesquita, João R. Nascimento, Maria São José Frade, João |
dc.subject.por.fl_str_mv |
Antibodies Cord blood Measles Recommended age Vaccination |
topic |
Antibodies Cord blood Measles Recommended age Vaccination |
description |
The optimum age to give the first dose of measles vaccine must balance the risks of disease and vaccine failure. Both are influenced by the levels of transplacentally acquired maternal antibodies. This study was conducted in the Obstetric service of Portuguese hospital, in 2012-2013. Mothers were recruited after informed consent. Measles IgG was measured in 206 cord sera, using a commercial immunoassay. Geometric mean concentrations (and 95% CI) were 1849mIU/ml (1196-2857) and 790mIU/ml (618-1008) in cord sera of newborns from unvaccinated and vaccinated mothers respectively. Maternal age and vaccination status were both associated with the concentration in cord sera, but maternal age was the major predictor. The likely explanation is the same already mentioned in other studies: as a vaccination program progresses, vaccination coverage increases as measles incidence decreases. That results newborns from younger vaccinated mothers having less measles antibodies while the older mothers are more likely to have been infected with the wild virus. As the proportion of vaccinated mothers increase, developed countries tend to anticipate the recommended age of the first dose to 12 months of age. Models using hypothetical measles antibody decay rates in infancy were explored. Anticipating the first dose of MMR1 in Portugal to the age of 12 months might have not been the best decision but results were not conclusive, and arguments supporting or not the anticipation were discussed. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-05-23 2016-05-23T00:00:00Z 2017-01-26T13:21:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.19/4107 |
url |
http://hdl.handle.net/10400.19/4107 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Gonçalves, G., Nunes, C., Mesquita, J. R., Nascimento, M. S.-J., & Frade, J. (2016). Measles antibodies in cord blood in Portugal: Possible consequences for the recommended age of vaccination. "Vaccine", 34(24), 2750-2757. doi:10.1016/j.vaccine.2016.04.007. 10.1016/j.vaccine.2016.04.007 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
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metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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repository.mail.fl_str_mv |
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1777301965164773376 |